Transcription Factor Pip Can Enhance DNA Binding by E47, Leading to Transcriptional Synergy Involving Multiple Protein Domains

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.

1996 • 361 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

The expression pattern ofId4, a novel dominant negative helix-loop-helix protein, is distinct fromId1,1d2andId3

1994 • 274 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1996 • 237 citations

Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

1993 • 228 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

1996 • 197 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

1993 • 188 citations

B-Cell-Specific DNA Binding by an E47 Homodimer

1995 • 187 citations

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

1994 • 167 citations

Id Proteins Id1 and Id2 Selectively Inhibit DNA Binding by One Class of Helix-Loop-Helix Proteins

1991 • 165 citations

B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits

1991 • 164 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

1992 • 155 citations

E2A and E2-2 are Subunits of B-Cell-Specific E2-Box DNA-Binding Proteins

1993 • 153 citations

Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 • 151 citations

Characterization of Functional Domains within the Multifunctional Transcription Factor, YY1

1995 • 139 citations

A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I

1997 • 136 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

PU.1 Recruits a Second Nuclear Factor to a Site Important for Immunoglobulin κ 3' Enhancer Activity

1992 • 107 citations

Phosphorylation of E47 as a Potential Determinant of B-Cell-Specific Activity

1996 • 103 citations

An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures

1994 • 102 citations

Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression.

1993 • 101 citations

Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors

1995 • 99 citations

Transcriptional Synergy between LIM-Homeodomain Proteins and Basic Helix-Loop-Helix Proteins: the LIM2 Domain Determines Specificity

1997 • 93 citations

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins.

1993 • 92 citations

PU.1 can participate in an active enhancer complex without its transcriptional activation domain

1997 • 87 citations

HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors

1992 • 86 citations

Cloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25

1996 • 80 citations

Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development

1991 • 43 citations

Functional Characterization of the Developmentally Controlled Immunoglobulin Kappa 3′ Enhancer: Regulation by Id, a Repressor of Helix-Loop-Helix Transcription Factors

1991 • 40 citations

PU.1 is a Component of a Multiprotein Complex Which Binds an Essential Site in the Murine Immunoglobulin λ2-4 Enhancer

1993 • 38 citations

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions

1993 • 38 citations

Activating Transcription Factor 1 and Cyclic AMP Response Element Modulator Can Modulate the Activity of the Immunoglobulin κ 3′ Enhancer

1995 • 37 citations

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers

1994 • 32 citations

Conformational Activation of a Basic Helix-Loop-Helix Protein (MyoDl) by the C-Terminal Region of Murine HSP90 (HSP84)

1992 • 26 citations

Ets Proteins: New Factors That Regulate Immunoglobulin Heavy-Chain Gene Expression

1993 • 25 citations

Lymphopoiesis: Transcription factors controlling B-cell development

1995 • 20 citations