A functional classification scheme for beta-lactamases and its correlation with molecular structure

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

The structure of β-lactamases

1980 • 1,705 citations

Extended Broad-Spectrum -Lactamases Conferring Transferable Resistance to Newer -Lactam Agents in Enterobacteriaceae: Hospital Prevalence and Susceptibility Patterns

1988 • 1,540 citations

Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens

1983 • 926 citations

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

1978 • 791 citations

More extended-spectrum beta-lactamases

1991 • 740 citations

The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role

1973 • 719 citations

SERINE β-LACTAMASES AND PENICILLIN-BINDING PROTEINS

1991 • 610 citations

Transferable imipenem resistance in Pseudomonas aeruginosa

1991 • 602 citations

Penicillinase Synthesis Controlled By Infectious R Factors In Enterobacteriaceae

1965 • 555 citations

The β-lactamases of Gram-negative bacteria and their rôle in resistance to β-lactam antibiotics

1976 • 539 citations

Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance

1994 • 436 citations

Evolution of plasmid-coded resistance to broad-spectrum cephalosporins

1985 • 421 citations

Outbreak of ceftazidime resistance caused by extended-spectrum beta-lactamases at a Massachusetts chronic-care facility

1990 • 394 citations

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

1981 • 384 citations

Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel β-lactamase

1987 • 366 citations

Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae

1990 • 310 citations

Characterization of beta-lactamases

1989 • 302 citations

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

1993 • 273 citations

Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia

1982 • 234 citations

Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.

1987 • 228 citations

Plasmid-mediated β-lactamases of Gram-negative bacteria: properties and distribution

1979 • 227 citations

Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'

1989 • 224 citations

.beta.-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin

1980 • 222 citations

Properties of plasmids responsible for production of extended-spectrum beta-lactamases

1991 • 203 citations

Characterization of a novel extended-spectrum beta-lactamase from Pseudomonas aeruginosa

1993 • 202 citations

Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients

1992 • 197 citations

Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae

1989 • 197 citations

Cephalosporinase and penicillinase activities of a β-lactamase from Pseudomonas pyocyanea

1965 • 195 citations

An overview of the kinetic parameters of class B β-lactamases

1993 • 192 citations

A new plasmidic cefotaximase from patients infected withSalmonella typhimurium

1992 • 188 citations

The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases

1991 • 183 citations

PURIFICATION AND PROPERTIES OF PENICILLINASES FROM TWO STRAINS OF BACILLUS LICHENIFORMIS: A CHEMICAL, PHYSICOCHEMICAL AND PHYSIOLOGICAL COMPARISON

1965 • 178 citations

OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa

1993 • 176 citations

Classification of beta-lactamases: groups 2c, 2d, 2e, 3, and 4

1989 • 176 citations

Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6

1994 • 176 citations

Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636

1990 • 173 citations

Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility

1976 • 172 citations

Plasmid-Mediated Resistance to Third-Generation Cephalosporins Caused by Point Mutations in TEM-Type Penicillinase Genes

1988 • 172 citations

Beta-lactamase-mediated imipenem resistance in Bacteroides fragilis

1986 • 169 citations

The diversity of the catalytic properties of class A β-lactamases

1990 • 169 citations

Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae

1990 • 166 citations

Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta-lactamase II

1990 • 164 citations

Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases

1994 • 161 citations

Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K.

1978 • 159 citations

Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli

1993 • 158 citations

Sequence of PSE-2 beta-lactamase

1988 • 156 citations

Biochemical characterization of a beta-lactamase that hydrolyzes penems and carbapenems from two Serratia marcescens isolates

1990 • 155 citations

Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins

1983 • 154 citations

Molecular Specificities of R Factor-Determined Beta-Lactamases: Correlation with Plasmid Compatibility

1974 • 153 citations

Sequence analysis of the L1 metallo-β-lactamase from Xanthomonas maltophilia

1994 • 153 citations

Biochemical properties of a carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli

1993 • 150 citations

Types of beta-lactamase determined by plasmids in gram-negative bacteria

1979 • 150 citations

Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose

1984 • 147 citations

Zinc as a Cofactor for Cephalosporinase from Bacillus cereus 569

1966 • 144 citations

Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species

1993 • 142 citations

Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases

1994 • 141 citations

Phylogeny of LCR‐1 and OXA‐5 with class A and class D β‐lactamases

1992 • 140 citations

RESISTANCE TO PENICILLINS AND ITS TRANSFER IN ENTEROBACTERIACEÆ

1965 • 140 citations

Multiply resistant Klebsiella pneumoniae strains from two Chicago hospitals: identification of the extended-spectrum TEM-12 and TEM-10 ceftazidime-hydrolyzing beta-lactamases in a single isolate

