Meiotic recombination hot spots and cold spots

The language of covalent histone modifications

2000 • 8,260 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Functional Discovery via a Compendium of Expression Profiles

2000 • 2,581 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

1997 • 1,751 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Regulation of Transcription by a Protein Methyltransferase

1999 • 1,169 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in Recombination

1998 • 1,092 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

An atypical topoisomerase II from archaea with implications for meiotic recombination

1997 • 890 citations

Meiotic chromosomes: it takes two to tango

1997 • 810 citations

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

2000 • 782 citations

The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis

2000 • 772 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

Chromosome Synapsis Defects and Sexually Dimorphic Meiotic Progression in Mice Lacking Spo11

2000 • 684 citations

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

1990 • 683 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

A role for Saccharomyces cerevisiae histone H2A in DNA repair

2000 • 647 citations

Double-strand breaks at an initiation site for meiotic gene conversion

1989 • 533 citations

Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site

1991 • 525 citations

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

1994 • 502 citations

Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae

2000 • 486 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Global histone acetylation and deacetylation in yeast

2000 • 457 citations

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1998 • 453 citations

Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin Structure

1994 • 433 citations

Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure.

1995 • 416 citations

Genomewide studies of histone deacetylase function in yeast

2000 • 415 citations

Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast

1999 • 389 citations

Cohesins Bind to Preferential Sites along Yeast Chromosome III, with Differential Regulation along Arms versus the Centric Region

1999 • 386 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

MEIOTIC RECOMBINATION HOTSPOTS

1995 • 362 citations

MITOTIC CHROMOSOME CONDENSATION

1996 • 319 citations

Clustering of meiotic double-strand breaks on yeast chromosome III

1997 • 317 citations

An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae

1989 • 305 citations

A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element

1996 • 291 citations

Comparison of human genetic and sequence-based physical maps

2001 • 281 citations

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

2000 • 247 citations

Multiple Global Regulators Control HIS4 transcription in Yeast

1987 • 246 citations

Direct Coupling Between Meiotic DNA Replication and Recombination Initiation

2000 • 235 citations

Changes in chromatin structure at recombination initiation sites during yeast meiosis.

1994 • 218 citations

High-Resolution Mapping of Crossovers in Human Sperm Defines a Minisatellite-Associated Recombination Hotspot

1998 • 218 citations

High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot

2000 • 209 citations

Meiotic DNA Breaks Associated with Recombination in S. pombe

2000 • 191 citations

BAS1 Has a Myb Motif and Activates HIS4 Transcription Only in Combination with BAS2

1989 • 176 citations

Factors that affect the location and frequency of meiosis-induced double-strand breaks in Saccharomyces cerevisiae.

1995 • 176 citations

Complex recombination events at the hypermutable minisatellite CEB1 (D2S90).

1994 • 172 citations

The location and structure of double-strand DNA breaks induced during yeast meiosis: evidence for a covalently linked DNA-protein intermediate.

1995 • 169 citations

DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe

1988 • 163 citations

Cloning, Characterization, and Localization of Mouse and Human SPO11

1999 • 157 citations

Transcription factor Mts1/Mts2 (Atf1/Pcr1, Gad7/Pcr1) activates the M 26 meiotic recombination hotspot in Schizosaccharomyces pombe

1997 • 150 citations

Sequence non-specific double-strand breaks and interhomolog interactions prior to double-strand break formation at a meiotic recombination hot spot in yeast.

1995 • 148 citations

RAP1 is required for BAS1/BAS2- and GCN4-dependent transcription of the yeast HIS4 gene.

1991 • 147 citations

The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis.

1986 • 146 citations

Characterization of recombination in the HLA class II region.

1997 • 137 citations

Multiple sites for double-strand breaks in whole meiotic chromosomes of Saccharomyces cerevisiae.

1992 • 135 citations

Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase

2000 • 135 citations

Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.

1993 • 129 citations

The nucleotide mapping of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces cerevisiae.

1995 • 129 citations

GT Repeats Are Associated with Recombination on Human Chromosome 22

2000 • 127 citations

Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae.

1992 • 126 citations

Complete transposition requires four active monomers in the mu transposase tetramer.

1994 • 125 citations

Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe.

