Pyruvate Metabolism inSaccharomyces cerevisiae

New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae

1994 • 2,554 citations

Yeasts: Characteristics and Identification

1983 • 1,989 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast

1991 • 1,369 citations

Foreign gene expression in yeast: a review

1992 • 1,039 citations

A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

1987 • 887 citations

Multienzyme complexes

1974 • 655 citations

Enzymic analysis of the crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae

1989 • 601 citations

Redox balances in the metabolism of sugars by yeasts

1986 • 584 citations

Yeasts: Characteristics and identification

1984 • 566 citations

Physiology of Saccharomyces Cerevisiae in Anaerobic Glucose-Limited Chemostat Culturesx

1990 • 471 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

1988 • 449 citations

A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH

1992 • 448 citations

Signal transduction in yeast

1994 • 385 citations

Carbon catabolite repression in yeast

1992 • 365 citations

NADH-linked aldose reductase: the key to anaerobic alcoholic fermentation of xylose by yeasts

1984 • 343 citations

The 2-oxo acid dehydrogenase complexes: recent advances

1989 • 321 citations

ALTERNATIVE PATHWAYS OF CARBOHYDRATE UTILIZATION IN PSEUDOMONADS

1984 • 316 citations

From DNA sequence to biological function

1996 • 309 citations

Overproduction of glycolytic enzymes in yeast

1989 • 295 citations

The role of redox balances in the anaerobic fermentation of xylose by yeasts

1983 • 268 citations

Oxygen requirements of yeasts

1990 • 264 citations

A Kinetic Study of Glycolytic Enzyme Synthesis in Yeast

1971 • 263 citations

Energy-Yielding Metabolism

1968 • 257 citations

Energetics of Saccharomyces Cerevisiae in Anaerobic Glucose-Limited Chemostat Cultures

1990 • 252 citations

Porin from Bacterial and Mitochondrial Outer Membrane

1985 • 246 citations

METABOLISM OF METHYLGLYOXAL IN MICROORGANISMS

1984 • 242 citations

An Enzymic Analysis of NADPH Production and Consumption in Candida utilis

1983 • 241 citations

The Two Acetyl-coenzyme A Synthetases of Saccharomyces cerevisiae Differ with Respect to Kinetic Properties and Transcriptional Regulation

1996 • 238 citations

A theoretical evaluation of growth yields of yeasts

1991 • 235 citations

Phosphorus-31 nuclear magnetic resonance studies of the effect of oxygen upon glycolysis in yeast

1981 • 214 citations

Kinetics of growth and sugar consumption in yeasts

1993 • 202 citations

Pyruvate Decarboxylase: An Indispensable Enzyme for Growth of Saccharomyces cerevisiae on Glucose

1996 • 197 citations

Effect of Oxygenation on Xylose Fermentation by Pichia stipitis

1990 • 195 citations

The Role Of Limited Respiration In The Incomplete Oxidation Of Glucose By Saccharomyces Cerevisiae

1983 • 193 citations

A Theoretical Analysis of NADPH Production and Consumption in Yeasts

1983 • 187 citations

Metabolic control theory: its role in microbiology and biotechnology

1986 • 186 citations

Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae

1991 • 179 citations

REACTION PRODUCTS OF YEAST FERMENTATIONS.

1977 • 177 citations

CARBOXYLASE

1941 • 167 citations

Physiology of yeasts in relation to biomass yields

1991 • 166 citations

Transient-State Analysis of Metabolic Fluxes in Crabtree-Positive and Crabtree-Negative Yeasts

1990 • 162 citations

Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5

1990 • 162 citations

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

1992 • 160 citations

An Expanded Concept for the Glucose Effect in the Yeast Saccharomyces uvarum: Involvement of Short- and Long-term Regulation

1983 • 155 citations

Physiological and technological aspects of large-scale heterologous-protein production with yeasts

1995 • 150 citations

Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol

1995 • 146 citations

Misconceptions about the energy metabolism of Saccharomyces cerevisiae

1986 • 134 citations

An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability.