1994 • 137 citations

Novel plasmid-mediated beta-lactamase from Escherichia coli that inactivates oxyimino-cephalosporins

1988 • 136 citations

A survey of the kinetic parameters of class C β-lactamases. Cephalosporins and other β-lactam compounds

1988 • 136 citations

Close amino acid sequence relationship between the new plasmid-mediated extended-spectrum β-lactamase MEN-1 and chromosomally encoded enzymes of Klebsiella oxytoca

1992 • 135 citations

Sequence and comparative analysis of three Enterobacter cloacae ampC β-lactamase genes and their products

1988 • 133 citations

The purification and properties of a penicillinase whose synthesis is mediated by an R-factor in Escherichia coli

1966 • 133 citations

Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC β-lactamase

1990 • 129 citations

Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria

1982 • 124 citations

Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors

1994 • 123 citations

Nucleotide sequences of the genes coding for the TEM-like β-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2)

1994 • 122 citations

Drug Resistance of Enteric Bacteria

1968 • 120 citations

Clinical isolates of Escherichia coli producing TRI β-lactamases: novel TEM-enzymes conferring resistance to β-lactamase inhibitors

1992 • 119 citations

Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors

1988 • 118 citations

SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams

1989 • 117 citations

Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics

1989 • 117 citations

The Purification and Properties of Penicillin β-Lactamases Mediated by Transmissible R Factors in Escherichia coli

1969 • 113 citations

Properties of novel beta-lactamase produced by Bacteroides fragilis

1983 • 113 citations

Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae

1985 • 112 citations

AMPICILLIN TREATMENT FAILURE OF APPARENTLY β-LACTAMASE-NEGATIVE HAEMOPHILUS INFLUENZAE TYPE b MENINGITIS DUE TO NOVEL β-LACTAMASE

1981 • 112 citations

OBSERVATIONS ON THE NATURE, DISTRIBUTION, AND SIGNIFICANCE OF CEPHALOSPORINASE

1963 • 112 citations

Metal cofactor requirement of β-lactamase II

1974 • 111 citations

Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants

1994 • 111 citations

Cloning and sequencing of the metallothioprotein beta-lactamase II gene of Bacillus cereus 569/H in Escherichia coli

1985 • 110 citations

Plasmid-Mediated -Lactamase (TEM-7) Involved in Resistance to Ceftazidime and Aztreonam

1988 • 107 citations

Microbial Drug Resistance

1955 • 107 citations

[41] Nearest neighbor procedure for relating progressively aligned amino acid sequences

1990 • 107 citations

Novel R-factor borne β-lactamase of Escherichia coli confering resistance to cephalosporins

1987 • 106 citations

Direct sequencing of the amplified structural gene and promoter for the extended-broad-spectrum β-lactamase TEM-9 (RHH-1) of Klebsiella pneumoniae

1990 • 106 citations

Resistance of Escherichia coli to Penicillins VI. Purification and Characterization of the Chromosomally Mediated Penicillinase Present in ampA -Containing Strains

1970 • 106 citations

Sequence of the OXA2 β‐lactamase: comparison with other penicillin‐reactive enzymes

1985 • 105 citations

Single amino acid substitution between SHV‐1 β‐lactamase and cefotaxime‐hydrolyzing SHV‐2 enzyme

1988 • 105 citations

Novel plasmid-mediated beta-lactamase in clinical isolates of Klebsiella pneumoniae more resistant to ceftazidime than to other broad-spectrum cephalosporins

1988 • 104 citations

Antimicrobial Resistance in Bacteroides

1993 • 101 citations

A survey of the kinetic parameters of class C β-lactamases. Penicillins

1988 • 100 citations

The amino acid sequence of Staphylococcus aureus penicillinase

1975 • 98 citations

Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitumβ‐lactamase genes cloned from a natural isolate and a high‐level β‐lactamase producer

1994 • 98 citations

Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873

1984 • 98 citations

Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam

1993 • 98 citations

A comparative study of class-D β-lactamases

1993 • 97 citations

The acyl-enzyme mechanism of β-lactamase action. The evidence for class C β-lactamases

1982 • 96 citations

Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases

1993 • 96 citations

Characterization of four beta-lactamases produced by Staphylococcus aureus

1992 • 93 citations

Complete amino acid sequence of p453-plasmid-mediated PIT-2 β-lactamase (SHV-1)

