Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Genetic applications of an inverse polymerase chain reaction.

1988 • 1,867 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1986 • 1,033 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

A genetic linkage map of the human genome

1987 • 913 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

A procedure forin vitroamplification of DNA segments that lie outside the boundaries of known sequences

1988 • 814 citations

An electrophoretic karyotype for yeast.

1985 • 787 citations

The bidirectional transfer of DNA and RNA to nitrocellulose or diazobenzyloxymethyl-paper

1980 • 760 citations

[9] Gel electrophoresis of restriction fragments

1979 • 653 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction.

1990 • 454 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome

1983 • 394 citations

Isolation of Single-Copy Human Genes from a Library of Yeast Artificial Chromosome Clones

1989 • 316 citations

Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields

1987 • 309 citations

Identification of the Constant Chromosome Regions Involved in Human Hematologic Malignant Disease

1982 • 309 citations

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

1987 • 236 citations

cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.

1987 • 235 citations

The generation of radiolabeled DNA and RNA probes with polymerase chain reaction

1989 • 211 citations

Novel use of polymerase chain reaction to amplify cellular DNA adjacent to an integrated provirus

1989 • 186 citations

5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA.

1984 • 175 citations

Disease Diagnosis by Recombinant DNA Methods

1987 • 135 citations

Mapping the Drosophila Genome with Yeast Artificial Chromosomes

1989 • 121 citations

Syndromes associated with deletion of the long arm of chromosome 18[del(18q)]

1979 • 115 citations

[35] Strategies for mapping and cloning macroregions of mammalian genomes

1987 • 112 citations

Structure of the Gene for Human Plasminogen Activator Inhibitor-2

1989 • 99 citations

Generation of deletion derivatives by targeted transformation of human-derived yeast artificial chromosomes.

1990 • 93 citations

Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.

1989 • 87 citations

Linkage of theleuS, emtB, andchr genes on chromosome 5 in humans and expression of human genes encoding protein synthetic components in human-Chinese hamster hybrids

1982 • 72 citations

Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene.

1990 • 43 citations

Establishment and characterization of a cell line (Wa-2) derived from an extrarenal rhabdoid tumor.

1990 • 37 citations

Human SSAV-related endogenous retroviral element: LTR-like sequence and chromosomal localization to 18q21

1989 • 30 citations

Regional mapping of the human proto-oncogene c-yes-1 to chromosome 18 at band q21.3.

1985 • 27 citations

Human gastrin-releasing peptide gene maps to chromosome band 18q21

1987 • 26 citations

RFLP identified by the anonymous DNA segment OL VII E10 at 18q21.3 (HGM do. D18S8)

1987 • 20 citations

18q Deletion syndrome in a child with steroid-17,20-lyase deficiency

1986 • 10 citations