Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.

Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate

1971 • 1,736 citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

Crystalline Dihydropteroylglutamic Acid

1960 • 461 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Topics in Molecular Pharmacology

1984 • 141 citations

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis

1976 • 112 citations

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase

1981 • 64 citations

Regulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vivo and in vitro synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells.

1982 • 59 citations

A kinetic study of thymidylate synthase from Lactobacillus casei.

1978 • 54 citations

Effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei

1975 • 54 citations

Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver

1984 • 51 citations

The primary structure of Lactobacillus casei thymidylate synthetase. I. The isolation of cyanogen bromide peptides 1 through 5 and the complete amino acid sequence of CNBr 1, 2, 3, and 5.

1979 • 46 citations

Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation.

1977 • 45 citations

The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4.

1979 • 41 citations

[Site of necessary synthesis of saccharose in sugar beet].

1954 • 37 citations

Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate.

1979 • 33 citations

Fluorine-19 nuclear magnetic resonance characterization of ternary complexes of folate derivatives, 5-fluorodeoxyuridylate and Lactobacillus casei thymidylate synthetase

1981 • 33 citations

Determination of three different pools of reduced one-carbon-substituted folates. II. Quantitation and chain-length determination of the pteroylpolyglutamates of rat liver

1981 • 29 citations

Fluorine-19 nuclear magnetic resonance investigation of the noncovalent and covalent binary complexes of 5-fluorodeoxyuridylate and Lactobacillus casei thymidylate synthetase

1980 • 29 citations

Trapping and partial characterization of an adduct postulated to be the covalent catalytic ternary complex of thymidylate synthase

1986 • 27 citations

Isolation of the covalent binary complex of 5-fluorodeoxyuridylate and thymidylate synthetase by trichloroacetic acid precipitation

1984 • 26 citations

A nitrocellulose-filter assay for the binary complex of 5-fluorodeoxyuridylate and Lactobacillus casei thymidylate synthetase

1985 • 8 citations