Molecular mechanisms of opioid receptor signal transduction

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Opioid analgesics and antagonists

1996 • 1,193 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin

1982 • 928 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1982 • 777 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Morphine receptors as regulators of adenylate cyclase activity.

1975 • 529 citations

C fragment of lipotropin has a high affinity for brain opiate receptors

1976 • 488 citations

Dimerization of the δ Opioid Receptor:

1997 • 479 citations

A brief history of opiates, opioid peptides, and opioid receptors.

1993 • 469 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

1981 • 390 citations

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

1996 • 327 citations

Immunologic Dysfunction in Heroin Addicts

1974 • 301 citations

Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells

1995 • 291 citations

Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.

1996 • 272 citations

Molecular Characterization of Opioid Receptors

1990 • 266 citations

Opioid receptor types and membrane ion channels

1986 • 248 citations

Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.

1981 • 234 citations

Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.

1988 • 228 citations

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1995 • 222 citations

Interaction of ligands with the opiate receptors of brain membranes: Regulation by ions and nucleotides

1978 • 216 citations

Differential Regulation by Guanine Nucleotides of Opiate Agonist and Antagonist Receptor Interactions

1980 • 201 citations

Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.

1979 • 200 citations

Sequestration of the δ Opioid Receptor

1996 • 198 citations

Effects of opioids on the immune system

1996 • 189 citations

ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.

1984 • 189 citations

δ-Opioid receptor subtypes and cross-talk with μ-receptors

1993 • 188 citations

Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture

1978 • 163 citations

Role of Aromatic Transmembrane Residues of the δ-Opioid Receptor in Ligand Recognition

1996 • 154 citations

A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 • 146 citations

Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat

1994 • 140 citations

mu-Opioid receptor activation reduces multiple components of high- threshold calcium current in rat sensory neurons

1995 • 123 citations

Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits.

1996 • 115 citations

Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.

1993 • 115 citations

Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes.

1995 • 110 citations

Opioid receptors and endogenous opioid peptides

1991 • 107 citations

Morphine alters preproenkephalin gene expression

1988 • 106 citations

Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.

1994 • 105 citations

Thr353, Located within the COOH-terminal Tail of the ´ Opiate Receptor, Is Involved in Receptor Down-regulation

1996 • 105 citations

κ-Opioid Receptor Activation Modulates Ca²⁺Currents and Secretion in Isolated Neuroendocrine Nerve Terminals

1997 • 100 citations

Involvement of Trp-284, Val-296, and Val-297 of the Human δ-Opioid Receptor in Binding of δ-Selective Ligands

1996 • 100 citations

A Chimeric Study of the Molecular Basis of Affinity and Selectivity of the κ and the δ Opioid Receptors.

1995 • 98 citations

The stimulatory effects of opioids and their possible role in the development of tolerance

1996 • 98 citations

Opiate binding to membrane preparations of neuroblastoma X glioma hybrid cells NG108-15: Effects of ions and nucleotides

1978 • 97 citations

Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.

1995 • 90 citations

Fast, local signal transduction between the mu opioid receptor and Ca2+ channels

1995 • 88 citations

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

1994 • 87 citations

Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.

1995 • 85 citations

Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density.

1994 • 81 citations

Opioid receptors from a lower vertebrate ( Catostomus commersoni ): Sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution

1997 • 80 citations

The μ-Opioid Receptor Down-Regulates Differently from the δ-Opioid Receptor: Requirement of a High Affinity Receptor/G Protein Complex Formation

1997 • 72 citations

A Constitutively Internalizing and Recycling Mutant of the μ‐Opioid Receptor

1997 • 68 citations

Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.

1994 • 68 citations

Characterization of an endogenous morphine-like factor(enkephalin) in mammalian brain.

1976 • 67 citations

GTPase and adenylate cyclase desensitize at different rates in NG108-15 cells.

1987 • 66 citations

The Spinal Actions of Opioids

1993 • 66 citations

Inhibitor of cyclic AMP-dependent protein kinase blocks opioid-induced prolongation of the action potential of mouse sensory ganglion neurons in dissociated cell cultures

1988 • 64 citations

Subtypes of the κ-opioid receptor: fact or fiction?

