Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression

A review of central 5-HT receptors and their function

1999 • 3,121 citations

Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals

1991 • 2,094 citations

Guide to Receptors and Channels (GRAC), 5th edition

2011 • 2,066 citations

Looking for inspiration: new perspectives on respiratory rhythm

2006 • 801 citations

Ionotropic and metabotropic glutamate receptor structure and pharmacology

2005 • 758 citations

Opioids and the control of respiration

2008 • 716 citations

PREBÖTZINGER COMPLEX AND PACEMAKER NEURONS: Hypothesized Site and Kernel for Respiratory Rhythm Generation

1998 • 569 citations

Pronounced, Episodic Oxygen Desaturation in the Postoperative Period

1985 • 435 citations

Buprenorphine

1979 • 400 citations

Measured Context-sensitive Half-times of Remifentanil and Alfentanil

1995 • 400 citations

Distinct rhythm generators for inspiration and expiration in the juvenile rat

2005 • 376 citations

Opioid-Induced Glial Activation: Mechanisms of Activation and Implications for Opioid Analgesia, Dependence, and Reward

2007 • 349 citations

Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids

1993 • 331 citations

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats

2005 • 309 citations

Respiratory and haemodynamic effects of acute postoperative pain management: evidence from published data

2004 • 301 citations

Pharmacokinetics of Naloxone in Rats and in Man

1976 • 284 citations

Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker–network model

2000 • 275 citations

Opioids and the immune system

2006 • 269 citations

5-HT _4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia

2003 • 264 citations

Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat.

1991 • 250 citations

Respiratory depression associated with patient-controlled analgesia: a review of eight cases

1994 • 231 citations

Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

2005 • 229 citations

AMPA Receptor Potentiators for the Treatment of CNS Disorders

2004 • 222 citations

Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.

2003 • 217 citations

Postoperative Epidural Morphine Is Safe on Surgical Wards

1991 • 215 citations

Acute Pulmonary Edema Following Naloxone Reversal of High-dose Morphine Anesthesia

1977 • 212 citations

A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia

2001 • 208 citations

PRESENT STATE OF EXTRADURAL AND INTRATHECAL OPIOID ANALGESIA IN SWEDEN

1987 • 207 citations

Patient-Controlled Analgesia in the Management of Postoperative Pain

2006 • 207 citations

CLINICAL ACTIONS OF FENTANYL AND BUPRENORPHINE

1985 • 205 citations

A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

2007 • 199 citations

THE FIRST YEAR'S EXPERIENCE OF AN ACUTE PAIN SERVICE

1991 • 193 citations

Pharmacokinetic–Pharmacodynamic Modeling of Opioids

2005 • 192 citations

Serotonin receptors: guardians of stable breathing

2003 • 189 citations

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

2008 • 173 citations

Safety assessment of postoperative pain management by an acute pain service

1993 • 167 citations

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

2005 • 165 citations

Naloxone treatment in opioid addiction: the risks and benefits

2007 • 165 citations

Glutamate-based therapeutic approaches: ampakines

2005 • 152 citations

Anesthetic Potency and Influence of Morphine and Sevoflurane on Respiration in μ-Opioid Receptor Knockout Mice

2001 • 139 citations

Naloxone–For Intoxications with Intravenous Heroin and Heroin Mixtures-Harmless or Hazardous? A Prospective Clinical Study

1996 • 138 citations

Postoperative analgesia and vomiting, with special reference to day-case surgery: a systematic review.

1998 • 133 citations

The safety and utilization of patient-controlled analgesia

1997 • 129 citations

cAMP‐dependent reversal of opioid‐ and prostaglandin‐mediated depression of the isolated respiratory network in newborn rats

1997 • 127 citations

Naloxone Reversal of Buprenorphine-induced Respiratory Depression

2006 • 126 citations

POSTOPERATIVE HYPOXAEMIA: COMPARISON OF EXTRADURAL, I.M. AND PATIENT-CONTROLLED OPIOID ANALGESIA

1990 • 126 citations

Ueber das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums

1817 • 125 citations

Influence of anaesthesia and analgesia on the control of breathing

2003 • 120 citations

Blockade of synaptic inhibition within the pre‐Bötzinger complex in the cat suppresses respiratory rhythm generation in vivo

1998 • 116 citations

A Dose-Response Study of Intrathecal Morphine: Efficacy, Duration, Optimal Dose, and Side Effects

1988 • 113 citations

Ampakine CX717 Protects against Fentanyl-induced Respiratory Depression and Lethal Apnea in Rats

2009 • 113 citations

Naloxone reversal of buprenorphine-induced respiratory depression

1989 • 107 citations

Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action

2002 • 104 citations

Ampakines Alleviate Respiratory Depression in Rats

2006 • 103 citations

Ventricular Irritability Associated with the Use of Naloxone Hydrochloride: Two Case Reports and Laboratory Assessment of the Effect of the Drug on Cardiac Excitability

1974 • 99 citations

5‐HT‐1A receptor‐mediated modulation of medullary expiratory neurones in the cat.

1994 • 99 citations

Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and μ-opioid receptor deficient mice

2003 • 95 citations

Hypertensive Reaction to Naloxone

1974 • 86 citations

Efficacy and respiratory effects of low-dose spinal morphine for postoperative analgesia following knee arthroplasty

2000 • 86 citations

A survey of complications documented in a quality-control analysis of patient-controlled analgesia in the postoperative patient

1992 • 83 citations

Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.

