Rer1p, a Retrieval Receptor for ER Membrane Proteins, Recognizes Transmembrane Domains in Multiple Modes

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum

1994 • 793 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

1997 • 644 citations

Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

1988 • 434 citations

An investigation of the role of transmembrane domains in Golgi protein retention.

1995 • 384 citations

Specific Retrieval of the Exocytic SNARE Snc1p from Early Yeast Endosomes

2000 • 363 citations

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

1991 • 359 citations

Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.

1989 • 339 citations

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

2001 • 324 citations

A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.

1989 • 296 citations

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

1990 • 266 citations

A Peptide Sequence Confers Retention and Rapid Degradation in the Endoplasmic Reticulum

1990 • 219 citations

Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.

1991 • 215 citations

A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

2002 • 181 citations

Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast

1997 • 161 citations

The yeast WBP1 is essential for oligosaccharyl transferase activity in vivo and in vitro.

1992 • 156 citations

Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer

2001 • 148 citations

Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.

1996 • 136 citations

Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyl transferase activity.

1993 • 125 citations

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Isolation and characterization of the gene encoding a specific processing alpha-mannosidase

1991 • 117 citations

Genes that allow yeast cells to grow in the absence of the HDEL receptor.

1992 • 112 citations

Polar Transmembrane Domains Target Proteins to the Interior of the Yeast Vacuole

2000 • 106 citations

Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p.

1995 • 105 citations

Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins

1997 • 105 citations

Identification of a gene required for membrane protein retention in the early secretory pathway.

1993 • 99 citations

A mutant cytochrome b5 with a lengthened membrane anchor escapes from the endoplasmic reticulum and reaches the plasma membrane.

1996 • 95 citations

Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum.

1993 • 86 citations

Glycoprotein biosynthesis in Saccharomyces cerevisiae

1989 • 85 citations

An essential 45 kDa yeast transmembrane protein reacts with anti-nuclear pore antibodies: purification of the protein, immunolocalization and cloning of the gene.

1991 • 72 citations

Mechanism of Residence of Cytochrome B(5), a Tail-Anchored Protein, in the Endoplasmic Reticulum

2000 • 62 citations

Targeting to the Endoplasmic Reticulum in Yeast Cells by Determinants Present in Transmembrane Domains

1998 • 62 citations

Retention of Cytochrome b5 in the Endoplasmic Reticulum Is Transmembrane and Luminal Domain-dependent

1998 • 56 citations

Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain

2000 • 54 citations

Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER-->Golgi transport in yeast.

1994 • 51 citations

Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.

1993 • 46 citations

Identification of the structural gene for dipeptidyl aminopeptidase yscV (DAP2) of Saccharomyces cerevisiae

1987 • 31 citations

An essential 45 kDa yeast transmembrane protein reacts with anti-nuclear pore antibodies: purification of the protein, immunolocalization and cloning of the gene.

1991 • 24 citations

The Arabidopsis thaliana RER1 gene family: its potential role in the endoplasmic reticulum localization of membrane proteins.

1999 • 23 citations

The processing α1,2-mannosidase of Saccharomyces cerevisiae depends on Rer1p for its localization in the endoplasmic reticulum

1999 • 22 citations

Introduction of Kex2 cleavage sites in fusion proteins for monitoring localization and transport in yeast secretory pathway

2000 • 4 citations