Effective Induction of Simian Immunodeficiency Virus-Specific Systemic and Mucosal Immune Responses in Primates by Vaccination with Proviral DNA Producing Intact but Noninfectious Virions

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

2000 • 1,247 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian–human immunodeficiency virus infection

2000 • 861 citations

Improved DNA: liposome complexes for increased systemic delivery and gene expression

1997 • 738 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

1990 • 531 citations

[17]Gene splicing by overlap extension

1993 • 463 citations

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

1998 • 409 citations

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

1999 • 384 citations

The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

1990 • 335 citations

Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus

1998 • 334 citations

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

1996 • 325 citations

Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination

1997 • 314 citations

Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

1999 • 312 citations

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques

1996 • 299 citations

Priming of Cytotoxic T Lymphocytes by DNA Vaccines: Requirement for Professional Antigen Presenting Cells and Evidence for Antigen Transfer from Myocytes

1997 • 296 citations

Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine

1993 • 265 citations

Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells

1991 • 247 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

Highly Attenuated Vaccine Strains of Simian Immunodeficiency Virus Protect against Vaginal Challenge: Inverse Relationship of Degree of Protection with Level of Attenuation

1999 • 218 citations

Plasma SIV RNA Viral Load Determination by Real-Time Quantification of Product Generation in Reverse Transcriptase-Polymerase Chain Reaction

1998 • 205 citations

Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques

1995 • 188 citations

Epidemiologic and Biologic Characterization of a Cohort of Human Immunodeficiency Virus Type 1 Highly Exposed, Persistently Seronegative Female Sex Workers in Northern Thailand

1999 • 179 citations

Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity

1996 • 146 citations

Nasal Immunization of Nonhuman Primates with Simian Immunodeficiency Virus p55gagand Cholera Toxin Adjuvant Induces Th1/Th2 Help for Virus-Specific Immune Responses in Reproductive Tissues

1998 • 143 citations

Induction of Mucosal and Systemic Immunity to a Recombinant Simian Immunodeficiency Viral Protein

1992 • 142 citations

Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus

1997 • 142 citations

Long‐Term Immunity and Protection against Herpes Simplex Virus Type 2 in the Murine Female Genital Tract after Mucosal but Not Systemic Immunization

1998 • 136 citations

An Essential Interaction between Distinct Domains of HIV-1 Integrase Mediates Assembly of the Active Multimer

1995 • 130 citations

Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251

1998 • 126 citations

Mechanism of genital transmission of SIV: A hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques

1992 • 117 citations

Human Immunodeficiency Virus Reverse Transcriptase

1996 • 112 citations

Modified Wick Method Using Weck-Cel Sponges for Collection of Human Rectal Secretions and Analysis of Mucosal HIV Antibody

2000 • 110 citations

Mucosal or targeted lymph node immunization of macaques with a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal mucosa and draining lymph nodes.

1996 • 91 citations

DNA Vaccination Affords Significant Protection against Feline Immunodeficiency Virus Infection without Inducing Detectable Antiviral Antibodies

1998 • 86 citations

Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: what mediates protection and why does it develop?

1999 • 81 citations

Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys.

1996 • 76 citations

Targeted lymph node immunization with simian immunodeficiency virus p27 antigen to elicit genital, rectal, and urinary immune responses in nonhuman primates.

1994 • 75 citations

Modified Wick Method Using Weck-Cel Sponges for Collection of Human Rectal Secretions and Analysis of Mucosal HIV Antibody

2000 • 70 citations

Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging

1998 • 58 citations

Protection from pathogenic SIV challenge using multigenic DNA vaccines

1999 • 52 citations

Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.

1997 • 52 citations

Neutralizing Antibodies in Sera from Macaques Immunized with Attenuated Simian Immunodeficiency Virus

1998 • 48 citations

Beta-chemokine production in macaques vaccinated with live attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge.

1999 • 45 citations

Prolonged Clinical Latency and Survival of Macaques Given a Whole Inactivated Simian Immunodeficiency Virus Vaccine

1994 • 44 citations

Priming with tat -Deleted Caprine Arthritis Encephalitis Virus (CAEV) Proviral DNA or Live Virus Protects Goats from Challenge with Pathogenic CAEV

1998 • 28 citations

A role for mucosal immunity in resistance to HIV infection

1999 • 17 citations

Rapid and Selective Depletion of CD4+ T Lymphocytes and Preferential Loss of Memory Cells on Interaction of Mononuclear Cells With HIV-1 Glycoprotein-Expressing Cells

1997 • 16 citations

Combined Systemic and Mucosal Immunization with Microsphere-Encapsulated Inactivated Simian Immunodeficiency Virus Elicits Serum, Vaginal, and Tracheal Antibody Responses in Female Rhesus Macaques

1999 • 15 citations

Progress towards a vaccine to prevent sexual transmission of HIV

1996 • 14 citations

FUNCTIONAL MUTANTS OBTAINED BY RANDOM MUTAGENESIS COUPLED WITH GENETIC SELECTION IN ESCHERICHIA COLI

1996 • 6 citations

Generation of monoclonal antibodies to Macaca mulatta (rhesus) IgA

1995 • 1 citations