1988 • 92 citations

Five novel plasmid-determined beta-lactamases

1985 • 92 citations

Sequence of the Citrobacter freundii OS60 chromosomal ampC beta-lactamase gene

1986 • 89 citations

Biochemical characterization of the metallo-beta-lactamase CcrA from Bacteroides fragilis TAL3636

1992 • 88 citations

Cloning, nucleotide sequence, and expression of the Bacillus cereus 5/B/6 beta-lactamase II structural gene

1988 • 85 citations

Purification and characterization of inducible beta-lactamases in Aeromonas spp

1990 • 85 citations

Acquisition of substrate-specific parameters during the catalytic reaction of penicillinase.

1976 • 85 citations

Methodology for the study of beta-lactamases

1986 • 85 citations

The production and molecular properties of the zinc β-lactamase of Pseudomonas maltophilia IID 1275

1985 • 82 citations

Close evolutionary relationship between the chromosomally encoded β lactamase gene of Klebsiellapneumoniae and the TEM β‐lactamase gene mediated by R plasmids

1986 • 82 citations

High specificity of cphA-encoded metallo-beta-lactamase from Aeromonas hydrophila AE036 for carbapenems and its contribution to beta-lactam resistance

1993 • 81 citations

Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae

1989 • 78 citations

Biochemical properties of beta-lactamase produced by Flavobacterium odoratum

1985 • 77 citations

Conjugal transfer of imipenem resistance in Bacteroides fragilis.

1992 • 76 citations

R-Factor-Mediated β-Lactamases That Hydrolyze Oxacillin: Evidence for Two Distinct Groups

1974 • 75 citations

An animal source for the ROB-1 beta-lactamase of Haemophilus influenzae type b

1986 • 74 citations

Purification and properties of a new beta-lactamase from Pseudomonas cepacia

1980 • 74 citations

Site-saturation studies of beta-lactamase: production and characterization of mutant beta-lactamases with all possible amino acid substitutions at residue 71.

1986 • 73 citations

Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids

1989 • 73 citations

Spread ofklebsiella pneumoniae producing SHV-5 beta-lactamase among hospitalized patients

1993 • 73 citations

Comparative Inhibition of β-Lactamases by Novel β-Lactam Compounds

1979 • 73 citations

Some Properties of Two Extracellular β-Lactamases from Bacillus cereus 569/H

1967 • 73 citations

Active sites of β-lactamases. The chromosomal β-lactamases of Pseudomonas aeruginosa and Escherichia coli

1982 • 72 citations

Role of the beta-lactamase of Campylobacter jejuni in resistance to beta-lactam agents

1991 • 72 citations

Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species

1992 • 72 citations

Ceftazidime: in-vitro antibacterial activity and susceptibility to -lactamases compared with that of cefotaxime, moxalactam and other -lactam antibiotics

1981 • 71 citations

Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme

1994 • 70 citations

Genetic Organization of Antibiotic Resistance Genes (aac(6′)-lb, aadA, and oxa9) in the Multiresistance Transposon Tn1331

1993 • 70 citations

Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase

1992 • 66 citations

Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 beta-lactamase genes

1992 • 66 citations

Properties of PSE-2 beta-lactamase and genetic basis for its production in Pseudomonas aeruginosa

1983 • 65 citations

Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

1994 • 64 citations

Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with the Staphylococcus aureus PC1 beta-lactamase crystal structure.

1990 • 64 citations

β-Lactamases with high activity against imipenem and Sch 34343 from Aeromonas hydrophila

1986 • 62 citations

Characterization of the plasmid-mediated β-lactamase in Branhamella catarrhalis, with special reference to substrate affinity

1985 • 62 citations

Spread of a "Pseudomonas-specific" beta-lactamase to plasmids of enterobacteria

1982 • 61 citations

Characterization of a plasmid-borne and constitutively expressed blamox-1 gene encoding AmpC-type β-lactamase

1994 • 60 citations

Characterization of eight beta-lactamases of Gram-negative bacteria

1982 • 59 citations

TRC-1: Emergence of a clavulanic acid-resistant TEM β-lactamase in a clinical strain

1992 • 58 citations

Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid

1990 • 58 citations

Identification of a novel plasmid-mediated β-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae

1993 • 58 citations

Biochemical properties of inducible beta-lactamases produced from Xanthomonas maltophilia

1994 • 58 citations

Role of lysine‐67 in the active site of class C β‐lactamase from Citrobacter freundii GN346

1990 • 58 citations

Susceptibility Patterns and Resistance to Imipenem in the Bacteroides fragilis Group Species in Japan: A 4-Year Study

1993 • 56 citations

Plasmid-mediated ROB-1 beta-lactamase in Pasteurella multocida from a human specimen

1991 • 55 citations

Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase

1994 • 55 citations

Recent Developments in -Lactamase Research and Their Implications for the Future

1988 • 55 citations

Transposition of the gene encoding a TEM-12 extended-spectrum beta-lactamase

1992 • 54 citations

Mechanisms of resistance to beta-lactam antibiotics.

