Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

1995 • 985 citations

Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

1997 • 662 citations

Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years

1997 • 569 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

1996 • 474 citations

Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat

1990 • 454 citations

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

1981 • 447 citations

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

1996 • 427 citations

Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease

1991 • 402 citations

Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

1993 • 315 citations

Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

1992 • 313 citations

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

1995 • 312 citations

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1996 • 281 citations

PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs

1993 • 228 citations

Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

1995 • 151 citations

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production

1982 • 150 citations

Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513→ Arg and Ile523→ Val Mutation

1997 • 125 citations

Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: Anti-inflammatory without gastropathy?

1993 • 74 citations

Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors

1995 • 62 citations

The potentiation of taurocholate‐induced rat gastric erosions following parenteral administration of cyclo‐oxygenase inhibitors

1983 • 60 citations

Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats

1996 • 49 citations