1995 • 121 citations

The Mechanism of Substrate Activation of Pyruvate Decarboxylase: A First Approach

1978 • 119 citations

Allosteric properties of yeast pyruvate decarboxylase

1970 • 119 citations

ACS2, a Saccharomyces Cerevisiae Gene Encoding Acetyl-Coenzyme A Synthetase, Essential for Growth on Glucose

1995 • 118 citations

Development of Metabolically Engineered Saccharomyces cerevisiae Cells for the Production of Lactic Acid

1995 • 115 citations

Properties and Function of Yeast Pyruvate Carboxylase

1965 • 114 citations

Glucose repression: a complex regulatory system in yeast.

1986 • 113 citations

Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis

1982 • 112 citations

The synthesis of yeast pyruvate decarboxylase is regulated by large variations in the messenger RNA level

1983 • 110 citations

Effects of oxygen limitation on sugar metabolism in yeasts: a continuous-culture study of the Kluyver effect

1994 • 105 citations

ACS2, a Saccharomyces Cerevisiae Gene Encoding Acetyl-Coenzyme A Synthetase, Essential for Growth on Glucose

1995 • 105 citations

Kinetics of microbial growth with mixtures of carbon sources

1993 • 105 citations

Global Regulation of Mitochondrial Biogenesis in Saccharomyces cerevisiae

1993 • 98 citations

Effects of growth conditions on mitochondrial morphology inSaccharomyces cerevisiae

1995 • 97 citations

DNA sequences in chromosomes 11 and VII code for pyruvate carboxylase isoenzymes in Saccharomyces cerevisiae: analysis of pyruvate carboxylase-deficient strains

1991 • 97 citations

AnalysIs of the primary structure and promoter function of a pyruvate decarbozylase gene (PDCI) fromSaceharomyces cerevisiae

1986 • 95 citations

A yeast mutant lacking mitochondrial porin is respiratory-deficient, but can recover respiration with simultaneous accumulation of an 86-kd extramitochondrial protein.

1987 • 92 citations

Localization and kinetics of pyruvate-metabolizing enzymes in relation to aerobic alcoholic fermentation in Saccharomyces cerevisiae CBS 8066 and Candida utilis CBS 621

1989 • 91 citations

Alcoholic fermentation by ‘non‐fermentative’ yeasts

1986 • 89 citations

Energetic aspects of glucose metabolism in a pyruvate-dehydrogenase-negative mutant of Saccharomyces cerevisiae

1994 • 87 citations

PDA1mRNA: a standard for quantitation of mRNA inSaccharomyces cerevisiaesuperior toACT1mRNA

1995 • 86 citations

Regulation of Carbohydrate Metabolism by Enzyme Competition

1961 • 85 citations

Cloning and disruption of a gene required for growth on acetate but not on ethanol: The acetyl‐coenzyme a synthetase gene of Saccharmoyces cerevisiae

1992 • 83 citations

The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase.

1993 • 83 citations

Pyruvate Dehydrogenase Complex from Baker's Yeast. 1. Purification and Some Kinetic and Regulatory Properites

1981 • 83 citations

Analysis of transcription and translation of glycolytic enzymes in glucose-limited continuous cultures of Saccharomyces cerevisiae

1992 • 81 citations

Regulation of Pyruvate Carboxylase Isozyme (PYC1, PYC2) Gene Expression in Saccharomyces cerevisiae during Fermentative and Nonfermentative Growth

1994 • 80 citations

Stimulation of Fermentation in Yeasts by Acetoin and Oxygen

1966 • 78 citations

Different signals control the activation of glycolysis in the yeast Saccharomyces cerevisiae

1993 • 77 citations

The Utilization of Disaccharides and Some Other Sugars RY Yeasts

1981 • 77 citations

The Requirement of Oxygen for the Utilization of Maltose, Cellobiose and D-Galactose by Certain Anaerobically Fermenting Yeasts (Kluyver Effect)

1978 • 76 citations

pdc1(0) mutants of Saccharomyces cerevisiae give evidence for an additional structural PDC gene: cloning of PDC5, a gene homologous to PDC1

1990 • 73 citations

Cloning and nucleotide sequence of the gene for dihydrolipoamide acetyltransferase from Saccharomyces cerevisiae.

