Role of bile acids and neutral sterols in carcinogenesis

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

1974 • 717 citations

Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats2

1976 • 264 citations

Diet and excretion of bile acids.

1981 • 211 citations

Host Factors in Carcinogenesis: Certain Bile-Acid Metabolic Profiles That Selectively Increase the Risk of Proximal Colon Cancer

1985 • 178 citations

Effect of Cholic Acid Feeding on <italic>N</italic>-Methyl-<italic>N</italic>-nitrosourea-Induced Colon Tumors and Cell Kinetics in Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 174 citations

Polyunsaturated fat, cholesterol and large bowel tumorigenesis

1977 • 160 citations

Bile Acids: Co-mutagenic Activity in the Salmonella-Mammalian-Microsome Mutagenicity Test: Brief Communication2

1977 • 160 citations

Production of Tumours in Mice by Deoxycholic Acid

1940 • 144 citations

Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products.

1984 • 123 citations

Cholesterol epoxide is a direct-acting mutagen.

1984 • 112 citations

Acute and Chronic Effect of Dietary Cholic Acid on Colonic Epithelial Cell Proliferation

1981 • 109 citations

Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine.

1982 • 105 citations

Structure elucidation of a potent mutagen from human feces

1982 • 101 citations

Transformation of hamster embryo cells by cholesterol-α-epoxide and lithocholic acid

1979 • 94 citations

Structures of fecapentaenes, the mutagens of bacterial origin isolated from human feces

1983 • 93 citations

Mutagenicity of 1,2-dimethylhydrazine towards Salmonella typhimurium, co-mutagenic effect of secondary biliary acids

1983 • 77 citations

Fecal bile acids in two Japanese populations with different colon cancer risks.

1979 • 74 citations

Activation of carcinogens and mutagens by rat colon mucosa.

1978 • 69 citations

Fecal steroids and colorectal cancer

1987 • 66 citations

Metabolic epidemiology of colon cancer: effect of dietary fiber on fecal mutagens and bile acids in healthy subjects.

1987 • 63 citations

Influence of Bile on Kinetic Behavior of Colonic Epithelial Cells of the Rat

1979 • 61 citations

The mutagenicity of bile acids using a fluctuation test

1985 • 59 citations

Carcinogenic Activity of Apocholic Acid

1961 • 55 citations

Effects of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats.

1986 • 54 citations

Steroids and cancer: Faecal bile acid screening for early detection of cancer risk

1986 • 54 citations

Inhibition of hepatic and extrahepatic glutathione S-transferases by primary and secondary bile acids

1986 • 52 citations

The importance of the ratio of lithocholic to deoxycholic acid in large bowel carcinogenesis

1987 • 52 citations

Production by lithocholic acid of DNA strand breaks in L1210 cells.

1980 • 49 citations

Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis.

1981 • 48 citations

Fecal bile acid excretion pattern in colonic cancer patients

1985 • 46 citations

Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate.

1978 • 45 citations

Bile acid receptors in colorectal cancer

1983 • 44 citations

The conversion of a bile acid into a hydrocarbon derived from 1: 2‐benzanthracene

1933 • 43 citations

Stimulation of mutagen production in human feces by bile and bile acids

1982 • 42 citations

Carcinogenic Activity in situ of Further Steroid Compounds

1966 • 42 citations

Binding of bile acids by glutathione S-transferases from rat liver.

1990 • 41 citations

Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate

1978 • 41 citations

Mitotic aneuploidy as a possible mechanism for tumour promoting activity in bile acids

1984 • 39 citations

The possible carcinogenic effect of cholecystectomy. No postoperative increase in the proportion of secondary bile acids

1983 • 38 citations

Effect of dietary cholesterol on azoxymethane-induced colon carcinogenesis in rats

1983 • 36 citations

Effect of Deoxycholic Acid on the Tumour Incidence, Distribution, and Receptor Status of Colorectal Cancer in the Rat Model

1985 • 35 citations

METHYLCHOLANTHRENE FROM CHOLIC ACID

1935 • 31 citations

EPIDEMIOLOGY OF FECAL MUTAGENICITY1

1986 • 31 citations

Lithocholic acid in human liver: Identification of ∈‐lithocholyl lysine in tissue protein

1977 • 30 citations

Bile acids in tissues: Binding of lithocholic acid to protein

1978 • 29 citations

Faecal bile acids and clostridia in patients with breast cancer

1980 • 26 citations

CARCINOMA OF THE COLON AND CHOLECYSTECTOMY

1974 • 25 citations

Promotive effect of primary and secondary bile acids on the induction of gamma-glutamyl transpeptidase-positive liver cell foci as a possible endogenous factor for hepatocarcinogenesis in rats.

1984 • 24 citations

Tissue bile acids in patients with colon cancer and colonic polyps.

1982 • 22 citations

Mutagenicity testing of steroids obtained from bile acids and cholesterol

1983 • 21 citations

Combined effects of cholecystectomy and lithocholic acid on pancreatic carcinogenesis of N-nitrosobis(2-hydroxypropyl)amine in Syrian golden hamsters.

1986 • 21 citations

Ultrastructural modifications of intestinal and colonic mucosa induced by free or bound bile acids.

1981 • 20 citations

Metabolism of neutral sterols

1984 • 20 citations

Introduction: correlates of diet, nutrient intake, and metabolism in relation to colon cancer

1984 • 18 citations

Role of bile acids and neutral sterols in familial cancer syndromes of the colon

1983 • 17 citations

The effects of cholic acid and bile salt binding agents on 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat

1981 • 14 citations

Fecal Steroids in the Etiology of Large Bowel Cancer

1976 • 12 citations

The correlation between cholecystectomy and fecal bile acids, and large-bowel cancer induced with 1,2-dimethylhydrazine in mice

1985 • 12 citations

Fecal bile acids and neutral sterols in rats with spontaneous colon cancer

1986 • 10 citations

Influence of lithocholic acid on 2-aminoanthracene-induced alterations in DNA synthesis in rat tissues in vivo.

1980 • 6 citations