Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5‐ethyl‐5‐phenylhydantoin in the male rat liver or in cultured rat hepatocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Understanding the Dose-Effect Relationship

1981 • 1,111 citations

Principles of Medicinal Chemistry

1975 • 718 citations

Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

1985 • 653 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1988 • 470 citations

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase

1979 • 317 citations

The Regulation of Cytochrome P-450 Gene Expression

1986 • 283 citations

Optical Isomerism and Pharmacological Action, a Generalization

1956 • 194 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates

1975 • 151 citations

Influence of Extracellular Matrix Overlay on Phenobarbital-Mediated Induction of CYP2B1, 2B2, and 3A1 Genes in Primary Adult Rat Hepatocyte Culture

1993 • 140 citations

Receptor-mediated mechanisms of peroxisome proliferators

1992 • 114 citations

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.

1980 • 100 citations

Relationships Between Stereostructure and Pharmacological Activities

1970 • 91 citations

Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1.

1990 • 89 citations

Chiral effects in the induction of drug-metabolizing enzymes using synthetic atropisomers of polychlorinated biphenyls (PCBs)

1989 • 89 citations

Monoclonal antibodies distinguish among isozymes of the cytochrome P-450b subfamily

1985 • 70 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.

1988 • 58 citations

Structural Specificity of Barbiturates and Related Drugs

1982 • 55 citations

Induction by barbiturates of a cytochrome P-450-dependent fatty acid monooxygenase in Bacillus Megaterium: Relationship between barbiturate structure and inducer activity

1983 • 52 citations

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

1990 • 52 citations

A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin).

1954 • 27 citations

Metabolic demethylation of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin).

1952 • 24 citations

OPTICALLY ACTIVE 5,5'-DISUBSTITUTED HYDANTOINS¹

1932 • 22 citations

Acylureas: A new class of barbiturate-like bacterial cytochrome P-450 inducers

1984 • 21 citations

Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes

1993 • 20 citations

Co-induction of cytochrome P4504A1 and peroxisome proliferation: A causal or casual relationship?

1992 • 19 citations

Mechanisms of phenobarbital-type induction of cytochrome P-450 isozymes

1987 • 18 citations

Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog.

1977 • 15 citations

Stereospecific induction of rat liver bilirubin UDPglucuronosyltransferase and lauric acid 12-hydroxylation by the isomers of 2-phenylpropionic acid

1986 • 13 citations

Pharmacodynamics of cytochrome P450 2B induction by phenobarbital, 5-ethyl-5-phenylhydantoin, and 5-ethyl-5-phenyloxazolidinedione in the male rat liver or in cultured rat hepatocytes

1993 • 11 citations

Hepatic cytochrome P450 2B-type induction by ethyl/phenyl-substituted congeners of phenobarbital in the rat

1993 • 10 citations

Differential induction of cytochrome P-450 by the enantiomers of trans-stilbene oxide

1987 • 9 citations

CHEMICAL ALLERGY AND NIRVANOL SICKNESS

1933 • 9 citations

Induction of drug-metabolizing enzymes by the enantiomers of normephenytoin in the rat.

1981 • 9 citations

Pharmacological study of dextrorotatory and levorotatory pheneturide.

1959 • 3 citations