Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Hypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System

1996 • 1,453 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

1994 • 683 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Body Fat and the Activity of the Autonomic Nervous System

1988 • 420 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans.

1993 • 324 citations

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

1997 • 286 citations

Pancreatic β-Cells in Obesity

1995 • 276 citations

Relation of obesity and diet to sympathetic nervous system activity.

1991 • 267 citations

Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion

1986 • 265 citations

Effects of a 48-h Fat Infusion on Insulin Secretion and Glucose Utilization

1995 • 258 citations

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

1998 • 256 citations

Mechanisms of the Stimulation of Insulin Release by Saturated Fatty Acids: A Study of Palmitate Effects in Mouse β-cells

1994 • 204 citations

High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat

1996 • 181 citations

Arterial alpha-adrenergic responsiveness is decreased and SNS activity is increased in older humans

1994 • 150 citations

Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1

1997 • 142 citations

Induction by Glucose of Genes Coding for Glycolytic Enzymes in a Pancreatic β-Cell Line (INS-1)

1997 • 135 citations

Relationship between sympathetic activity and diet-induced obesity in two rat strains

1983 • 121 citations

Fatty acids in the portal vein of the rat regulate hepatic insulin clearance.

1991 • 121 citations

Palmitate-Induced β-Cell Insensitivity to Glucose is Coupled to Decreased Pyruvate Dehydrogenase Activity and Enhanced Kinase Activity in Rat Pancreatic Islets

1995 • 89 citations

Impaired β-Cell Function and Deposition of Fat Droplets in the Pancreas as a Consequence of Hypertriglyceridemia in OLETF Rat, a Model of Spontaneous NIDDM

1997 • 73 citations

Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)

1997 • 72 citations

Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys

1990 • 67 citations

Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids

1997 • 64 citations

Metabolic and Neurologic Effects of an Intravenous Medium‐Chain Triglyceride Emulsion

1991 • 57 citations

[DIABETES IN ANIMALS].

1964 • 52 citations

Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia.

1990 • 52 citations

Differential effects of dietary fats on sympathetic nervous system activity in the rat

1994 • 50 citations

Hyperglycaemia induced by glucose infusion in the unrestrained pregnant rat during the last three days of gestation: Metabolic and hormonal changes in the mother and the fetuses

1981 • 41 citations

Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta cell in rats.

1994 • 40 citations

Body fat and sympathetic nerve activity

1996 • 37 citations

Canine myocardial beta-adrenergic, muscarinic receptor densities after denervation: a PET study.

1995 • 35 citations

Comparison of dna contents of visceral organs in rats with ventromedial hypothalamic lesions and fed a high fat diet

1991 • 24 citations

The characteristics of β-adrenergic binding sites on pancreatic islets of Langerhans

1986 • 23 citations

Up-regulation ofβ-adrenoceptors on circulating mononuclear cells after reduction of central sympathetic outflow by clonidine in normal subjects

1992 • 20 citations

In vivo insulin secretion and action in hyperglycemic rat

1989 • 18 citations

Regulation of venous alpha-adrenergic responses in older humans

1991 • 14 citations

The determination of alpha-adrenergic receptor concentration on rat pancreatic islet cells

1987 • 12 citations