Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

2003 • 1,750 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Role of P-Glycoprotein in Pharmacokinetics

2003 • 897 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

2000 • 587 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

2001 • 438 citations

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes

2002 • 438 citations

The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

2003 • 424 citations

Drugs as P-glycoprotein substrates, inhibitors, and inducers

2002 • 364 citations

Clinically Significant Pharmacokinetic Drug Interactions with Carbamazepine

1996 • 327 citations

Human Organic Anion Transporting Polypeptide-C (SLC21A6) Is a Major Determinant of Rifampin-Mediated Pregnane X Receptor Activation

2003 • 325 citations

Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays.

2001 • 289 citations

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction

2000 • 281 citations

The Effect of Rifampin Treatment on Intestinal Expression of Human MRP Transporters

2000 • 278 citations

Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition

2002 • 240 citations

Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

2002 • 219 citations

Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats

2002 • 211 citations

Clinical Pharmacokinetics of the Antituberculosis Drugs

1984 • 206 citations

The effects of the human MDR1 genotype on the expression of duodenal P‐glycoprotein and disposition of the probe drug talinolol

2002 • 201 citations

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

2001 • 201 citations

P‐glycoprotein‐mediated intestinal and biliary digoxin transport in humans

2003 • 156 citations

Carbamazepine is not a substrate for P‐glycoprotein

2001 • 142 citations

Interaction of Antiepileptic Drugs with Human P-Glycoprotein in Vitro

2003 • 128 citations

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects

2004 • 128 citations

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil*

1999 • 95 citations

Multicentre evaluation of an enzymatic method for creatinine determination using a sensitive colour reagent.

1986 • 74 citations

Brain Access and Anticonvulsant Efficacy of Carbamazepine, Lamotrigine, and Felbamate in ABCC2/MRP2‐Deficient TR⁻ Rats

2003 • 62 citations

Unexpected effect of verapamil on oral bioavailability of the β-blocker talinolol in humans

1999 • 58 citations

Induction of CYP3As in HepG2 Cells by Several Drugs. Association between Induction of CYP3A4 and Expression of Glucocorticoid Receptor.

2003 • 57 citations

Effect of levothyroxine administration on intestinal P‐glycoprotein expression: Consequences for drug disposition*

2002 • 47 citations

Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment.

2002 • 7 citations

Asterixis associated with carbamazepine.

1983 • 5 citations