Simian Immunodeficiency Virus (SIV)gagDNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection

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DNA VACCINES

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Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

1999 • 384 citations

Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination

1997 • 364 citations

Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160

1992 • 340 citations

Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination

1997 • 314 citations

Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara

1996 • 307 citations

Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

1998 • 281 citations

Emergence of CTL Coincides with Clearance of Virus During Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys

1999 • 278 citations

Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors

1993 • 267 citations

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

1998 • 265 citations

Progress in the Development of an HIV-1 Vaccine

1998 • 262 citations

Simian immunodeficiency virus DNA vaccine trial in macaques

1996 • 240 citations

The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection

1997 • 232 citations

Immunization of non-human primates with DNA vaccines

1997 • 223 citations

Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus

1998 • 220 citations

Plasma SIV RNA Viral Load Determination by Real-Time Quantification of Product Generation in Reverse Transcriptase-Polymerase Chain Reaction

1998 • 205 citations

Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees

1987 • 197 citations

The Unenlarged Lymph Nodes of HIV-1–infected, Asymptomatic Patients with High CD4 T Cell Counts Are Sites for Virus Replication and CD4 T Cell Proliferation. The Impact of Highly Active Antiretroviral Therapy

1998 • 195 citations

A high frequency of Mamu‐A *01 in the rhesus macaque detected by polymerase chain reaction with sequence‐specific primers and direct sequencing

1997 • 186 citations

Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.

1991 • 171 citations

DNA Inoculation Induces Neutralizing Immune Responses Against Human Immunodeficiency Virus Type 1 in Mice and Nonhuman Primates

1993 • 166 citations

Augmentation and Suppression of Immune Responses to an HIV-1 DNA Vaccine by Plasmid Cytokine/Ig Administration

1998 • 150 citations

DNA Vaccines

1996 • 143 citations

Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A).

1996 • 142 citations

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys

1996 • 138 citations

Antisense-Oligonucleotide Therapy

1996 • 129 citations

In vivo protective anti‐HIV immune responses in non‐human primates through DNA immunization

1996 • 115 citations

Induction of Humoral and Cellular Immune Responses to the Human Immunodeficiency Type 1 Virus in Nonhuman Primates by in Vivo DNA Inoculation

1995 • 109 citations

Recombinant modified vaccinia virus Ankara–simian immunodeficiency virusgag polelicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer

1998 • 104 citations

Recombinant Virus Vaccine-Induced SIV-specific CD8 ⁺ Cytotoxic T Lymphocytes

1991 • 99 citations

Comparative Analysis of Cytotoxic T Lymphocytes in Lymph Nodes and Peripheral Blood of Simian Immunodeficiency Virus-Infected Rhesus Monkeys

1999 • 81 citations

Use of Major Histocompatibility Complex Class I/Peptide/β2M Tetramers To Quantitate CD8⁺Cytotoxic T Lymphocytes Specific for Dominant and Nondominant Viral Epitopes in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

1999 • 76 citations

Vaccination of rhesus monkeys with synthetic peptide in a fusogenic proteoliposome elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes.

1992 • 71 citations

Theoretical and Practical Considerations

2001 • 70 citations

A Dose-Ranging Study of a Prototype Synthetic HIV-1MN V3 Branched Peptide Vaccine

1996 • 68 citations

HIV-1 env DNA vaccine administered to rhesus monkeys elicits MHC class II-restricted CD4+ T helper cells that secrete IFN-gamma and TNF-alpha.

1997 • 66 citations

Cytotoxic T Lymphocyte and Helper T Cell Responses following HIV Polynucleotide Vaccination

1995 • 65 citations

Toward the development of DNA vaccines

1996 • 61 citations

Anti-HIV env immunities elicited by nucleic acid vaccines

1997 • 59 citations

DNA vaccines. Mechanisms for generation of immune responses.

1998 • 56 citations

Humoral and Cellular Immunities Elicited by HIV-1 DNA Vaccination

1996 • 47 citations

DNA Vaccines

1997 • 41 citations

Vaccination of Mice and Nonhuman Primates using HIV-Gene-Containing DNA

2015 • 39 citations

DNA Vaccines

1998 • 34 citations

Animal models for the study of human immunodeficiency virus infections

1992 • 31 citations

Safety and Immunogenicity of UBI HIV-1_MNOctameric V3 Peptide Vaccine Administered by Subcutaneous Injection

1997 • 29 citations

HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response.

1998 • 21 citations

DNA Vaccines for Bacteria and Viruses

1996 • 20 citations

DNA Vaccines

1996 • 19 citations

Adjuvant Is Required When Using Env Lipopeptide Construct to Induce HIV Type 1-Specific Neutralizing Antibody Responses in Micein Vivo

1998 • 5 citations