Stimulation of In Vitro Rat Muscle Protein Synthesis by Leucine Decreases with Age

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Orally Administered Leucine Stimulates Protein Synthesis in Skeletal Muscle of Postabsorptive Rats in Association with Increased eIF4F Formation

2000 • 471 citations

Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction

1999 • 417 citations

Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6

1999 • 356 citations

Splanchnic and whole-body leucine kinetics in young and elderly men

1997 • 347 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 331 citations

Protein pulse feeding improves protein retention in elderly women

1999 • 280 citations

Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids

1988 • 279 citations

Skeletal muscle atrophy in old rats: Differential changes in the three fiber types

1991 • 238 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Amino Acid Limitation Induces Expression of CHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1997 • 203 citations

The adult decline in lean body mass.

1976 • 177 citations

Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes

2000 • 164 citations

Effect of dietary protein on translation initiation in rat skeletal muscle and liver

1998 • 156 citations

Altered response of protein synthesis to nutritional state and endurance training in old rats

1995 • 145 citations

Effects of branched‐chain amino acids on protein turnover

1989 • 132 citations

Amino acids stimulate phosphorylation of p70 ^S6k and organization of rat adipocytes into multicellular clusters

1998 • 130 citations

Phosphatidylinositol 3-kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I.

1996 • 119 citations

Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats

1994 • 111 citations

Structural requirement of leucine for activation of p70 S6 kinase

1999 • 98 citations

Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression

1998 • 93 citations

Postprandial stimulation of muscle protein synthesis is independent of changes in insulin

1997 • 86 citations

Effect of a Test Meal, without and with Protein, on Muscle and Plasma Free Amino Acids

1990 • 80 citations

Effect of amino acids alone or with insulin on muscle and liver protein synthesis in adult and old rats

1993 • 71 citations

Differential Responsiveness of Protein Synthesis and Degradation to Amino Acid Availability in Humans

1996 • 67 citations

Amino acid metabolism in muscle and in the whole body of man before and after ingestion of a single mixed meal

1989 • 64 citations

Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion

1993 • 42 citations

The influence of chronic dietary intervention on protein turnover and growth of the diaphragm and extensor digitorum longus muscles of the rat

1987 • 39 citations

Diazoxide-induced insulin deficiency greatly reduced muscle protein synthesis in rats: involvement of eIF4E

1999 • 33 citations

Transfers of N metabolites across the ovine liver in response to short-term infusions of an amino acid mixture into the mesenteric vein

1998 • 19 citations