The role of early growth response gene 1 (egr-1) in regulation of the immune response

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

1978 • 1,624 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Molecular physiology of granulocyte-macrophage colony-stimulating factor

1991 • 598 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) and Related Transcription-Activating Deoxyribonucleic Acid-Binding Proteins*

1993 • 476 citations

Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

1994 • 419 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Identification of a phorbol ester-repressible v-src-inducible gene.

1989 • 322 citations

A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens.

1987 • 292 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes.

1991 • 216 citations

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

1994 • 203 citations

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

1992 • 200 citations

Transcriptional regulation by CREB and its relatives

1993 • 197 citations

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.

1990 • 179 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene

1988 • 158 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Complexity of the primary genetic response to mitogenic activation of human T cells.

1989 • 149 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

1991 • 132 citations

Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter

1994 • 126 citations

Role of primary response genes in generating cellular responses to growth factors

1992 • 124 citations

The Zinc Finger Transcription Factor Egr-1 Potentiates Macrophage Differentiation of Hematopoietic Cells

1995 • 120 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line

1991 • 105 citations

Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene.

1994 • 100 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter.

1994 • 96 citations

The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle.

1994 • 95 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation.

1990 • 82 citations

Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells.

1989 • 81 citations

B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.

1993 • 81 citations

A Set of Human Putative Lymphocyte G₀/G₁Switch Genes Includes Genes Homologous to Rodent Cytokine and Zinc Finger Protein-Encoding Genes

1990 • 77 citations

Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase.

1991 • 75 citations

Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway.

1993 • 73 citations

A Ternary Complex Factor-Dependent Mechanism Mediates Induction of egr-1 through Selective Serum Response Elements following Antigen Receptor Cross-Linking in B Lymphocytes

1995 • 72 citations

Identification of Genes Induced during Apoptosis in T Lymphocytes

1994 • 71 citations

Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages.

1992 • 67 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation

1992 • 56 citations

Determinants of the brain‐specific expression of the rat aldolase C gene: ex vivo and in vivo analysis

1993 • 56 citations

Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes.

1995 • 54 citations

AP-1 and Krox-24 transcription factors activate the neurofilament light gene promoter in P19 embryonal carcinoma cells.

1994 • 50 citations

Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.

1993 • 50 citations

The Zif268 cellular transcription factor activates expression of the Epstein-Barr virus immediate-early BRLF1 promoter

1995 • 47 citations

Characterization of the Human Inosine-5′-monophosphate Dehydrogenase Type II Gene

1995 • 42 citations

Granulocyte-macrophage colony-stimulating factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages.

1991 • 34 citations

Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-/- mice

1994 • 33 citations

Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid.

1993 • 31 citations

Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter

1994 • 29 citations

The Egr Family of Nuclear Signal Transducers

1991 • 26 citations

Granulocyte‐macrophage colony‐stimulating factor stimulates the metastatic properties of lewis lung carcinoma cells through a protein kinase a signal‐transduction pathway

1993 • 25 citations

Growth of LLC-PK1 renal cells is mediated by EGR-1 up-regulation of G protein alpha i-2 protooncogene transcription.

1994 • 23 citations

Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.

1994 • 19 citations

Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(.beta.-D-arabinofuranosyl)cytosine

1993 • 19 citations

Transient transfection of murine B lymphocyte blasts as a method for examining gene regulation in primary B cells

1995 • 16 citations

The molecular and cellular biology of interleukin-3.

1989 • 13 citations