1988 • 73 citations

TheILVSgene ofSaccharomyces cerevisiaeis highly expressed

1986 • 72 citations

Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevlsiae

1993 • 71 citations

Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex

1991 • 71 citations

Yeast pyruvate carboxylase: Identification of two genes encoding isoenzymes

1991 • 70 citations

3 Pyruvate Dehydrogenase

1987 • 69 citations

Katabolit-Repression und der Sprossungszyklus von Saccharomyces cerevisiae

1969 • 68 citations

Mitochondrial acetaldehyde dehydrogenase from Saccharomyces cerevisiae

1974 • 68 citations

A deletion of the PDC1 gene for pyruvate decarboxylase of yeast causes a different phenotype than previously isolated point mutations

1989 • 67 citations

Subcellular Localization of the Leucine Biosynthetic Enzymes in Yeast

1973 • 65 citations

Cloning and nucleotide sequence of the gene for protein X from Saccharomyces cerevisiae.

1989 • 62 citations

The catabolism of branched-chain amino acids occurs via 2-oxoacid dehydrogenase in Saccharomyces cerevisiae

1992 • 61 citations

PDC6, a weakly expressed pyruvate decarboxylase gene from yeast, is activated when fused spontaneously under the control of the PDC1 promoter

1991 • 59 citations

Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACSI from saccharomyces cerevisiae

1995 • 59 citations

The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae

1994 • 56 citations

Production of extracellular inulinase in high-cell-density fed-batch cultures of Kluyveromyces marxianus

1994 • 55 citations

Structure and regulation of the isocitrate lyase gene ICL1 from the yeast Saccharomyces cerevisiae

1993 • 55 citations

Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae.

1995 • 55 citations

Structural properties of pyruvate carboxylases from chicken liver and other sources.

1975 • 53 citations

Induction of pyruvate decarboxylase in glycolysis mutants of Saccharomyces cerevisiae correlates with the concentrations of three-carbon glycolytic metabolites

1993 • 53 citations

Catabolite inactivation of isocitrate lyase from Saccharomyces cerevisiae

1987 • 52 citations

Metabolic and energetic aspects of the growth of Klebsiella aerogenes NCTC 418 on glucose in anaerobic chemostat culture

1983 • 52 citations

Characterization of Saccharomyces cerevisiae mutants lacking the E1α subunit of the pyruvate dehydrogenase complex

1992 • 51 citations

A mutation affecting lipoamide dehydrogenase, pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase activities in Saccharomyces cerevisiae

1986 • 50 citations

Verhalten der Glycerinsäure und der Weinsäure gegen wasserentziehende Substanzen

1881 • 50 citations

Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakers' yeast

1986 • 50 citations

The Nucleotide Sequence of the LPD1 Gene Encoding Lipoamide Dehydrogenase in Saccharomyces cerevisiae: Comparison between Eukaryotic and Prokaryotic Sequences for Related Enzymes and Identification of Potential Upstream Control Sites

1988 • 49 citations

Carnitine Acetyltransferase: Candidate for the Transfer of Acetyl Groups Through the Mitochondrial Membrane of Yeast

1977 • 49 citations

Location of three key enzymes of gluconeogenesis in baker's yeast

1977 • 47 citations

Pyruvate — Oxaloacetate exchange reaction in baker's yeast

1964 • 44 citations

Pyruvate decarboxylase III

1975 • 43 citations

Electron microscopic localization of pyruvate carboxylase in rat liver and Saccharomyces cerevisiae by immunogold procedures

1991 • 42 citations

Pyruvate Dehydrogenase Complex from Baker's Yeast. 2. Molecular Structure, Dissociation, and Implications for the Origin of Mitochondria

1981 • 40 citations

Positive regulation of the LPD1 gene of Saccharomyces cerevisine by the HAP2/HAP3/HAP4 activation system

1992 • 40 citations

Molecular cloning of the gene for the E1α subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae

1990 • 39 citations

The movement of monocarboxylic acids across phospholipid membranes: evidence for an exchange diffusion between pyruvate and other monocarboxylate ions

1974 • 38 citations

Isolation and characterization of carnitine acetyltransferase from S. cerevisiae

1991 • 38 citations

Fine control of the conversion of pyruvate (phosphoenolpyruvate) to oxaloacetate in various species

1978 • 38 citations

Resolution of brewers' yeast pyruvate decarboxylase into two isozymes.

