Randomized, Double-blind Study of the Analgesic Efficacy of Morphine-6-Glucuronide versus Morphine Sulfate for Postoperative Pain in Major Surgery

What decline in pain intensity is meaningful to patients with acute pain?

2003 • 482 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Relationships between Measurement of Pain Using Visual Analog Score and Morphine Requirements during Postoperative Intravenous Morphine Titration

2003 • 233 citations

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

2003 • 222 citations

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity

1991 • 211 citations

Pharmacokinetic-Pharmacodynamic Modeling of Morphine-6-glucuronide-induced Analgesia in Healthy Volunteers

2003 • 142 citations

Relationships Among Morphine Metabolism, Pain and Side Effects During Long-Term Treatment

2003 • 141 citations

Biochemical basis for analgesic activity of morphine-6-glucuronide—I

1973 • 135 citations

Evidence for an active transport of morphine‐6‐β‐<scp>d</scp>‐glucuronide but not P‐glycoprotein‐mediated at the blood–brain barrier

2003 • 121 citations

ANALGESIC EFFICACY AND CSF PHARMACOKINETICS OF INTRATHECAL MORPHINE-6-GLUCURONIDE: COMPARISON WITH MORPHINE

1990 • 119 citations

Blood‐brain barrier transport and brain distribution of morphine‐6‐glucuronide in relation to the antinociceptive effect in rats – pharmacokinetic/pharmacodynamic modelling

2001 • 103 citations

Differential blockade of morphine and morphine-6β-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein α subunits in rats

1995 • 98 citations

Serum morphine levels

1984 • 97 citations

Pharmacodynamic Effect of Morphine-6-glucuronide versus Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers

2003 • 91 citations

Elevated concentrations of morphine 6‐beta‐<scp>D</scp>‐glucuronide in brain extracellular fluid despite low blood–brain barrier permeability

1999 • 86 citations

Comparison between patient-controlled analgesia and subcutaneous morphine in elderly patients after total hip replacement †

2003 • 78 citations

DISPOSITION OF MORPHINE-6-GLUCURONIDE AND MORPHINE IN HEALTHY VOLUNTEERS

1991 • 72 citations

Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers

1997 • 72 citations

Morphine-6-glucuronide: effects on ventilation in normal volunteers

1991 • 66 citations

Increased CNS uptake and enhanced antinociception of morphine‐6‐glucuronide in rats after inhibition of P‐glycoprotein

2002 • 64 citations

Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration?

2002 • 60 citations

Pain and the blood–brain barrier: obstacles to drug delivery

2003 • 58 citations

Unwanted effects of morphine‐6‐glucuronide and morphine

2002 • 55 citations

A Comparison of Intrathecal Morphine-6-Glucuronide and Intrathecal Morphine Sulfate as Analgesics for Total Hip Replacement

1996 • 53 citations

Nurse-Administered Subcutaneous Morphine Is a Satisfactory Alternative to Intravenous Patient-Controlled Analgesia Morphine After Cardiac Surgery

1998 • 50 citations

Morphine-6β-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies11Abbreviations: M3G, morphine-3-glucuronide; M6G, morphine-6β-glucuronide; MOR, μ-opioid receptor; KOR, κ-opioid receptor; DOR, δ-opioid receptor; GIRK channel, G-protein coupled inwardly rectifying K+ channel; RGS, regulator of G-protein signaling; GAP, GTPase-activating protein; TM, transmembrane domain, and HK, high potassium.

2001 • 47 citations

Morphine-6-O-?-D-glucuronide but not morphine-3-O-?-D-glucuronide binds to ?-, ?- and ?- specific opioid binding sites in cerebral membranes

1996 • 47 citations

Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula

1997 • 25 citations

Potency ratios of morphine and morphine-6β-glucuronide analgesia elicited from the periaqueductal gray, locus coeruleus or rostral ventromedial medulla of rats

1998 • 15 citations

Effects of morphine glucuronides on the function of opioid receptors in human SK-N-SH cells

2000 • 12 citations