Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic Anions

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

1999 • 663 citations

The multidrug resistance protein family

1999 • 654 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions

2000 • 313 citations

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

2002 • 305 citations

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver

2001 • 284 citations

Tissue Distribution and Induction of Human Multidrug Resistant Protein 3

2002 • 262 citations

Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)

2001 • 255 citations

Functional expression of the canalicular bile salt export pump of human liver

2002 • 253 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

The role of multidrug transporters in drug availability, metabolism and toxicity

2003 • 211 citations

Membrane Topology and Glycosylation of the Human Multidrug Resistance-associated Protein

1996 • 209 citations

Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)

2003 • 195 citations

Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma

2001 • 188 citations

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.

1999 • 178 citations

MRP subfamily transporters and resistance to anticancer agents.

2001 • 170 citations

Function, evolution and structure of multidrug resistance protein (MRP)

1997 • 168 citations

Pharmacology, 3rd edn

1982 • 156 citations

Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein

1996 • 154 citations

Mutation of Trp1254 in the Multispecific Organic Anion Transporter, Multidrug Resistance Protein 2 (MRP2) (ABCC2), Alters Substrate Specificity and Results in Loss of Methotrexate Transport Activity

2001 • 130 citations

Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells.

1998 • 102 citations

Biochemical and molecular aspects of genetic disorders of bilirubin metabolism

1998 • 94 citations

Cholestatic Properties and Hepatic Transport of Steroid Glucuronides

1997 • 53 citations

Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate

2001 • 47 citations

Biliary excretion of estradiol-17 beta-glucuronide in the rat

1996 • 41 citations

Hepatotoxic effects of estradiol-17 beta-D-glucuronide in the rat and monkey.

1983 • 29 citations

Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.

1986 • 22 citations

The effect of pregnancy and treatment with 17 beta-estradiol on the transport of organic anions into isolated rat hepatocytes.

1984 • 16 citations

Gene therapy for prostate cancer

1997 • 14 citations

A biliary milestone: Functional expression of the human bile salt export pump

2002 • 9 citations

Consent and Equipoise, the Crucial Ethical Issues in Randomised Clinical Trials

2003 • 2 citations