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Carcinogenesis and Its Modification by Environmental Endocrine Disruptors: In Vivo Experimental and Epidemiological Findings

Data up to Jan 2025

Published2003
Citations25
References171

Total Citations Per Year

Abstract

References (171)

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Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan

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1997 • 117 citations

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Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agroecosystems, 1987-1991

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Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones.

1996 • 116 citations

Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and white women in North Carolina.

2000 • 116 citations

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1998 • 115 citations

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2001 • 114 citations

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1998 • 114 citations

Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats

1999 • 114 citations

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1998 • 111 citations

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2000 • 109 citations

Soy Isoflavones Increase Latency of Spontaneous Mammary Tumors in Mice

2002 • 109 citations

Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats

1992 • 107 citations

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2001 • 106 citations

Effects of Di-isononyl Phthalate, Di-2-ethylhexyl Phthalate, and Clofibrate in Cynomolgus Monkeys

2000 • 105 citations

DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer

1999 • 101 citations

Dietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats

2002 • 101 citations

Correlation Analysis of Pesticide Use Data and Cancer Incidence Rates in California Counties

1998 • 100 citations

Circulating enterolactone and prostate cancer risk: A Nordic nested case‐control study

2002 • 99 citations

Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium

1998 • 99 citations

Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice

1999 • 98 citations

Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet

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A prospective cohort study of soy product intake and stomach cancer death

2002 • 97 citations

Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones

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Dietary Soybean Isolate and Methionine Supplementation Affect Mammary Tumor Progression in Rats

1991 • 94 citations

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2002 • 93 citations

Blood Levels of DDT and Breast Cancer Risk Among Women Living in the North of Vietnam

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2001 • 88 citations

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Effects of a Soybean Isoflavone Mixture on Carcinogenesis in Prostate and Seminal Vesicles of F344 Rats

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1988 • 85 citations

Influence of isoflavones in soy protein isolates on development of induced prostate‐related cancers in L‐W rats

1997 • 83 citations

Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside

2000 • 83 citations

Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats.

1990 • 83 citations

Regional Assessment of Atrazine Exposure and Incidence of Breast and Ovarian Cancers in Kentucky

2002 • 83 citations

Dose Effects of Flaxseed and Its Lignan on N-Methyl-N-Nitrosourea-Induced Mammary Tumorigenesis in Rats

1999 • 82 citations

A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan

1997 • 82 citations

Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats

2001 • 81 citations

Dose Response in Butylated Hydroxyanisole Induction of Forestomach Carcinogenesis in F344 Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 81 citations

Organochlorines and endometrial cancer risk.

2000 • 80 citations

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1994 • 79 citations

Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis

2000 • 79 citations

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Serum Organochlorine Pesticide Levels in Patients with Colorectal Cancer in Egypt

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Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced byN-methyl-N?-nitro-N-nitrosoguanidine in Wistar rats

1999 • 76 citations

The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse

1998 • 71 citations

The mammary tumor response in triazine-treated female rats: A threshold-mediated interaction with strain and species-specific reproductive senescence

1999 • 65 citations

Mortality in Male and Female Capacitor Workers Exposed to Polychlorinated Biphenyls

1999 • 65 citations

Preventive Effects of Isoflavones, Genistein and Daidzein, on Estradiol‐17β‐related Endometrial Carcinogenesis in Mice

2001 • 62 citations

Soy intake and other lifestyle determinants of serum estrogen levels among postmenopausal Chinese women in Singapore.

2002 • 62 citations

Promoting effects of 3-amino-1,2,4-triazole on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine

1982 • 61 citations

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1988 • 61 citations

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Exposure to Flaxseed or Purified Lignan During Lactation Influences Rat Mammary Gland Structures

2000 • 59 citations

Effect of miso (Japanese soybean paste) and NaCl on dmba‐induced rat mammary tumors

1990 • 57 citations

Inhibition of spontaneous hepatocarcinogenesis in C3H/HeN mice by Edi Pro A, an isolated soy protein

1981 • 56 citations

Organochlorine pesticides in carcinoma of the gallbladder: a case–control study

2001 • 53 citations

Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy

2001 • 53 citations

Inhibition of mouse skin tumor‐initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water

1991 • 53 citations

Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by a principal flavor component of Japanese-style fermented soy sauce.

1992 • 52 citations

Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p-p'-DDE, on methylnitrosourea-induced mammary tumor development in the rat.

