Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

2004 • 654 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells

2001 • 610 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

2004 • 482 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD

2004 • 420 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

2004 • 360 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development

1998 • 264 citations

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

2002 • 194 citations

Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells

2006 • 153 citations

Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells

2005 • 87 citations

Murine CD4+CD25+ Regulatory T Cells Fail to Undergo Chromatin Remodeling Across the Proximal Promoter Region of the IL-2 Gene

2004 • 75 citations

Dysfunctional cytokine production by host-reactive T-cell clones isolated from a chimeric severe combined immunodeficiency patient transplanted with haploidentical bone marrow

1995 • 22 citations

Human CD4+ regulatory T cells and activation-induced tolerance

2005 • 16 citations