1989 • 62 citations

Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.

1996 • 62 citations

Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover

1994 • 61 citations

Properties of a κ-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual Gα subunit and is similar to that of other opioid receptors

1995 • 61 citations

Differential Agonist Regulation of the Human κ‐Opioid Receptor

1997 • 55 citations

Molecular Mechanisms of Opiate Receptor Coupling to G Proteins and Effector Systems^a

1996 • 55 citations

Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?

1994 • 54 citations

Mu and delta opioid receptor gene expression after chronic treatment with opioid agonist

1996 • 53 citations

Increased biological activity of dimers of oxymorphone and enkephalin: Possible role of receptor crosslinking

1982 • 52 citations

DAMGO, a μ‐opioid receptor selective ligand, distinguishes between μ‐and κ‐opioid receptors at a different region from that for the distinction between μ‐ and δ‐opioid receptors

1995 • 51 citations

Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.

1985 • 51 citations

Opioids at low concentration decrease openings of K+ channels in sensory ganglion neurons

1991 • 49 citations

Dynorphin A-Mediated Reduction in Multiple Calcium Currents Involves a G_oα-Subtype G Protein in Rat Primary Afferent Neurons

1997 • 47 citations

The role of G-protein βγsubunits in signal transduction

1995 • 47 citations

κ-opioid receptor stimulation increases intracellular free calcium in isolated rat ventricular myocytes

1992 • 45 citations

GX/Z Is Regulated by μ But Not δ Opioid Receptors in the Stimulation of the Low K_m GTPase Activity in Mouse Periaqueductal Grey Matter

1997 • 45 citations

κ‐Opioid receptor‐transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments

1995 • 44 citations

Phosphorylated μ-opioid receptor purified from rat brains lacks functional coupling with Gi1, a GTP-binding protein in reconstituted lipid vesicles

1990 • 43 citations

Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of Gi2 and G(x/z) transducer proteins in mouse periaqueductal gray matter.

1997 • 43 citations

Functional analysis of cloned opioid receptors in transfected cell lines

1996 • 43 citations

Kappa opioid receptors stimulate phosphoinositide turnover in rat brain

1990 • 42 citations

Downregulation of mu-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment.

1996 • 39 citations

Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.

1981 • 39 citations

Recent Developments in the Research of Opioid Receptor Subtype Molecular Characterization

1990 • 39 citations

Changes in the association of G protein subunits with the cloned mouse delta opioid receptor on agonist stimulation.

1997 • 39 citations

The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.

1996 • 38 citations

Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.

1996 • 37 citations

Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.

1987 • 36 citations

A single residue, Lys108, of the delta-opioid receptor prevents the mu-opioid-selective ligand [D-Ala2,N-MePhe4,Gly-ol5]enkephalin from binding to the delta-opioid receptor.

1996 • 36 citations

Opiates Stimulate Low K_m GTPase in Brain

1984 • 29 citations

Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.

1995 • 29 citations

Mitogenic signalling by δ opioid receptors expressed in Rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase

1997 • 28 citations

κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

1990 • 27 citations

The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.

1995 • 26 citations

Opioid Peptides and Protein Phosphorylation

1979 • 24 citations

Agonist regulation of the expression of the delta opioid receptor in NG108‐15 cells

1995 • 20 citations

Opioid peptides in the pituitary: a hormone, a paracrine modulator and a peptide in search of a function.

1994 • 10 citations

Changes in opioid receptor density on murine splenocytes induced by in vivo treatment with morphine and methadone.

1996 • 10 citations

Morphine enhances the phosphorylation of a 58 kDa protein in mouse brain membranes

1989 • 9 citations

Long-term regulation of opioid receptors in neuroblastoma and lymphoma cell lines

1997 • 7 citations

Brain slices in radioligand binding assays: Quantification of opiate, benzodiazepines and beta-adrenergic ([3H] CGP-12177) receptors

1984 • 3 citations

Deleted Work

1955 • 0 citations