2001 • 51 citations

Fusarium Mycotoxins in Corn and Corn Products in a High-Risk Area for Gastric Cancer in Shandong Province, China

1999 • 49 citations

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1997 • 49 citations

Detailed low‐dose study of 1,1‐b™IS(p‐chlorophenyl)‐2,2,2‐ trichloroethane carcinogenesis suggests the possibility of a hormetic effect

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Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats

1985 • 47 citations

Breast cancer risk factors: PCB congeners

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Serum levels of beta-hexachlorocyclohexane, hexachlorobenzene and polychlorinated biphenyls and breast cancer in Mexican women

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1990 • 41 citations

Anticarcinogenic Effects of Isoflavones May Be Mediated by Genistein in Mouse Mammary Tumor Virus-Induced Breast Cancer

2002 • 39 citations

Possible enhancing effects of atrazine and nonylphenol on 7,12‐dimethylbenz[a]anthracene‐induced mammary tumor development in human c‐Ha‐ras proto‐oncogene transgenic rats

2004 • 38 citations

Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver

1995 • 38 citations

Chemopreventive activity of crude hydroxsymatairesinol (HMR) extract in ApcMin mice

2000 • 37 citations

ROLE OF PROLACTIN IN CHLORO-S-TRIAZINE RAT MAMMARY TUMORIGENESIS

2000 • 37 citations

Inhibition of N-Acetyltransferase activity and DNA–2-Aminofluorene adducts by glycyrrhizic acid in human colon tumour cells

2000 • 37 citations

Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-γ, in caspase-dependent and -independent manners

2002 • 37 citations

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1979 • 36 citations

Modification of spontaneous mammary tumors in mice fed different sources of protein, fat and carbohydrate

1983 • 36 citations

Effects of long-term oral administration of DDT on nonhuman primates

1999 • 35 citations

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1984 • 34 citations

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2000 • 29 citations

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1991 • 28 citations

Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats

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2002 • 27 citations

Antitumorigenic Effects of Several Food Proteins in a Rat Model with Colon Cancer and Their Reverse Correlation with Plasma Bile Acid Concentration.

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Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine (DHPN)

2000 • 23 citations

Effects of the lignan, arctiin, on 17-beta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats.

1998 • 22 citations

Organochlorines and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) in Cancerous and Noncancerous Breast Tissue: Do the Data Support the Hypothesis That Oxidative DNA Damage Caused by Organochlorines Affects Breast Cancer?

2001 • 21 citations

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1978 • 20 citations

Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation

1991 • 18 citations

Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N‐bis(2‐hydroxypropyl)nitrosamine (DHPN)

2000 • 18 citations

Effects of soyabean and ascorbic acid on experimental carcinogenesis

1989 • 17 citations

Enhancement by sulpiride of the inhibitory effects of cysteamine on gastric carcinogenesis induced by n‐methyl‐n'‐nitro‐n‐nitrosoguanidine in wistar rats

1991 • 17 citations

The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia after X‐Irradiation of the Rat Glandular Stomach

1992 • 16 citations

Carcinogenicity testing of atrazine: preliminary report on a 13-month study on male Swiss albino mice treated by intraperitoneal administration.

1986 • 16 citations

Uterine Adenocarcinoma inN-Ethyl-N-nitro-N-nitrosoguanidine-treated Rats with High-dose Exposure to p-tert-Octylphenol during Adulthood

2002 • 13 citations

Inhibitory effect of butylated hydroxyanisole administration on pancreatic carcinogenesis in Syrian hamsters initiated with N-nitrosobis(2-oxopropyl)amine

1989 • 11 citations

Polychlorinated biphenyls promote 1‐nitropyrene‐induced lung tumorigenesis without the induction of K‐ras gene mutation in A/J mice

2001 • 10 citations

Tributyrin enhances the cytotoxic activity of interleukin-2/interleukin-12 stimulated human natural killer cells against LS 174T colon cancer cells in vitro

2001 • 10 citations

Lack of Modifying Effects of 4-n-Octylphenol on 3,2′-Dimethyl-4-aminobiphenyl-Induced Prostate Carcinogenesis in Rats

2002 • 6 citations

Inhibition by catechol and di(2-ethylhexyl)phthalate of pancreatic carcinogenesis after initiation with N-nitrosobis(2-hydroxypropyl)amine in Syrian hamsters

1994 • 5 citations

Influence of hormonal disturbances on transplacental and multigeneration carcinogenesis in rats.

1989 • 4 citations

Inhibition by 3-amino-1H-1,2,4-triazole of hepatic tumorigenesis induced by diethylstilbestrol alone or combined with N-nitrosobutylurea in WF rats.

1985 • 3 citations

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Carcinogenesis and Its Modification by Environmental Endocrine Disruptors: In Vivo… (2003) – Japanese Journal of Clinical Oncology | Metascience Observatory Explorer