1991 • 54 citations

TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli

1989 • 54 citations

Plasmid-determined beta-lactamase indistinguishable from the chromosomal beta-lactamase of Escherichia coli

1976 • 53 citations

beta-Lactamases of Branhamella catarrhalis and their inhibition by clavulanic acid

1982 • 53 citations

Purification and properties of a novel beta-lactamase from Fusobacterium nucleatum

1985 • 53 citations

A Novel Chromosomal TEM Derivative and Alterations in Outer Membrane Proteins Together Mediate Selective Ceftazidime Resistance in Escherichia coli

1990 • 52 citations

β-Lactamase of Pseudomonas pseudomallei and its contribution to antibiotic resistance

1987 • 52 citations

The active site of the P99 β-lactamase from Enterobacter cloacae

1984 • 51 citations

Biochemical characteristics of extended broad spectrum β-lactamases

1989 • 51 citations

R FACTORS, BETA-LACTAMASE, AND CARBENICILLIN-RESISTANT PSEUDOMONAS ÆRUGINOSA

1971 • 51 citations

Genetically diverse ceftazidime-resistant isolates from a single center: biochemical and genetic characterization of TEM-10 beta-lactamases encoded by different nucleotide sequences

1993 • 51 citations

Properties of three carbenicillin-hydrolysing β-lactamases (CARB) from Pseudomonas aeruginosa: identification of a new enzyme

1981 • 50 citations

Cloning and nucleotide sequencing of the gene encoding the β-lactamase from Citrobacter diversus

1991 • 49 citations

Nucleotide sequence of a new class A β-lactamase gene from the chromosome of Yersinia enterocolitica: Implications for the evolution of class A β-lactamases

1991 • 48 citations

Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS

1994 • 48 citations

Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase

1990 • 48 citations

Characterization of the plasmid mediated β-lactamase BIL-1

1992 • 48 citations

Sequence of the PSE-1 β-Lactamase Gene

1991 • 47 citations

Properties of a new penicillinase type produced by Bacteroides fragilis

1982 • 47 citations

Nucleotide sequence and phylogeny of SHV-2 beta-lactamase

1990 • 47 citations

The phototrophic bacterium Rhodopseudomonas capsulata sp108 encodes an indigenous class A β-lactamase

1989 • 47 citations

Cloning and Sequence Determination of Six Staphylococcus aureus -Lactamases and Their Expression in Escherichia coli and Staphylococcus aureus

1989 • 47 citations

Enzyme nomenclature, 1984

1985 • 46 citations

Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase

1989 • 45 citations

Purification and properties of beta-lactamase from Proteus morganii

1977 • 44 citations

Characterization of a β-lactamase from Clostridium clostridioforme

1994 • 43 citations

In vitro and in vivo activities of SCE-2787, a new parenteral cephalosporin with a broad antibacterial spectrum

1992 • 43 citations

A Plasmid-Mediated Cepbalosporinase from Achromobacter Species

1982 • 42 citations

Purification and Properties of Chromosomally Mediated -Lactamase from Citrobacter freundii GN7391

1980 • 42 citations

Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins

1980 • 42 citations

Chromosomally encoded cephalosporin-hydrolyzing β-lactamase of Proteus vulgaris RO104 belongs to Ambler's class A

1994 • 41 citations

Contribution of enzymatic properties, cell permeability, and enzyme expression to microbiological activities of beta-lactams in three Bacteroides fragilis isolates that harbor a metallo-beta-lactamase gene

1994 • 41 citations

.BETA.-Lactamase and .BETA.-lactam antibiotics resistance in Acinetobacter anitratum (syn.: A. Calcoaceticus).

