Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2)

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties11Edited by B. Honig

2001 • 1,203 citations

Hidden Markov models for detecting remote protein homologies.

1998 • 1,122 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

2001 • 460 citations

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

2001 • 438 citations

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model

1997 • 433 citations

Conjugation position of quercetin glucuronides and effect on biological activity

2000 • 365 citations

Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability

2003 • 349 citations

Plasma metabolites of quercetin and their antioxidant properties

1998 • 333 citations

Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions

2000 • 313 citations

ABC of oral bioavailability: transporters as gatekeepers in the gut

2003 • 311 citations

Intestinal Transport of Quercetin Glycosides in Rats Involves Both Deglycosylation and Interaction with the Hexose Transport Pathway

2000 • 308 citations

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)

2003 • 301 citations

Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism

2003 • 266 citations

RETRACTED: Structure of MsbA from Vibrio cholera: A Multidrug Resistance ABC Transporter Homolog in a Closed Conformation

2003 • 262 citations

Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition

2002 • 240 citations

ABSORPTION/METABOLISM OF SULFORAPHANE AND QUERCETIN, AND REGULATION OF PHASE II ENZYMES, IN HUMAN JEJUNUM IN VIVO

2003 • 217 citations

Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen

1999 • 209 citations

Efflux of dietary flavonoid quercetin 4'-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2.

2000 • 206 citations

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2

2004 • 174 citations

Flavonoid glucuronides are substrates for human liver β‐glucuronidase

2001 • 166 citations

Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic Anions

2003 • 152 citations

Properties of Quercetin Conjugates: Modulation of LDL Oxidation and Binding to Human Serum Albumin

2004 • 134 citations

Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides

2005 • 121 citations

Interplay between MRP Inhibition and Metabolism of MRP Inhibitors: The Case of Curcumin

2003 • 118 citations

Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake.

1999 • 117 citations

Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids

1997 • 115 citations

Quercetin Metabolites Downregulate Cyclooxygenase-2 Transcription in Human Lymphocytes Ex Vivo but Not In Vivo

2004 • 104 citations

Convenient syntheses of metabolically important quercetin glucuronides and sulfates

2006 • 95 citations

Fold prediction by a hierarchy of sequence, threading, and modeling methods

1998 • 93 citations

Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells

2000 • 86 citations

The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds.

2002 • 84 citations

Identification of the Multidrug‐Resistance Protein (MRP) as the Glutathione‐S‐Conjugate Export Pump of Erythrocytes

1996 • 80 citations

Molecular Modeling Correctly Predicts the Functional Importance of Phe594 in Transmembrane Helix 11 of the Multidrug Resistance Protein, MRP1 (ABCC1)

2003 • 68 citations

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins

2003 • 65 citations

Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.

2001 • 62 citations

Glucuronidation of the Green Tea Catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by Rat Hepatic and Intestinal Microsomes

2004 • 26 citations

Modulation of the heat-induced activation of mitogen-activated protein (MAP) kinase by quercetin

1998 • 21 citations

Cited By (0)

Loading...