Construction and Characterization of Herpes Simplex Virus Type 1 Mutants with Defined Lesions in Immediate Early Gene 1

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Herpes simplex virus type 1 ICP27 is an essential regulatory protein

1985 • 462 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

An Improved Technique for Obtaining Enhanced Infectivity with Herpes Simplex Virus Type 1 DNA

1976 • 304 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Physical mapping of herpes simplex virus-induced polypeptides

1978 • 248 citations

Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

1985 • 242 citations

Physical characterization of the herpes simplex virus latency-associated transcript in neurons

1988 • 234 citations

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1

1986 • 192 citations

The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans

1986 • 163 citations

Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides

1978 • 157 citations

Analysis of the functional domains of herpes simplex virus type 1 immediate-early polypeptide Vmw110

1988 • 139 citations

A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1.

1987 • 135 citations

The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products (review).

1987 • 102 citations

Herpes Simplex Virus Genes Involved in Latency in vitro

1987 • 78 citations

Complementation of a Herpes Simplex Virus Type 1 Vmw110 Deletion Mutant by Human Cytomegalovirus

1989 • 49 citations

Promoter sequence and cell type can dramatically affect the efficiency of transcriptional activation induced by herpes simplex virus type 1 and its immediate-early gene products Vmw175 and Vmw110

1988 • 39 citations