1977 • 41 citations

Properties of the β-lactamase specified by thePseudomonasplasmid R151

1978 • 41 citations

Chromosomal beta-lactamase expression and resistance to beta-lactam antibiotics in Proteus vulgaris and Morganella morganii

1988 • 40 citations

Beta-lactam antibiotics for clinical use

1987 • 40 citations

Nucleotide sequence of a plasmid-mediated cephalosporinase gene (blaLAT-1) found in Klebsiella pneumoniae

1994 • 40 citations

Plasmid-mediated beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to ceftazidime

1989 • 39 citations

Purification and properties of beta-lactamase from Bacteroides fragilis

1978 • 39 citations

Purification and properties of a constitutive β-lactamase from Pseudomonas aeruginosa strain dalgleish

1975 • 39 citations

Nucleotide sequence of the Serratia marcescens SR50 chromosomal ampC β-lactamase gene

1990 • 38 citations

Properties of a class C β-lactamase from Serratia marcescens

1986 • 38 citations

Characterization of three different beta-lactamases from the Bacteroides fragilis group

1980 • 37 citations

Identification of CTX-2, a novel cefotaximase from a Salmonella mbandaka isolate

1991 • 37 citations

Acquired resistance of Nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid

1991 • 37 citations

Characterization of a beta-lactamase found in Eikenella corrodens

1991 • 37 citations

Comparison of the Substrate Specificities of the β-Lactamases from Klebsiella aerogenes 1082E and Enterobacter cloacae P99

1972 • 37 citations

Beta-Lactam Antibiotics for Clinical Use.

1986 • 37 citations

Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 β-lactamase of Pseudomonas aeruginosa

1991 • 37 citations

Escherichia coli chromosomal mutations that permit direct cloning of the Bacteroides fragiiis metallo‐β‐lactamase gene, ccrA

1991 • 37 citations

Convergent evolution of TEM-26, a β-lactamase with extended-spectrum activity

1994 • 36 citations

Isolation and characterization of a penicillinase from Pseudomonas cepacia 249

1988 • 36 citations

Comparative study of a novel plasmid-mediated beta-lactamase, CAZ-2, and the CTX-1 and CAZ-1 enzymes conferring resistance to broad-spectrum cephalosporins

1988 • 36 citations

Characterization and amino acid sequence of IRT-4, a novel TEM-type enzyme with a decreased susceptibility to β-lactamase inhibitors

1994 • 36 citations

Properties of the Beta-Lactamase Specified by the Pseudomonas Plasmid RPL11

1977 • 36 citations

Purification and properties of cephalosporinase in Escherichia coli

1980 • 36 citations

Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime.

1988 • 36 citations

Properties of a novel carbenicillin-hydrolyzing beta-lactamase (CARB-4) specified by an IncP-2 plasmid from Pseudomonas aeruginosa

1986 • 35 citations

Plasmid penicillin resistance in Vibrio cholerae: identification of new beta-lactamase SAR-1

1986 • 35 citations

Biochemical Properties of a Cephalosporin β‐Lactamase from Pseudomonas aeruginosa

1973 • 35 citations

Biochemical properties of beta-lactamase produced by Legionella gormanii

1986 • 34 citations

Novel beta-lactamase from Capnocytophaga sp

1990 • 34 citations

Sequences of MGH-1, YOU-1, and YOU-2 extended-spectrum beta-lactamase genes

1993 • 33 citations

In-vitro activity of the monobactam, SQ 26,776, against Gram-negative bacteria and its stability to their -lactamases

1981 • 33 citations

Characterisation of a novel plasmid-mediated β-lactamase and its contribution to β-lactam resistance inPseudomonas aeruginosa

1983 • 33 citations

Detection of PSE-2 beta-lactamase in enterobacteria

1984 • 31 citations

The amino acid sequence of penicillinase from Bacillus licheniformis

1969 • 31 citations

Nucleotide sequence of the gene encoding the active-site serine β-lactamase fromStreptomyces cacaoi

1988 • 31 citations

Characterization of cell-bound papain-soluble beta-lactamases in BRO-1 and BRO-2 producing strains ofMoraxella (Branhamella) catarrhalis andMoraxella nonliquefaciens

1992 • 31 citations

Overproduced -Lactamase and the Outer-membrane Barrier as Resistance Factors in Serratia marcescens Highly Resistant to -Lactamase-stable -Lactam Antibiotics

1989 • 30 citations

Characterization of a β-lactamase produced in Mycobacterium fortuitum D316

1990 • 30 citations

Novel plasmid-mediated beta-lactamase in members of the family Enterobacteriaceae from Ohio

1986 • 30 citations

Comparative study of five plasmid-mediated ceftazidimases isolated in Klebsiella pneumoniae

1989 • 30 citations

Cefotaxime-hydrolysing activity of the β-lactamase ofKlebsiella oxytocaD488 could be related to a threonine residue at position 140

1991 • 30 citations

Characterization of NPS-1, a novel plasmid-mediated beta-lactamase, from two Pseudomonas aeruginosa isolates

1986 • 29 citations

Purification and properties of cephalosporinase from Pseudomonas aeruginosa.

