Simian immunodeficiency virus DNA vaccine trial in macaques

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

1990 • 593 citations

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.

1994 • 550 citations

Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA

1993 • 432 citations

Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus

1994 • 393 citations

Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus.

1991 • 357 citations

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA

1993 • 344 citations

Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160

1992 • 340 citations

Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes.

1995 • 333 citations

Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus

1995 • 325 citations

Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA

1995 • 297 citations

Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells

1991 • 297 citations

DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans.

1995 • 266 citations

Neutralizing and Infection-Enhancing Antibody Responses to Human Immunodeficiency Virus Type 1 in Long-Term Nonprogressors

1996 • 262 citations

Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins.

1992 • 262 citations

Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques

1994 • 251 citations

Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells

1991 • 247 citations

Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys

1991 • 238 citations

Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells

1995 • 219 citations

Complex determinants of macrophage tropism in env of simian immunodeficiency virus

1992 • 208 citations

Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay

1988 • 205 citations

Prevention of HIV Infection by Passive Immunization with HIV Immunoglobulin

1991 • 193 citations

Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization

1993 • 188 citations

Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus

1995 • 173 citations

HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.

1995 • 170 citations

DNA Inoculation Induces Neutralizing Immune Responses Against Human Immunodeficiency Virus Type 1 in Mice and Nonhuman Primates

1993 • 166 citations

The use of osmium-thiocarbohydrazide-osmium (OTO) and ferrocyanide-reduced osmium methods to enhance membrane contrast and preservation in cultured cells.

1984 • 158 citations

Protection of ferrets against influenza challenge with a DNA vaccine to the haemagglutinin

1994 • 156 citations

Pathogenic diversity of simian immunodeficiency viruses

1994 • 153 citations

Long-Term Anti-Nucleoprotein Cellular and Humoral Immunity Is Induced by Intramuscular Injection of Plasmid DNA Containing NP Gene

1993 • 150 citations

Use of DNAs Expressing HIV-1 Env and Noninfectious HIV-1 Particles to Raise Antibody Responses in Mice

1995 • 148 citations

A Qualitative Progression in HIV Type 1 Glycoprotein 120-Specific Cytotoxic Cellular and Humoral Immune Responses in Mice Receiving a DNA-Based Glycoprotein 120 Vaccine

1994 • 143 citations

A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge

1994 • 142 citations

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys

1996 • 138 citations

Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons

1992 • 138 citations

Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV

1990 • 136 citations

Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA.

1995 • 126 citations

Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro

1991 • 120 citations

Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences.

1991 • 109 citations

Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac

1993 • 91 citations

A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge

1995 • 87 citations

Titration and Characterization of Two Rhesus-Derived SIV_macChallenge Stocks

1994 • 84 citations

Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection

1993 • 77 citations

Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus

1992 • 74 citations

Cytotoxic T lymphocyte response against multiple simian immunodeficiency virusA (SIV) proteins in SIV-infected macaques.

1992 • 70 citations

Vaccine Protection Against HIV-2 Infection in Cynomolgus Monkeys

1991 • 68 citations

Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines

1994 • 64 citations

Reduced Virus Load in Rhesus Macaques Immunized with Recombinant gp160 and Challenged with Simian Immunodeficiency Virus

1994 • 64 citations

High-Titer Immune Responses Elicited by Recombinant Vaccinia Virus Priming and Particle Boosting Are Ineffective in Preventing Virulent SIV Infection

1994 • 61 citations

Heterogeneity of HIV-1 and HIV-2.

1995 • 60 citations

Passive Immunization of Cynomolgus Macaques with Immune Sera or a Pool of Neutralizing Monoclonal Antibodies Failed to Protect Against Challenge with SIVmac251

1994 • 57 citations

Effect of Dose and Immunization Schedule on Immune Response of Baboons to Recombinant Glycoprotein 120 of HIV-1

1989 • 50 citations

Prolonged Clinical Latency and Survival of Macaques Given a Whole Inactivated Simian Immunodeficiency Virus Vaccine

1994 • 44 citations

Determinants Of Antibody Response After Recombinant Gp160 Boosting In Vaccinia-Naive Volunteers Primed With Gp160-Recombinant Vaccinia Virus

1994 • 40 citations

Non-human primate models for AIDS vaccines.

1995 • 39 citations

Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein

1994 • 34 citations

Protection of vaccinia‐primed macaques against SIV _mne infection by combination immunization with recombinant vaccinia virus and SIV _mne gp160

1993 • 28 citations

Primate models for HIV vaccines.

1993 • 26 citations

Studies of Complement-Activating Antibodies in the SIV/Macaque Model of Acute Primary Infection and Vaccine Protection

1995 • 26 citations

Passive immunization of macaques against SIV infection

1994 • 25 citations

Human Immunodeficiency Virus Type 1 Envelope Glycoprotein-Specific Cytotoxic T Lymphocytes in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

1995 • 24 citations

Nucleic acid-based immunization against HIV-I: induction of protective in vivo immune responses.

1995 • 20 citations

Efficacy of inactivated whole HIV‐2 vaccines with various adjuvants in cynomolgus monkeys

1994 • 17 citations

The Dilemma of Developing and Testing AIDS Vaccines

2015 • 4 citations