Pharmacogenetics in Psychiatry: Are We Ready for Widespread Clinical Use?

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

2005 • 5,799 citations

Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis

2005 • 1,283 citations

Interaction between BDNF and Serotonin: Role in Mood Disorders

2007 • 726 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

2004 • 708 citations

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

2004 • 651 citations

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine

1998 • 605 citations

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients

2006 • 527 citations

Variation in the Gene Encoding the Serotonin 2A Receptor Is Associated with Outcome of Antidepressant Treatment

2006 • 472 citations

Predictors of Treatment Response From a First Episode of Schizophrenia or Schizoaffective Disorder

1999 • 462 citations

Association of antipsychotic druginduced weight gain with a 5-HT2C receptor gene polymorphism

2002 • 405 citations

Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome

1994 • 380 citations

Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

2008 • 376 citations

Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis

2007 • 361 citations

Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy

2007 • 358 citations

Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research

2007 • 340 citations

The CYP2D6 Poor Metabolizer Phenotype May Be Associated With Risperidone Adverse Drug Reactions and Discontinuation

2005 • 315 citations

Interaction of COMT Val^108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

2004 • 277 citations

Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

2005 • 266 citations

Metabolic Drug Interactions with Newer Antipsychotics: A Comparative Review

2006 • 254 citations

The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity

2004 • 254 citations

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response

1998 • 254 citations

Smoking in Patients Receiving Psychotropic Medications

2001 • 250 citations

Substance use: a powerful predictor of relapse in schizophrenia

1996 • 244 citations

Pharmacogenetics of Tardive Dyskinesia Combined Analysis of 780 Patients Supports Association with Dopamine D3 Receptor Gene Ser9Gly Polymorphism

2002 • 241 citations

Association Between a Functional Serotonin Transporter Promoter Polymorphism and Citalopram Treatment in Adult Outpatients With Major Depression

2007 • 216 citations

Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia.

1996 • 215 citations

Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571).

2002 • 211 citations

The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment

2002 • 201 citations

Remission in early psychosis: Rates, predictors, and clinical and functional outcome correlates

2006 • 191 citations

Association between clozapine response and allelic variation in the 5-HT2C receptor gene

1995 • 185 citations

Sex, Race, and Smoking Impact Olanzapine Exposure

2008 • 176 citations

Brain Derived Neurotrophic Factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia

2000 • 175 citations

ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder

2007 • 172 citations

The effect of variable cigarette consumption on the interaction with clozapine and olanzapine

2006 • 170 citations

A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia

2000 • 169 citations

Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

2004 • 167 citations

The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement

2003 • 163 citations

Prediction of Antidepressant Response to Milnacipran by Norepinephrine Transporter Gene Polymorphisms

2004 • 159 citations

Ethnicity and Treatment Response in Schizophrenia

2002 • 156 citations

Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

1998 • 155 citations

DRD2 Promoter Region Variation as a Predictor of Sustained Response to Antipsychotic Medication in First-Episode Schizophrenia Patients

2006 • 151 citations

Risperidone-related Weight Gain

2006 • 147 citations

Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions

2008 • 146 citations

Gender Differences in the Prescribing of Antipsychotic Drugs

2006 • 145 citations

Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: A meta analysis

2006 • 142 citations

Association between the serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia: additive contribution of 5-HT2C ser and DRD3 gly alleles to susceptibility

2000 • 139 citations

Association of Short-Term Response to Haloperidol Treatment With a Polymorphism in the Dopamine D₂Receptor Gene

2001 • 138 citations

Association of Risperidone Treatment Response With a Polymorphism in the 5-HT_2A Receptor Gene

2002 • 137 citations

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications

2004 • 133 citations

Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response

2004 • 132 citations

Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia

2003 • 131 citations

Clinical Predictors of Acute Response With Quetiapine in Psychotic Mood Disorders