1981 • 28 citations

-Lactamase Activity in Chromobacterium violaceum

1976 • 28 citations

Novel R-Plasmid-Mediated Beta-Lactamase from Klebsiella aerogenes

1977 • 28 citations

Genetic and biochemical properties of AER-1, a novel carbenicillin-hydrolyzing beta-lactamase from Aeromonas hydrophila

1985 • 28 citations

Novel carbenicillin-hydrolyzing β-lactamase (CARB-5) from Acinetobacter calcoaceticus var. anitratus

1989 • 28 citations

Cefoxitin resistance by a chromosomal cephalosporinase in Escherichia coli.

1980 • 28 citations

Characterization of the membrane .beta.-lactamase in Bacillus cereus 569/H/9

1983 • 27 citations

The K1 β-lactamase of Klebsiella pneumoniae

1987 • 27 citations

Protein and carbohydrate moieties of a preparation of β-lactamase II

1971 • 27 citations

Kinetic properties of two plasmid-mediated β-lactamases from Klebsiella pneumoniae with strong activity against third-generation cephalosporins

1988 • 27 citations

Isolation and Properties of an Inducible and a Constitutive ss- Lactamase from Pseudomonas aeruginosa

1982 • 27 citations

Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis

1991 • 26 citations

A set of bacterial strains for evaluation of .BETA.-lactamase-stability of .BETA.-lactam antibiotics.

1981 • 26 citations

Production of a variant of β-lactamase II with selectively decreased cephalosporinase activity by a mutant of Bacillus cereus 569/H/9

1980 • 26 citations

beta-lactamase from Streptomyces cacaoi. Purification and properties.

1981 • 26 citations

Cloning of chromosomal β-lactamase genes from Yersinia enterocolitica

1991 • 25 citations

Some relationships between R-factor and chromosomal β-lactamase in Gram-negative bacteria

1971 • 24 citations

Cloning and expression of the gene(s) for cephalosporinase production of Citrobacter freundii

1983 • 24 citations

Partial characterization of Nocardia farcinica beta-lactamases

1993 • 24 citations

Properties of cephalosporinase from Proteus morganii.

1981 • 24 citations

Purification and characterization of a new beta-lactamase from Clostridium butyricum

1989 • 23 citations

Citrobacter diversus ULA-27 β-lactamases. Improved purification and general properties

1988 • 23 citations

Induction of -Lactamase in Proteus vulgaris

1986 • 23 citations

Cefoxitin, N-formimidoyl thienamycin, clavulanic acid, and penicillanic acid sulfone as suicide inhibitors for different types of .BETA.-lactamases produced by gram-negative bacteria.

1982 • 23 citations

Purification and biochemical properties of beta-lactamase produced by Proteus rettgeri

1980 • 22 citations

Characterization of a -lactamase produced by Pseudomonas paucimobilis

1991 • 22 citations

Purification of .BETA.-lactamase from Streptomyces cellulosae by affinity chromatography on blue sepharose.

1979 • 22 citations

Susceptibility of Rhodobacter sphaeroides to beta-lactam antibiotics: isolation and characterization of a periplasmic beta-lactamase (cephalosporinase)

1989 • 22 citations

Extended spectrum β-lactamase from Klebsiella oxytoca, not belonging to the TEM or SHV family

1992 • 22 citations

Nucleotide sequence of the gene encoding the active-site serine β-lactamase fromActinomaduraR39

1989 • 22 citations

Novel transferable extended-spectrum β-lactamase (SHV-6) fromKlebsiella pneumoniaeconferring selective resistance to ceftazidime

1991 • 22 citations

New plasmid-mediated oxacillin-hydrolyzing β-lactamase in Pseudomonas aeruginosa

1986 • 22 citations

Characteristics of a β-Iactamase produced by Clostridium butyricum

1982 • 22 citations

The .BETA.-lactamases of genus Bacteroides.