2000 • 83 citations

Pulmonary Edema Following Naloxone Administration in a Patient Without Heart Disease

1983 • 81 citations

Fatal Respiratory Depression after??Multiple Intravenous Morphine Injections

2006 • 80 citations

Mu Opioid Receptor Antagonists: Recent Developments

2007 • 79 citations

Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist

1997 • 79 citations

Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus

2004 • 77 citations

Antagonism by naloxone of narcotic-induced respiratory depression and analgesia.

1978 • 77 citations

Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons

1997 • 74 citations

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modelling of the Reversal of Buprenorphine-Induced Respiratory Depression by Naloxone

2007 • 74 citations

A Model of the Ventilatory Depressant Potency of Remifentanil in the Non–steady State

2003 • 72 citations

Naloxone for antagonism of morphine-induced respiratory depression.

1973 • 71 citations

Influences of Morphine on the Ventilatory Response to Isocapnic Hypoxia

1997 • 70 citations

Randomized, Double-blind Study of the Analgesic Efficacy of Morphine-6-Glucuronide versus Morphine Sulfate for Postoperative Pain in Major Surgery

2005 • 69 citations

Mechanism and impact of allosteric AMPA receptor modulation by the AmpakineTM CX546

2001 • 68 citations

[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists

2005 • 63 citations

Serotonin 1A Receptor Agonists Reverse Respiratory Abnormalities in Spinal Cord-Injured Rats

2003 • 61 citations

The Partial 5-Hydroxytryptamine1A Receptor Agonist Buspirone does not Antagonize Morphine-induced Respiratory Depression in Humans

2006 • 58 citations

Naloxone-induced and spontaneous reversal of depressed ventilatory responses to hypoxia during and after continuous infusion of remifentanil or alfentanil.

1995 • 55 citations

Intrathecal morphine for the relief of post‐hysterectomy pain ‐ a double‐blind, dose‐response study

1993 • 53 citations

An acute pain service in an Australian teaching hospital: the first year

1990 • 52 citations

Early Respiratory Depression Resistant to Naloxone Following Epidural Buprenorphine

1986 • 52 citations

The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression

2005 • 51 citations

HYPOXAEMIA AND PAIN RELIEF AFTER LOWER ABDOMINAL SURGERY: COMPARISON OF EXTRADURAL AND PATIENT-CONTROLLED ANALGESIA

1992 • 51 citations

HYPOXAEMIA AND PAIN RELIEF AFTER UPPER ABDOMINAL SURGERY: COMPARISON OF I.M. AND PATIENT-CONTROLLED ANALGESIA

1992 • 48 citations

A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety

2008 • 48 citations

The isolation of morphine--first principles in science and ethics.

2001 • 45 citations

Reversal of Morphine Anesthesia with Naloxone

1974 • 45 citations

Sedation for the critically ill

1999 • 44 citations

Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats

2005 • 43 citations

Buspirone in Rett syndrome respiratory dysfunction

2005 • 41 citations

Buprenorphine-The Unique Opioid Analgesic: Pharmacology and Clinical Application

2007 • 41 citations

Animal-to-Human Extrapolation of the Pharmacokinetic and Pharmacodynamic Properties of Buprenorphine

2007 • 40 citations

Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains

2008 • 37 citations

The Counteraction of Opioid-Induced Ventilatory Depression by the Serotonin 1A-Agonist 8-OH-DPAT Does Not Antagonize Antinociception in Rats In Situ and In Vivo

2009 • 37 citations

Air Pollution Distribution Patterns in the San Bernardino Mountains of Southern California: a 40-Year Perspective

2007 • 33 citations

Metabolism and pharmacokinetics of naloxone.

1973 • 30 citations

Naloxone Reversal of Opioid-Induced Respiratory Depression with Special Emphasis on the Partial Agonist/Antagonist Buprenorphine

2007 • 29 citations

Morphine overdose from error propagation on an acute pain service

2006 • 28 citations

Buspirone treatment for apneustic breathing in brain stem infarct.

2003 • 28 citations

Naloxone reversal of opioid anesthesia revisited: clinical evaluation and plasma concentration analysis of continuous naloxone infusion after anesthesia with high-dose fentanyl

2004 • 26 citations

Ampakine™ CX546 bolsters energetic response of astrocytes: a novel target for cognitive‐enhancing drugs acting as α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor modulators

2005 • 25 citations

Comparison of Remifentanil and Fentanyl for Postoperative Pain Control after Abdominal Hysterectomy

2008 • 25 citations

5-Hydroxytryptamine 1A/7 and 4α Receptors Differentially Prevent Opioid-Induced Inhibition of Brain Stem Cardiorespiratory Function

2007 • 24 citations

Partial versus full agonists for opioid-mediated analgesia--focus on fentanyl and buprenorphine.

2002 • 24 citations

Potency, duration of action and pA2 in man of intravenous naloxone measured by reversal of morphine-depressed respiration.

1981 • 24 citations

Role of Brainstem Sodium/Proton Exchanger 3 for Breathing Control during Chronic Acid–Base Imbalance

2007 • 22 citations

Developmental changes of serotonin 4(a) receptor expression in the rat pre‐Bötzinger complex

2007 • 22 citations

COMPARISON BETWEEN HIGH-DOSE SUFENTANIL-OXYGEN AND HIGH-DOSE FENTANYL-OXYGEN FOR NEUROANAESTHESIA

1985 • 21 citations

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.

2007 • 16 citations

1 Basic Pharmacology of Buprenorphine

2005 • 15 citations

The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat.

2008 • 14 citations

MEDIASTINAL PARATHYROID ADENOMA

1950 • 14 citations