p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Tau protein function in living cells.

1986 • 727 citations

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

2001 • 685 citations

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

1999 • 548 citations

Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments

1999 • 520 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Evolution of neuronal changes in the course of Alzheimer’s disease

1998 • 481 citations

Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle-Related Events in Alzheimer Disease

2000 • 355 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

1992 • 334 citations

Isolation of Microtubule Protein from Cultured Mouse Neuroblastoma Cells

1970 • 313 citations

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

1999 • 283 citations

Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

1998 • 281 citations

Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys

1973 • 270 citations

Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study.

1970 • 205 citations

Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth

1998 • 193 citations

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3? and cdk5 are key participants

2000 • 173 citations

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.

1994 • 166 citations

Structure of tau protein and assembly into paired helical filaments

2000 • 161 citations

Cyclin' toward dementia

2000 • 158 citations

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

1992 • 157 citations

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease

1999 • 128 citations

A Cdk5–p35 Stable Complex Is Involved in the β-Amyloid-Induced Deregulation of Cdk5 Activity in Hippocampal Neurons

2001 • 125 citations

Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease

1996 • 119 citations

alpha-adrenergic antagonists as possible calcium channel inhibitors.

1981 • 105 citations

Aβ amyloidosis induces the initial stage of tau accumulation in APPSw mice

2001 • 95 citations

Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity

1999 • 92 citations

Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice

2001 • 80 citations

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

2001 • 78 citations

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

2001 • 71 citations

Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10.

1999 • 69 citations

Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

1992 • 62 citations

Changes in serum dopamine-beta-hydroxylase activity during cold pressor test in subjects with high and low basal activity of this enzyme

1982 • 62 citations

Tricresyl phosphate inhibits the formation of axon-like processes and disrupts neurofilaments in cultured mouse N2a and rat PC12 cells

1998 • 56 citations

Ligation of Microglial CD40 Results in p44/42 Mitogen-Activated Protein Kinase-Dependent TNF-α Production That Is Opposed by TGF-β1 and IL-10

1999 • 53 citations

Site‐Specific Dephosphorylation of Tau of Apolipoprotein E‐Deficient and Control Mice by M1 Muscarinic Agonist Treatment

1999 • 48 citations

Tau Protein Is Hyperphosphorylated in a Site‐Specific Manner in Apoptotic Neuronal PC12 Cells

2000 • 47 citations