2000 • 128 citations

Serotonin-6 receptor variant (C267T) and clinical response to clozapine

1999 • 126 citations

The Dosing of Atypical Antipsychotics

2005 • 126 citations

Predictors of Response to Acute Treatment of Chronic and Double Depression With Sertraline or Imipramine

1998 • 124 citations

Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic Pakistani patients

1999 • 121 citations

Nonresponse to Clozapine and Ultrarapid CYP1A2 Activity

2004 • 119 citations

Gender differences in response to antipsychotic treatment in outpatients with schizophrenia

2007 • 116 citations

Psychopharmacology: Atypical Antipsychotic Dosing: The Effect of Smoking and Caffeine

2004 • 115 citations

Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype

2005 • 115 citations

Interaction of COMT Val108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

2004 • 114 citations

AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry

2006 • 108 citations

Predictors of Relapse in a Prospective Study of Fluoxetine Treatment of Major Depression

2006 • 106 citations

Polymorphic Variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and Dopamine D2 and D3 Receptors and Their Association With Tardive Dyskinesia in Severe Mental Illness

2005 • 104 citations

A Study of Genetic (CYP2D6 and ABCB1) and Environmental (Drug Inhibitors and Inducers) Variables That May Influence Plasma Risperidone Levels

2007 • 103 citations

Pathway-based association analysis of genome-wide screening data suggest that genes associated with the γ-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia

2008 • 103 citations

COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia

2006 • 101 citations

Familial occurrence of tardive dyskinesia

2001 • 99 citations

A Novel Single Nucleotide Polymorphism Altering Stability and Activity of CYP2A6

2001 • 99 citations

Pharmacogenomics and antidepressant drugs

2006 • 99 citations

Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function

2004 • 97 citations

Treatment-Resistance to Clozapine in Association With Ultrarapid CYP1A2 Activity and the C → A Polymorphism in Intron 1 of the CYP1A2 Gene: Effect of Grapefruit Juice and Low-Dose Fluvoxamine

2001 • 96 citations

INFLUENCE OF PHARMACOGENETICS ON DRUG DISPOSITION AND RESPONSE

1996 • 94 citations

Attention-Deficit/Hyperactivity Disorder Pharmacogenomics

2005 • 94 citations

Association study of 12 polymorphisms spanning the dopamine D2 receptor gene and clozapine treatment response in two treatment refractory/intolerant populations

2005 • 94 citations

Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine

2000 • 94 citations

The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia

2005 • 93 citations

Ethnicity and Antipsychotic Response

1997 • 90 citations

Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism

2006 • 87 citations

Gender differences in response to antidepressant treatment prescribed in primary care. Does menopause make a difference?

2006 • 87 citations

Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms

2006 • 85 citations

Predictors of acute treatment response in patients with a first episode of non-affective psychosis: Sociodemographics, premorbid and clinical variables

2006 • 85 citations

Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients

2006 • 84 citations

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

2007 • 83 citations

A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders

2007 • 82 citations

Clinical applications of pharmacogenetics in psychiatry

2002 • 81 citations

Polymorphisms of the dopamine D 4 receptor and response to antipsychotic drugs

1999 • 81 citations

C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population

2005 • 80 citations

Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment

2005 • 77 citations

Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia

1998 • 77 citations

Environmental Studies of Schizophrenia Through the Prism of Epigenetics

2008 • 77 citations

Pharmacogenetics in the treatment of depression: pharmacodynamic studies

2005 • 77 citations

Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case–control study

2002 • 75 citations

Weight gain associated with the α_2a‐adrenergic receptor −1291 C/G polymorphism and olanzapine treatment

2006 • 74 citations

Dopamine D3 Receptor Ser9Gly Polymorphism and Risperidone Response

2005 • 74 citations

Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation

2005 • 72 citations

Tumor Necrosis Factor Constellation Polymorphism and Clozapine-Induced Agranulocytosis in Two Different Ethnic Groups

