The effect of sildenafil on nitric oxide–mediated vasodilation in healthy men

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

1992 • 4,765 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.

1993 • 1,542 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 1,065 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women

1994 • 708 citations

Hyperhomocyst(e)inemia Is Associated With Impaired Endothelium-Dependent Vasodilation in Humans

1997 • 698 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers

1996 • 563 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Clinical safety of oral sildenafil citrate (VIAGRATM) in the treatment of erectile dysfunction

1998 • 466 citations

Assessment and treatment of endothelial dysfunction in humans

1999 • 449 citations

Demonstration of Rapid Onset Vascular Endothelial Dysfunction After Hyperhomocysteinemia

1999 • 440 citations

Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.

1996 • 413 citations

Effects of sildenafil citrate on human hemodynamics

1999 • 369 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia

1997 • 360 citations

Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells

1995 • 352 citations

Nitric Oxide in the Penis: Physiology and Pathology

1997 • 352 citations

Sildenafil citrate and blood-pressure–lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist

1999 • 339 citations

An Electrically Calibrated Plethysmograph for Direct Measurement of Limb Blood Flow

1975 • 320 citations

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

2000 • 306 citations

Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide

1996 • 282 citations

Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm

1996 • 263 citations

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

1997 • 257 citations

Impaired Forearm Vasodilator Reserve in Patients with Microvascular Angina

1987 • 254 citations

Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women

1999 • 249 citations

HEMODYNAMIC EFFECTS OF SILDENAFIL IN MEN WITH SEVERE CORONARY ARTERY DISEASE

2000 • 197 citations

A new technique for recording compliance of human hand veins.

1981 • 165 citations

Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension

2000 • 158 citations

Pulsed Doppler: determination of diameter, blood flow velocity, and volumic flow of brachial artery in man

1981 • 132 citations

Sympathetic Activation by Sildenafil

2000 • 123 citations

Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction

1998 • 115 citations

Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men

1998 • 113 citations

cGMP-Mediated Negative-Feedback Regulation of Endothelial Nitric Oxide Synthase Expression by Nitric Oxide

1999 • 108 citations

Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation

1998 • 80 citations

STIMULATION OF P2y PURINOCEPTORS INDUCES, VIA NITRIC OXIDE PRODUCTION, ENDOTHELIUM-DEPENDENT RELAXATION OF HUMAN ISOLATED CORPUS CAVERNOSUM

1999 • 35 citations

Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers

1999 • 34 citations

Long-term exposure to β2-receptor agonist specifically desensitizes β-receptor—mediated venodilation

1993 • 30 citations