Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

1972 • 31,801 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Heart Disease: A Textbook of Cardiovascular Medicine.

1984 • 4,239 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension

1998 • 771 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 593 citations

Vitamin C Intake and Mortality among a Sample of the United States Population

1992 • 563 citations

Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

1993 • 550 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Natural Antioxidants in Human Health and Disease

1994 • 422 citations

Ascorbate Prevents the Interaction of Superoxide and Nitric Oxide Only at Very High Physiological Concentrations

1998 • 401 citations

Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure

1998 • 396 citations

Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels.

1993 • 395 citations

Long-Term Ascorbic Acid Administration Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1999 • 394 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia

1997 • 360 citations

An NADPH oxidase superoxide-generating system in the rabbit aorta

1995 • 295 citations

Thrombosis and Hemorrhage

2002 • 294 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients

1997 • 247 citations

Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension.

1985 • 205 citations

Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells

1997 • 186 citations

Blood pressure, dietary fats, and antioxidants

1988 • 161 citations

Both Intracellular and Extracellular Vitamin C Inhibit Atherogenic Modification of LDL by Human Vascular Endothelial Cells

1997 • 137 citations

Nonenzymatic Antioxidant Defense Systems

1994 • 102 citations

Reduced Responsiveness of Hypercholesterolemic Rabbit Aortic Smooth Muscle Cells to Nitric Oxide

1997 • 60 citations

Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 59 citations