1994 • 123 citations

B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis

2001 • 118 citations

Meiosis-Specific Double-Strand DNA Breaks at the HIS4 Recombination Hot Spot in the Yeast Saccharomyces cerevisiae: Control in cis and trans

1995 • 115 citations

Repeat instability at human minisatellites arising from meiotic recombination

1998 • 114 citations

A Mouse Homolog of the Saccharomyces cerevisiae Meiotic Recombination DNA Transesterase Spo11p

1999 • 114 citations

DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.

1991 • 98 citations

Use of a Recombination Reporter Insert To Define Meiotic Recombination Domains on Chromosome III of Saccharomyces cerevisiae

1999 • 95 citations

Allelic diversity at minisatellite MS205 (D16S309): evidence for polarized variability

1993 • 92 citations

The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast.

1997 • 91 citations

The strong ADH1 promoter stimulates mitotic and meiotic recombination at the ADE6 gene of Schizosaccharomyces pombe.

1991 • 83 citations

High resolution localization of recombination hot spots using sperm typing

1994 • 82 citations

Two tightly linked silent cassettes in the mating-type region of Schizosaccharomyces pombe

1984 • 82 citations

Fine mapping of de novo CMT1A and HNPP rearrangements within CMTIA-REPs evidences two distinct sex-dependent mechanisms and candidate sequences involved in recombination

1998 • 81 citations

A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast

1992 • 78 citations

Relationship between Nuclease-Hypersensitive Sites and Meiotic Recombination Hot Spot Activity at the HIS4 Locus of Saccharomyces cerevisiae

1996 • 78 citations

A yeast acts in (Cis) to inhibit meiotic gene conversion of adjacent sequences

1988 • 73 citations

Control of Meiotic Recombination and Gene Expression in Yeast by a Simple Repetitive DNA Sequence That Excludes Nucleosomes

1999 • 73 citations

Polarity of meiotic gene conversion in fungi: Contrasting views

1994 • 72 citations

DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot.

1991 • 72 citations

An Isochore Transition in the NF1 Gene Region Coincides with a Switch in the Extent of Linkage Disequilibrium

2000 • 72 citations

The control in cis of the position and the amount of the ARG4 meiotic double-strand break of Saccharomyces cerevisiae.

1993 • 71 citations

Communication between homologous chromosomes: genetic alterations at a nuclease‐hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans

1996 • 70 citations

His and hers recombinational hotspots

1991 • 68 citations

Competition Between Adjacent Meiotic Recombination Hotspots in the Yeast Saccharomyces cerevisiae

1997 • 64 citations

(CA/GT)_n microsatellites affect homologous recombination during yeast meiosis

2000 • 62 citations

The [(G/C)3NN]n motif: a common DNA repeat that excludes nucleosomes.

1996 • 55 citations

Sensing of DNA non‐homology lowers the initiation of meiotic recomination in yeast

1996 • 53 citations

2 Meiotic Recombination Hotspots: Shaping the Genome and Insights into Hypervariable Minisatellite DNA Change

1997 • 50 citations

Hot spots of recombination in fission yeast: inactivation of the M26 hot spot by deletion of the ade6 promoter and the novel hotspot ura4-aim.

1995 • 47 citations

Patterns of meiotic double-strand breakage on native and artificial yeast chromosomes

1996 • 45 citations

Fine-Structure Mapping of Meiosis-Specific Double-Strand DNA Breaks at a Recombination Hotspot Associated With an Insertion of Telomeric Sequences Upstream of the HIS4 Locus in Yeast

1996 • 44 citations

Maximal Stimulation of Meiotic Recombination by a Yeast Transcription Factor Requires the Transcription Activation Domain and a DNA-Binding Domain

1999 • 40 citations

Identification and characterization of an SPO11 homolog in the mouse

2000 • 32 citations

Active and inactive transplacement of the M26 recombination hotspot in Schizosaccharomyces pombe.

1995 • 31 citations

Meiotic double-strand breaks in Schizosaccharomyces pombe

2000 • 28 citations

Competitive inactivation of a double-strand DNA break site involves parallel suppression of meiosis-induced changes in chromatin configuration

1999 • 27 citations

Inference of recombinational hotspots using gametic disequilibrium values

1988 • 26 citations

DNA motif associated with meiotic double‐strand break regions in Saccharomyces cerevisiae

2000 • 22 citations

Morphology of a human-derived YAC in yeast meiosis

1995 • 21 citations