How Obesity Causes Diabetes: Not a Tall Tale

Translating the Histone Code

2001 • 9,488 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

2003 • 5,872 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

Adipose Tissue as an Endocrine Organ

2004 • 5,220 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Economic Costs of Diabetes in the U.S. in 2002

2003 • 4,253 citations

Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

1999 • 3,707 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

1992 • 3,255 citations

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

1999 • 2,323 citations

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

2004 • 1,897 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Lifetime Risk for Diabetes Mellitus in the United States

2003 • 1,545 citations

The Sir2 Family of Protein Deacetylases

2004 • 1,478 citations

Menstrual Cycles: Fatness as a Determinant of Minimum Weight for Height Necessary for Their Maintenance or Onset

1974 • 1,421 citations

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

2002 • 1,264 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

2003 • 1,192 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Resistin is expressed in human macrophages and directly regulated by PPARγ activators

2003 • 898 citations

Type 2 Diabetes-a Matter of ß-Cell Life and Death?

2005 • 881 citations

Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

2004 • 877 citations

Inflammatory pathways and insulin action

2003 • 716 citations

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

2000 • 623 citations

PPARγ, the ultimate thrifty gene

1999 • 609 citations

Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

2003 • 587 citations

The Function of Leptin in Nutrition, Weight, and Physiology

2002 • 512 citations

The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X

2003 • 482 citations

The double puzzle of diabetes

2003 • 481 citations

Peroxisome proliferator-activated receptor γ in diabetes and metabolism

2004 • 435 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

Lipid overload and overflow: metabolic trauma and the metabolic syndrome

2003 • 390 citations

Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting

2004 • 343 citations

Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness

1999 • 253 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

The G/G Genotype of a Resistin Single-Nucleotide Polymorphism at −420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing Promoter Activity through Specific Binding of Sp1/3

2004 • 224 citations

Adiponectin and its role in the obesity-induced insulin resistance and related complications.

2004 • 222 citations

Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling

2004 • 217 citations

Insulin Resistance and Substrate Utilization in Human Endotoxemia

2000 • 207 citations

Caloric restriction, body fat and ageing in experimental models

2004 • 120 citations

Genotype, obesity and cardiovascular disease – has technical and social advancement outstripped evolution?

2003 • 93 citations

Subcutaneous Abdominal Adipocyte Size, a Predictor of Type 2 Diabetes, Is Linked to Chromosome 1q21–q23 and Is Associated with a Common Polymorphism in LMNA in Pima Indians

2001 • 74 citations

The genetics of obesity

2003 • 63 citations

A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: the invertebrate phagocytic immunocyte as an eye-witness

1998 • 54 citations

High‐density Lipoproteins: Effects of Alcohol, Estrogen, and Phytoestrogens

2002 • 42 citations

How does blood glucose control with insulin save lives in intensive care?

2004 • 31 citations