Cells That Overproduce Protein Kinase C Are More Susceptible to Transformation by an Activated H-ras Oncogene

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

1985 • 210 citations

Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies

1987 • 173 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H- ras p21

1987 • 134 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

1987 • 129 citations

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.

1987 • 128 citations

Immunochemical identification of protein kinase C isozymes as products of discrete genes

1987 • 105 citations

Oncogene-Induced Transformation of C3H 10T1/2 Cells Is Enhanced by Tumor Promoters

1984 • 89 citations

Oncogene-Induced Transformation of a Rat Embryo Fibroblast Cell Line is Enhanced by Tumor Promoters

1986 • 46 citations

Phosphorylation of ras oncogene product by protein kinase C

1987 • 45 citations

Inducible gene expression from multiple promoters by the tumor-promoting agent, PMA

1987 • 18 citations