Paraffin wax‐embedded material as a source of DNA for the detection of somatic genetic changes

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

1987 • 638 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

SAMPLE PREPARATION FROM PARAFFIN-EMBEDDED TISSUES

1990 • 565 citations

PCR Amplification from Paraffin-Embedded Tissues: Effects of Fixative and Fixation Time

1991 • 549 citations

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour

1984 • 538 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.

1988 • 343 citations

Gene losses in human tumours

1988 • 280 citations

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides

1987 • 260 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Amplification of a hightly polymorphic VNTR segment by the polymerase chain reaction

1989 • 244 citations

Accumulation of genetic alterations and progression of primary breast cancer.

1991 • 229 citations

Specific chromosome aberration in human renal cell carcinoma

1987 • 195 citations

Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.

1989 • 192 citations

Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology.

1988 • 190 citations

Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

1991 • 162 citations

Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.

1992 • 159 citations

Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma

1988 • 147 citations

Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas.

1990 • 144 citations

Cytogenetic studies in ovarian cancer

1984 • 131 citations

Simplified procedures for applying the polymerase chain reaction to routinely fixed paraffin wax sections.

1991 • 116 citations

Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.

1991 • 108 citations

Nonrandom chromosome alterations in human malignant mesothelioma.

1988 • 103 citations

Fundamental study on the mechanism of DNA degradation in tissues fixed in formaldehyde.

1990 • 99 citations

Recurring loss involving chromosomes 1, 3, and 22 in malignant mesothelioma: Possible sites of tumor suppressor genes

1989 • 99 citations

Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms (Part 1 of 27)

1991 • 98 citations

Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma

1991 • 97 citations

Implication of RARB in Epidermoid (Squamous) Lung Cancer

1991 • 83 citations

Nonrandom chromosome alterations in rhabdomyosarcoma

1985 • 80 citations

Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction

1991 • 60 citations

A deletion map of the WAGR region on chromosome 11.

1989 • 59 citations

Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall‐cell lung cancer

1989 • 58 citations

PCR-based RFLP analysis allows genotyping of the short arm of chromosome 3 in small biopsies from patients with lung cancer

1992 • 39 citations

Ordering three DNA polymorphisms on human chromosome 3 by sperm typing

1991 • 37 citations

Generation of clonal variants in a human ovarian carcinoma studied by chromosome banding analysis

1985 • 32 citations

Polymerase chain reaction: amplification of DNA from fixed tissue

1990 • 29 citations

New strategies in microbiological diagnosis

1991 • 16 citations

Polymerase chain reaction (PCR) for detection of Mspl polymorphism at the D3S6 locus

1991 • 13 citations

Polymerase chain reaction (PCR) for detection of Mspl and Dral polymorphism at the THRB gene

1991 • 10 citations

Polymerase chain reaction (PCR) for detection of BamHI polymorphism at the THRB gene

1991 • 9 citations

Polymerase chain reaction (PCR) for detection of Mspl polymorphism at the D3S2 locus

1991 • 9 citations

Polymerase chain reaction (PCR) for detection of HindIII polymorphism at the D3F15S2 locus.

1991 • 8 citations

Allele losses and onco‐suppressor genes

1991 • 7 citations

Polymerase chain reaction (PCR) for detection of Rsal polymorphism at the D3S32 locus

1991 • 7 citations

New Microbial Diagnosis

1991 • 4 citations

Polymerase chain reaction (PCR) for detection of Mspl polymorphism at the D3S30 locus

1991 • 1 citations