Methodology for the study of beta-lactamases

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters

1974 • 1,571 citations

Antimicrobial-Drug Resistance

1996 • 1,087 citations

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

1978 • 399 citations

Naturally-occurring .BETA.-lactamase inhibitors with antibacterial activity.

1976 • 388 citations

Suicide enzyme inactivators

1976 • 366 citations

A spectrophotometric assay of β-lactamase action on penicillins

1974 • 266 citations

Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia

1982 • 234 citations

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

1985 • 223 citations

.beta.-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin

1980 • 222 citations

Kinetic studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1978 • 204 citations

Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams

1985 • 182 citations

PURIFICATION AND PROPERTIES OF PENICILLINASES FROM TWO STRAINS OF BACILLUS LICHENIFORMIS: A CHEMICAL, PHYSICOCHEMICAL AND PHYSIOLOGICAL COMPARISON

1965 • 178 citations

The inhibition of class C β-lactamases by boronic acids

1983 • 154 citations

Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose

1984 • 147 citations

Identification of -Lactamases by Analytical Isoelectric Focusing: Correlation with Bacterial Taxonomy

1976 • 145 citations

A direct spectrophotometric assay and determination of Michaelis constants for the β-lactamase reaction

1975 • 144 citations

Zinc as a Cofactor for Cephalosporinase from Bacillus cereus 569

1966 • 144 citations

A Comparative Study of Eight Distinct -Lactamases Synthesized by Gram-negative Bacteria

1970 • 130 citations

Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria

1982 • 124 citations

Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae

1985 • 112 citations

Inactivation of the RTEM .beta.-lactamase from Escherichia coli. Interaction of penam sulfones with the enzyme

1981 • 110 citations

Monobactams--monocyclic -lactam antibiotics produced by bacteria

1981 • 100 citations

β‐Lactamase inhibitors

1983 • 90 citations

Characterization of beta-lactamase induction in Enterobacter cloacae

1983 • 74 citations

β-Lactamase inhibitors in perspective

1983 • 61 citations

Do β-lactamases ‘trap’ cephalosporins?

1985 • 49 citations

Comparison of assay techniques for β-lactamase activity

1973 • 45 citations

Induction Kinetics of β-Lactamase Biosynthesis in Pseudomonas aeruginosa

1974 • 32 citations

Purification and properties of inducible penicillin β-lactamase isolated from Pseudomonas maltophilia

1985 • 30 citations

Induction of -Lactamase in Proteus vulgaris

1986 • 23 citations

Induction of cephalosporinase production by various penicillins in Enterobacteriaceae.

1983 • 17 citations

Interaction of β-Lactam Antibiotics with β-Lactamases as a Cause for Resistance

1984 • 16 citations

Screening and Characterization of Enzyme Inhibitors as Drug Candidates

1983 • 14 citations

Classification of ß-Lactamase-Producing Bacteria

1982 • 2 citations