p38 Kinase Regulates Nitric Oxide-induced Apoptosis of Articular Chondrocytes by Accumulating p53 via NFκB-dependent Transcription and Stabilization by Serine 15 Phosphorylation

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis

2001 • 841 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

Regulation and function of the p53 tumor suppressor protein

2001 • 716 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

1998 • 581 citations

Regulation of the p53 Tumor Suppressor Protein

1999 • 566 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis

1998 • 498 citations

NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

1998 • 454 citations

The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

1999 • 444 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation

2000 • 347 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-κB Transcriptional Activation and Cytokine Secretion

2001 • 327 citations

Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin

2000 • 280 citations

A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.

2000 • 264 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

ERK-1/2 and p38 Kinase Oppositely Regulate Nitric Oxide-induced Apoptosis of Chondrocytes in Association with p53, Caspase-3, and Differentiation Status

2002 • 242 citations

Cytokines and their role in the pathophysiology of osteoarthritis

1999 • 238 citations

The role of nitric oxide in articular cartilage breakdown in osteoarthritis

1998 • 220 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria

2000 • 191 citations

The Genomic Response of Tumor Cells to Hypoxia and Reoxygenation

1995 • 178 citations

Maintenance of Differentiated Phenotype of Articular Chondrocytes by Protein Kinase C and Extracellular Signal-regulated Protein Kinase

2002 • 162 citations

p38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells

2001 • 152 citations

Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines

2001 • 122 citations

Degradation and repair of articular cartilage

1999 • 122 citations

Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.

2001 • 96 citations

Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway

2001 • 92 citations

Mechanism of p53-dependent Apoptosis Induced by 3-Methylcholanthrene

2002 • 85 citations

p53 Activation by Nitric Oxide Involves Down-regulation of Mdm2

2002 • 85 citations

Linkage of the BH4 Domain of Bcl-2 and the Nuclear Factor κB Signaling Pathway for Suppression of Apoptosis

1999 • 83 citations

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

1999 • 78 citations

Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc

2000 • 76 citations

Nitric Oxide–Dependent Activation of P53 Suppresses Bleomycin-Induced Apoptosis in the Lung

2000 • 75 citations

Transcription factors p53 and HIF-1α as targets of nitric oxide

2001 • 68 citations

Transcription activator protein 1 (AP‐1) mediates NO‐induced apoptosis of adult cardiomyocytes

2001 • 66 citations

Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest

2000 • 64 citations

Inhibition of Cell Cycle Progression by the Novel Cyclophilin Ligand Sanglifehrin A Is Mediated through the NFκB-dependent Activation of p53

2001 • 57 citations

Potentiation of nitric oxide-induced apoptosis in p53^−/− vascular smooth muscle cells

2002 • 25 citations

Polymerase chain reaction (current communications in molecular biology)

1990 • 22 citations