1997 • 72 citations

CYP2D6 polymorphisms and atypical antipsychotic weight gain

2002 • 70 citations

Clinical Predictors of Response to Clozapine Treatment in Ambulatory Patients With Schizophrenia

2002 • 69 citations

Association Analysis of the Dopamine D3 Receptor Gene ser9gly and Brain-Derived Neurotrophic Factor Gene val66met Polymorphisms With Antipsychotic-Induced Persistent Tardive Dyskinesia and Clinical Expression in Chinese Schizophrenic Patients

2004 • 69 citations

Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients

2004 • 67 citations

Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients

2006 • 67 citations

Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders

2003 • 66 citations

HER2/neu as a Predictive Factor in Breast Cancer

2001 • 66 citations

Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens

2006 • 66 citations

Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism

2004 • 65 citations

Predictors of response to lithium augmentation in tricyclic antidepressant-resistant depression

2001 • 65 citations

Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia

2007 • 63 citations

Influence of the genetic polymorphism in the 5′-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers

2005 • 62 citations

Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome

2002 • 62 citations

Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients

2008 • 61 citations

A score for predicting response to pharmacotherapy in obsessive???compulsive disorder

2003 • 61 citations

Pharmacogenomics and therapeutic prospects in Alzheimer’s disease

2005 • 61 citations

Suggestive association between the C825T polymorphism of the G-protein β3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia

2005 • 60 citations

The influence on the schizophrenic symptoms by the DRD2Ser/Cys311 and −141C Ins/Del polymorphisms

2002 • 58 citations

Polymorphic cytochromes P450 and drugs used in psychiatry.

1999 • 57 citations

Polymorphism of the adrenergic receptor alpha 2a −1291C>G genetic variation and clozapine-induced weight gain

2005 • 56 citations

Possible association between the −2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain

2007 • 55 citations

Duration of Untreated Psychosis and Time to Treatment Response for Delusions and Hallucinations

2005 • 55 citations

Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients

2006 • 55 citations

Neuregulin genotype and medication response in Finnish patients with schizophrenia

2004 • 53 citations

Family and case–control association study of the tumor necrosis factor-alpha (TNF-α) gene with schizophrenia and response to antipsychotic medication

2006 • 53 citations

Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication

2007 • 52 citations

Cytochrome P-450 2D6*10 C188T Polymorphism Is Associated with Antipsychotic-Induced Persistent Tardive Dyskinesia in Chinese Schizophrenic Patients

2004 • 51 citations

Quinone oxidoreductase (NQO1) gene polymorphism (609C/T) may be associated with tardive dyskinesia, but not with the development of schizophrenia

2004 • 49 citations

Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3′-untranslated region

2008 • 48 citations

Pharmacological treatment and other predictors of treatment outcomes in previously untreated patients with schizophrenia: results from the European Schizophrenia Outpatient Health Outcomes (SOHO) study

2005 • 48 citations

Predictors of clozapine response in schizophrenia.

1994 • 47 citations

DOPAMINE D4 RECEPTOR GENE EXON III POLYMORPHISM AND INTERINDIVIDUAL VARIATION IN RESPONSE TO CLOZAPINE

2005 • 47 citations

Association in Japanese patients between neuroleptic malignant syndrome and functional polymorphisms of the dopamine D2 receptor gene

2004 • 46 citations

Relationship of ethnicity and gender to schizophrenia and pharmacology of neuroleptics.