1986 • 37 citations

Purification and functional characterisation of the pyruvate (monocar☐ylate) carrier from baker's yeast mitochondria (Saccharomyces cerevisiae)

1991 • 37 citations

Nucleotide and deduced amino acid sequence of the alpha subunit of yeast pyruvate dehydrogenase

1989 • 37 citations

Pyruvate carboxylase from Saccharomyces cerevisiae. Quaternary structure, effects of allosteric ligands and binding of avidin

1986 • 36 citations

Cloning and Characterization of the Gene Encoding Lipoamide Dehydrogenase in Saccharomyces Cerevisiae

1987 • 35 citations

Functional analysis of the domains of dihydrolipoamide acetyltransferase from Saccharomyces cerevisiae

1991 • 33 citations

Inhibition of yeast pyruvate carboxylase by L-aspartate and oxaloacetate

1966 • 31 citations

Characterization of PDH beta 1, the structural gene for the pyruvate dehydrogenase beta subunit from Saccharomyces cerevisiae.

1993 • 30 citations

A mutation affecting carbon catabolite repression suppresses growth defects in pyruvate carboxylase mutants from Saccharomyces cerevisiae

1995 • 30 citations

Pyruvate carboxylase from a thermophilic Bacillus. Studies on the specificity of activation by acyl derivatives of coenzyme A and on the properties of catalysis in the absence of activator

1978 • 28 citations

Carbon Dioxide Fixation by Baker's Yeast in a Variety of Growth Conditions

1980 • 27 citations

Transport of pyruvate and lactate in yeast mitochondria

1977 • 26 citations

Regulation of the PDA1 gene encoding the E1α subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae

1993 • 26 citations

Inactivation of yeast alpha-isopropylmalate synthase by CoA. Antagonism between CoA and adenylates and the mechanism of CoA inactivation.

1981 • 25 citations

Response of yeast pyruvate carboxylase to the adenylate energy charge and other regulatory parameters

1972 • 23 citations

On the origin of mitochondria: a reexamination of the molecular structure and kinetic properties of pyruvate dehydrogenase complex from brewer's yeast

1982 • 22 citations

Yeast pyruvate carboxylase: Gene isolation

1987 • 22 citations

Pyruvate holocarboxylase formation from the apoenzyme and d-biotin in Saccharomyces cerevisiae

1971 • 21 citations

The pyruvate dehydrogenase complex of Saccharomyces cerevisiae is regulated by phosphorylation

1995 • 21 citations

Enzymatic formation of α-acetolactate from α-hydroxyethyl-2-thiamine pyrophosphate (“active acetaldehyde”) and pyruvate

1961 • 20 citations

Evidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase

1991 • 20 citations

Transient responses of Candida utilis to oxygen limitation: Regulation of the Kluyver effect for maltose

1995 • 19 citations

OXALOACETATE, CITRAMALATE AND GLUTAMATE FORMATION FROM PYRUVATE IN BAKER'S YEAST.

1964 • 18 citations

A comparative radiorespirometric study of glucose metabolism in yeasts

1986 • 17 citations

Effects of adenosine phosphates and nicotinamide nucleotides on pyruvate carboxylase from baker's yeast

1969 • 16 citations

On the activity of carbon dioxide fixation in growing yeasts

1973 • 15 citations

Activation of yeast pyruvate carboxylase: interactions between acyl coenzyme A compounds, aspartate, and substrates of the reaction

1983 • 15 citations

Identification, cloning and characterisation of a new gene required for full pyruvate decarboxylase activity in Saccharomyces cerevisiae

1989 • 15 citations

Protein phosphorylation by inorganic pyrophosphate in yeast mitochondria

1991 • 13 citations

Quaternary structure of yeast pyruvate carboxylase: biochemical and electron microscope studies

1979 • 12 citations

Induction of pyruvate decarboxylase in Candida utilis

1983 • 11 citations

Effect of aeration on the activity of gluconeogenetic enzymes in Saccharomyces cerevisiae growing under glucose limitation

1975 • 10 citations

Influence of oxygen limitation on glucose metabolism in Hanseniaspora uvarum K5 grown in chemostat

1995 • 10 citations

Petite-negative mutants of Saccharomyces cerevisiae

1981 • 8 citations

Promoter analysis of the PDA1 gene encoding the E1α subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae

1994 • 8 citations