1983 • 22 citations

Sequence analysis of the ROB-1 ß-lactamase gene from Actinobacillus pleuropneumoniae

1992 • 21 citations

Substrate-induced inactivation of the OXA2 β-lactamase

1993 • 21 citations

A -β-lactamase-overproducing strain of Alcaligenes denitrificans subsp. xylosoxydans isolated from a case of meningitis

1992 • 21 citations

Carbenicillin‐Hydrolyzing Penicillinases of Proteus mirabilis and the PSE‐Type Penicillinases of Pseudomonas aeruginosa

1983 • 20 citations

Interactions between active‐site serine β‐lactamases and so‐called β‐lactamase‐stable antibiotics

1993 • 20 citations

Plasmid-Determined Beta-Lactamases

1989 • 20 citations

Distinct plasmid profiles of Pasteurella haemolytica serotypes and the characterization and amplification in Escherichia coli of ampicillin-resistance plasmids encoding ROB-1 -lactamase

1992 • 20 citations

The active sites of the β-lactamases of Streptomyces cacaoi and Streptomyces albus G.

1987 • 20 citations

Purification and characterization of an extracellular -lactamase produced by Acinetobacter calcoaceticus

1992 • 19 citations

Sequences of CAZ-3 and CTX-2 extended-spectrum beta-lactamase genes

1994 • 19 citations

β-Lactamase types amongst Staphylococcus aureus isolates in relation to susceptibility to β-lactamase inhibitor combinations

1994 • 19 citations

Evolutionary origin of the class A and class C ?-lactamases

1992 • 19 citations

Nucleotide sequence and transcriptional analysis of activator-regulator proteins for beta-lactamase in Streptomyces cacaoi

1992 • 18 citations

Isolation and partial purification of a carbapenem-hydrolysing metallo-β-lactamase fromPseudomonas cepacia

1994 • 18 citations

Extension of the substrate spectrum by an amino acid substitution at residue 219 in the Citrobacter freundii cephalosporinase

1990 • 18 citations

Phylogenetic Tree and Sequence Similarity of β-Lactamases

1993 • 17 citations

Timentin and -lactamases

1986 • 17 citations

Characterisation of a unique ceftazidime-hydrolysing -lactamase, TEM-E2

1990 • 17 citations

Purification and properties of a .BETA.-lactamase from Proteus penneri.

1986 • 16 citations

Effect of clavulanic acid on activity of beta-lactam antibiotics in Serratia marcescens isolates producing both a TEM beta-lactamase and a chromosomal cephalosporinase

1991 • 16 citations

Structural and kinetic studies on β-lactamase K1 from Klebsiella aerogenes

1986 • 16 citations

Interaction of β-Lactam Antibiotics with β-Lactamases as a Cause for Resistance

1984 • 16 citations

Purification and properties of the exocellular β-lactamase of a Actinomadura strain R39

1982 • 16 citations

Sedimentation-equilibrium studies on the heterogeneity of two β-lactamases

1970 • 16 citations

A membrane-bound precursor β-lactamase in strains of Moraxella catarrhalis and Moraxella nonliquefaciens that produce peripiasmic BRO-1 and BRO-2 β-lactamases

1993 • 15 citations

Comparative amino acid contents of purified β‐lactamases from enteric bacteria

1970 • 15 citations

R-Mediated β-Lactamases and Episomal Resistance to the β-Lactam Drugs in Different Bacterial Hosts

1974 • 15 citations

Two novel transferable extended-spectrum β-lactamases from Klebsiella pneumoniae in Tunisia

1990 • 15 citations

Covalent binding of moxalactam to cephalosporinase of Citrobacter freundii

1985 • 15 citations

-Lactamase of Lysobacter Enzymogenes: Induction, Purification and Characterization

1990 • 15 citations

Interactions between non-classical β-lactam compounds and the β-lactamases of Actinomadura R39 and Streptomyces albus G

1981 • 14 citations

Characterization of chromosomally encoded penicillinases in clinical isolates of Klebsiella pneumoniae

1992 • 14 citations

The effect of amino acid substitution at position 219 of Citrobacter freundii cephalosporinase on extension of its substrate spectrum

1992 • 14 citations

A class-A β-lactamase from Pseudomonas stutzeri that is highly active against monobactams and cefotaxime

1993 • 14 citations

Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins

1993 • 13 citations

Properties of the beta-lactamase (penicillinase) produced byLevinea malonatica

1980 • 13 citations

Two variants of transferrable extended-spectrum TEM-β-lactamase successively isolated from a clinical Escherichia coli isolate

1992 • 13 citations

The combination of pivmecillinam and pivampicillin in the treatment of acute enteric fever

1981 • 12 citations

Improved purification and characterization of the OXA-2 β-lactamase

1984 • 12 citations

Chromosome-encoded β-lactamases of Citrobacter diversus. Interaction with β-iodopenicillanate and labelling of the active site

1988 • 12 citations

Purification and Properties of -Lactamases from Serratia marcescens

1981 • 12 citations

-Lactamase of Lysobacter enzymogenes: cloning, characterization and expression of the gene and comparison of the enzyme to other lactamases

1993 • 12 citations

Purification and properties of a beta-lactamase produced by Branhamella catarrhalis

1986 • 12 citations

R-plasmid mediated transfer of .BETA.-lactam resistance in Bacteroides fragilis.

