Nitric Oxide–Induced Apoptosis in Lymphoblastoid and Fibroblast Cells Dependent on the Phosphorylation and Activation of p53

The biochemistry of apoptosis

2000 • 7,314 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Radical causes of cancer

2003 • 1,611 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

2003 • 788 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects

1997 • 433 citations

Nitric Oxide Inhibits Caspase-3 by S-Nitrosationin Vivo

1999 • 427 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation

2001 • 375 citations

S-Nitrosylation of mitochondrial caspases

2001 • 365 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

2002 • 346 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Inhibition of Mitochondrial ATP Generation by Nitric Oxide Switches Apoptosis to Necrosis

1999 • 273 citations

DNA Damage by Nitric Oxide

1996 • 248 citations

Regulation of the apoptosis–necrosis switch

2004 • 235 citations

Nitric Oxide-induced Deamination of Cytosine and Guanine in Deoxynucleosides and Oligonucleotides

1998 • 176 citations

p38 Kinase Regulates Nitric Oxide-induced Apoptosis of Articular Chondrocytes by Accumulating p53 via NFκB-dependent Transcription and Stabilization by Serine 15 Phosphorylation

2002 • 171 citations

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

2004 • 151 citations

A Chemical Perspective on the Interplay Between NO, Reactive Oxygen Species, and Reactive Nitrogen Oxide Species

2002 • 146 citations

Absence of Radiation-induced G1 Arrest in Two Closely Related Human Lymphoblast Cell Lines That Differ in p53 Status

1995 • 136 citations

Diazeniumdiolates:

2000 • 126 citations

Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion

1995 • 126 citations

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation

2003 • 103 citations

Role of Mitogen-Activated Protein Kinases inS-Nitrosoglutathione-Induced Macrophage Apoptosis

1999 • 99 citations

A Mechanistic Analysis of Nitric Oxide-Induced Cellular Toxicity

1997 • 90 citations

U937 Apoptotic Cell Death by Nitric Oxide: Bcl-2 Downregulation and Caspase Activation

1998 • 88 citations

Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53

2002 • 78 citations

Nitric oxide induces phosphorylation of p53 and impairs nuclear export

2003 • 77 citations

Apoptotic Signaling Pathways Induced by Nitric Oxide in Human Lymphoblastoid Cells Expressing Wild-Type or Mutant p53

2004 • 74 citations

Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

1997 • 74 citations

p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide

1999 • 66 citations

Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest

2000 • 64 citations

Genotoxicity, Mitochondrial Damage, and Apoptosis in Human Lymphoblastoid Cells Exposed to Peroxynitrite Generated from SIN-1

2002 • 55 citations

Hepatocellular oxidative DNA injury induced by macrophage-derived nitric oxide

2001 • 51 citations

Nitric oxide‐induced cell death of cerebrocortical murine astrocytes is mediated through p53‐ and Bax‐dependent pathways

2004 • 49 citations

Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism

2001 • 33 citations

Isolation of Intact Organelles by Differential Centrifugation of Digitonin-Treated Hepatocytes Using a Table Eppendorf Centrifuge

1998 • 29 citations

Potentiation of nitric oxide-induced apoptosis in p53^−/− vascular smooth muscle cells

2002 • 25 citations