1996 • 46 citations

Evidence for an Association between Polymorphism in the Serotonin-2A Receptor Variant (102T/C) and Increment of N100Am plitude in Schizophrenics Treated with Clozapine

2001 • 46 citations

Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: A preliminary study

2006 • 46 citations

Interaction between NOTCH4 and catechol-O-methyltransferase genotypes in schizophrenia patients with poor response to typical neuroleptics

2004 • 45 citations

Predictors of Treatment Nonresponse in Bipolar Children and Adolescents with Manic or Mixed Episodes

2004 • 45 citations

Comparison of Cytochrome P450 2C9 Genotyping Methods and Implications for the Clinical Laboratory

2004 • 43 citations

Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels

2007 • 43 citations

Effect of Serotonin Receptor 2A Gene Polymorphism on Mirtazapine Response in Major Depression

2007 • 43 citations

BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population

2008 • 43 citations

Rapid versus non-rapid cycling as a predictor of response to olanzapine and divalproex sodium for bipolar mania and maintenance of remission: Post hoc analyses of 47-week data

2005 • 42 citations

RGS4 Polymorphisms Predict Clinical Manifestations and Responses to Risperidone Treatment in Patients With Schizophrenia

2008 • 42 citations

Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients

2007 • 42 citations

SNAP-25 gene polymorphisms and weight gain in schizophrenic patients

2008 • 41 citations

Early Prediction of Clinical Response in Schizophrenia Patients Receiving the Atypical Antipsychotic Zotepine

2007 • 40 citations

Cytochrome P450 II D6 gene polymorphisms and the neuroleptic-induced extrapyramidal symptoms in Japanese schizophrenic patients

2003 • 39 citations

Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder

2008 • 39 citations

Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment

2005 • 39 citations

Clinical predictors of therapeutic response to clozapine in a sample of Turkish patients with treatment-resistant schizophrenia

2007 • 39 citations

Clozapine-induced concordant agranulocytosis in monozygotic twins

2001 • 36 citations

The Expression of Schizophrenia, Affective Disorder and Vulnerability to Tardive Dyskinesia in an Extensive Pedigree

1988 • 36 citations

Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and tardive dyskinesia in patients with schizophrenia

2006 • 36 citations

Possible predictors of neuroleptic-resistant schizophrenic relapse: influence of negative symptoms and acute extrapyramidal side effects.

1993 • 34 citations

Application of pharmacogenetics to psychotic disorders: the first consensus conference1Participants (in alphabetical order): A. Breier, L.E. DeLisi, F. Henn, W. Kalow, R. Kerwin, J. Kurth, B. Lerer, A. Malhotra, M. Masellis, H.J. Möller, V. Ozdemir, J. Peuskens, N.R. Schooler, V.M. Steen.12Conference organizers: M. Rietschel, J.L. Kennedy, F. Macciardi, H.Y. Meltzer.23Section Chairs: J.M. Kane and H.Y. Meltzer, J.L. Kennedy and S. Marder, F. Macciardi and M.M. Nöthen, A.G. Awad.3

1999 • 34 citations

Perceived parenting pattern and response to antidepressants in patients with major depression

1999 • 34 citations

Predictors of Relapse in a Prospective Study of Fluoxetine Treatment of Major Depression

2006 • 31 citations

Effects of substance abuse on hallucination rates and treatment responses in chronic psychiatric patients.

1994 • 30 citations

Pharmacogenetics of antipsychotic therapy: pivotal research issues and the prospects for clinical implementation

2006 • 30 citations

Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing

2005 • 30 citations

Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day

2003 • 29 citations

Increased prevalence of schizophrenia spectrum disorders in relatives of neuroleptic-nonresponsive schizophrenic patients

2005 • 29 citations

Sociodemographic Predictors of Response to Antidepressant Treatment

1997 • 28 citations

Obstetric complications predict treatment response in first-episode schizophrenia

1999 • 28 citations

An investigation of the α_1A‐adrenergic receptor gene and antipsychotic‐induced side‐effects

2007 • 25 citations

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis

2004 • 19 citations

Discovery and utilization of haplotypes for pharmacogenetic studies of psychotropic drug response

2002 • 14 citations

Possible predictors of response to fluvoxamine for depression

2002 • 13 citations

Genaissance Pharmaceuticals, Inc.

2002 • 6 citations

[Weight gain and clozapine].

1996 • 4 citations

Predictors of response to clonazepam as a mood stabilizer in protracted depression

2003 • 1 citations