Nonresponse to Clozapine and Ultrarapid CYP1A2 Activity

Prevalence of smoking among psychiatric outpatients

1986 • 1,059 citations

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1999 • 722 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans

1999 • 337 citations

Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients [published erratum appears in Am J Psychiatry 1991 Oct;148(10):1427]

1991 • 322 citations

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

1994 • 301 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

1997 • 219 citations

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine.

1996 • 200 citations

Ultrarapid metabolizers of debrisoquine: Characterization and PCR‐based detection of alleles with duplication of the CYP2D6 gene

1996 • 198 citations

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva

1994 • 179 citations

Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.

1999 • 174 citations

Elevated Levels of Clozapine in Serum After Addition of Fluvoxamine

1994 • 164 citations

Pharmacokinetic Interactions of Clozapine With Selective Serotonin Reuptake Inhibitors

1998 • 154 citations

The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6.

1992 • 116 citations

Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes.

1997 • 114 citations

Therapeutic Drug Monitoring Data on Olanzapine and Its N-Demethyl Metabolite in the Naturalistic Clinical Setting

2002 • 109 citations

Disposition of clozapine in man: lack of association with debrisoquine and S‐mephenytoin hydroxylation polymorphisms.

1994 • 103 citations

Will Routine Therapeutic Drug Monitoring Have a Place in Clozapine Therapy?

1997 • 103 citations

Clozapine

1995 • 101 citations

Treatment-Resistance to Clozapine in Association With Ultrarapid CYP1A2 Activity and the C → A Polymorphism in Intron 1 of the CYP1A2 Gene: Effect of Grapefruit Juice and Low-Dose Fluvoxamine

2001 • 96 citations

Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine

1998 • 93 citations

Determination of clozapine and its N-demethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection

1988 • 92 citations

Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2

2001 • 89 citations

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2

2002 • 87 citations

CYP1A2 Activity as Measured by a Caffeine Test Predicts Clozapine and Active Metabolite Norclozapine Steady-State Concentration in Patients With Schizophrenia

2001 • 83 citations

Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry

1996 • 80 citations

Fluvoxamine But Not Sertraline Inhibits the Metabolism of Olanzapine: Evidence From A Therapeutic Drug Monitoring Service

2001 • 71 citations

Monitoring of Plasma Clozapine Levels and Its Metabolites in Refractory Schizophrenic Patients

1996 • 67 citations

Identification of a novel splice‐site mutation in the CYP1A2 gene

2003 • 67 citations

Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene

1999 • 51 citations

Serum concentrations of clozapine and N -desmethylclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole

1998 • 49 citations

Absence of interaction between erythromycin and a single dose of clozapine

1999 • 43 citations

Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes

2001 • 40 citations

The effect of nefazodone on clozapine plasma concentrations

1999 • 21 citations

PREDICTING DRUG INTERACTIONS AND PHARMACOKINETIC VARIABILITY WITH IN VITRO METHODS: THE OLANZAPINE EXPERIENCE*

1999 • 20 citations