1990 • 12 citations

In vitro and in vivo Transferrable β‐Lactam Resistance Due to a New Plasmid‐Mediated Oxyiminocephalosporinase from a Clinical Isolate of Proteus mirabilis

1991 • 11 citations

Identification of the active site of Citrobacter freundii β‐lactamase using dansyl‐penicillin

1987 • 11 citations

A survey of a functional amino acid of class Cβ‐lactamase corresponding to Glu¹⁶⁶ of class A β‐lactamases

1993 • 10 citations

Purification and properties of a cephalosporinase from Acinetobacter calcoaceticus.

1989 • 10 citations

Fractionation and characterization of two β-lactamases in Citrobacter diversus ULA-27 strain by chromatofocusing

1987 • 10 citations

The mechanism of mycobacterial resistance to penicillins and cephalosporins.

1970 • 9 citations

Sequence of a gene encoding β-lactamase from Streptomyces cellulosae

1993 • 9 citations

Interaction of β-lactamases I and II from Bacillus cereus with semisynthetic cephamycins. Kinetic studies

1991 • 8 citations

Biochemical Characterization of Type A and Type B -Lactamase from Enterobacter cloacae

1988 • 8 citations

A simple method for testing the efficacy of a .BETA.-lactamase inhibitor against .BETA.-lactamase-producing gram-negative bacteria.

1982 • 8 citations

Céphalosporinases constitutives de Escherichia coli

1976 • 8 citations

Identification and characterization of a novel β-lactamase TLE-2, encoded by plasmid pUK702

1987 • 7 citations

Two different β-lactamase genes are present in Streptomycees cacaoi

1992 • 7 citations

Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391

1989 • 7 citations

Biochemical, immunological and physicochemical comparisons between OHIO-1 and four SHV-type β-lactamases

1989 • 6 citations

Interaction of .BETA.-lactamase of Streptomyces cacaoi. I. Clavulanic acid and PS-5.

1981 • 6 citations

Purification and properties of inducible penicillin beta-lactamase isolated from Alcaligenes faecalis

1985 • 6 citations

Oxacillin hydrolysis by the LCR-1 beta-lactamase

1995 • 5 citations

SAR-2: Identification of a novel plasmid-encoded β-lactamase from India

1989 • 4 citations

Purification of a class C A-type β-lactamase from a derepressed strain of Enterobacter cloacae. Comparison of the wild-type and mutant enzyme with those from strains P99, 208 and GN7471

1989 • 4 citations

Chromosomally-mediated β-lactamases produced by Levinea amalonatica with activity against methoxyimino-cephalosporins

1991 • 4 citations

Purification and properties of a chromosomal .BETA.-lactamase from Klebsiella oxytoca.

1991 • 4 citations

[Constitutive cephalosporinases from "Escherichia coli" (author's transl)].

1976 • 3 citations

[Identification of a new penicillinase in a Klebsiella pneumoniae strain of which a mutant also produces an esterase hydrolyzing cephalothin and cefotaxime].

1992 • 2 citations

The kinetics of CAZ-5, a novel SHV-related plasmid-mediated beta-lactamase with enhanced hydrolytic activity against ceftazidime.

1989 • 2 citations

LXA-1: a new plasmid-mediated β-lactamase giving low-level resistance

1988 • 2 citations

Inducible oxacillin-hydrolyzing β-lactamase in a methylotrophic bacterium

1988 • 1 citations

beta-Lactamase Id of ceftazidime-resistant Pseudomonas aeruginosa strains.

1992 • 1 citations

Properties of the beta-lactamase (penicillinase) produced by Levinea malonatica

1980 • 1 citations

Carbenicillin-hydrolyzing .BETA.-lactamase produced by Corynebacterium pseudodiphtheriticum.

1985 • 1 citations

Purification and Properties of an Unusual Cephalosporinase Specified by an R Plasmid in Escherichia Coli

1975 • 1 citations