Protein quality control: triage by chaperones and proteases.

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

PROTEASES AND THEIR TARGETS IN ESCHERICHIA COLI

1996 • 708 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

Regulation by proteolysis: energy-dependent proteases and their targets

1992 • 458 citations

Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma 32.

1995 • 430 citations

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1996 • 406 citations

Proteases and protein degradation inEscherichia coli

1992 • 387 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

ClpB is the Escherichia coli heat shock protein F84.1

1991 • 336 citations

ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities.

1993 • 317 citations

The YTA10–12 Complex, an AAA Protease with Chaperone-like Activity in the Inner Membrane of Mitochondria

1996 • 312 citations

Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB.

1995 • 308 citations

Homology in Structural Organization BetweenE. coliClpAP Protease and the Eukaryotic 26 S Proteasome

1995 • 303 citations

Disassembly of the Mu transposase tetramer by the ClpX chaperone.

1995 • 276 citations

FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit.

1995 • 264 citations

Requirement for the Yeast Gene LON in Intramitochondrial Proteolysis and Maintenance of Respiration

1994 • 256 citations

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

1995 • 247 citations

Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.

1993 • 247 citations

Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.

1994 • 237 citations

HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome.

1996 • 229 citations

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression

1993 • 229 citations

Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli.

1984 • 217 citations

Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli.

1992 • 214 citations

ATP-dependent Degradation of CcdA by Lon Protease

1996 • 211 citations

Escherichia coli heat shock gene mutants are defective in proteolysis.

1988 • 205 citations

Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli.

1992 • 199 citations

Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.

1991 • 183 citations

[25] ATP-dependent protease La (Lon) from Escherichia coli

1994 • 179 citations

GENETICS OF PROTEOLYSIS IN ESCHERICHIA COLI

1989 • 173 citations

A gene regulating the heat shock response in Escherichia coli also affects proteolysis.

1984 • 171 citations

Promotion of Mitochondrial Membrane Complex Assembly by a Proteolytically Inactive Yeast Lon

1996 • 170 citations

Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli.

1996 • 164 citations

Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates.

1994 • 162 citations

FtsH (HflB) Is an ATP-dependent Protease Selectively Acting on SecY and Some Other Membrane Proteins

1996 • 159 citations

Involvement of the Molecular Chaperone Ydj1 in the Ubiquitin-Dependent Degradation of Short-Lived and Abnormal Proteins in Saccharomyces cerevisiae

1996 • 153 citations

Involvement of FtsH in protein assembly into and through the membrane. I. Mutations that reduce retention efficiency of a cytoplasmic reporter.

1994 • 149 citations

HSP100/Clp proteins: a common mechanism explains diverse functions

1996 • 147 citations

A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein

1994 • 132 citations

Rapid degradation of an abnormal protein in Escherichia coli involves the chaperones GroEL and GroES.

1994 • 128 citations

The Clp ATPases define a novel class of molecular chaperones

1996 • 128 citations

ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis.

1996 • 126 citations

Genetic evidence for a functional relationship between Hsp104 and Hsp70

1993 • 124 citations

Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation

1995 • 120 citations

Degradation in vitro of bacteriophage lambda N protein by Lon protease from Escherichia coli.

1987 • 119 citations

Selectivity of Intracellular Proteolysis: Protein Substrates Activate the ATP-Dependent Protease (La)

1986 • 112 citations

Six‐fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP‐dependent activator, ClpY

1996 • 108 citations

Trigger factor is involved in GroEL-dependent protein degradation in Escherichia coli and promotes binding of GroEL to unfolded proteins.

1995 • 106 citations

Hsp78, a Clp homologue within mitochondria, can substitute for chaperone functions of mt-hsp70.

1995 • 100 citations

Yta10p is required for the ATP‐dependent degradation of polypeptides in the inner membrane of mitochondria

1994 • 96 citations

DnaJ, DnaK, and GrpE heat shock proteins are required in oriP1 DNA replication solely at the RepA monomerization step.

1992 • 87 citations

Mechanism of protein remodeling by ClpA chaperone

1997 • 84 citations

Afg3p, a mitochondrial ATP‐dependent metalloprotease, is involved in degradation of mitochondrially‐encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and V

1996 • 83 citations

Participation of Escherichia coli heat shock proteins DnaJ, DnaK, and GrpE in P1 plasmid replication

1989 • 79 citations

Regulated protein degradation in mitochondria

1996 • 79 citations

Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial function

1994 • 73 citations

Role of the Heat Shock Protein DnaJ in the Lon-dependent Degradation of Naturally Unstable Proteins

1996 • 73 citations

Divergent effects of a dnaK mutation on abnormal protein degradation in Escherichia coli

1988 • 55 citations

Suppression of ftsH mutant phenotypes by overproduction of molecular chaperones

1996 • 55 citations

The Mitochondrial ClpB Homolog Hsp78 Cooperates with Matrix Hsp70 in Maintenance of Mitochondrial Function

1995 • 53 citations

Physiological roles of the DnaK and GroE stress proteins: catalysts of protein folding or macromolecular sponges?

1991 • 47 citations

Overproduction and purification of SulA fusion protein in Escherichia coli and its degradation by Lon protease in vitro

1995 • 35 citations

Formation in vitro of complexes between an abnormal fusion protein and the heat shock proteins from Escherichia coli and yeast mitochondria

1991 • 34 citations

Molecular Chaperones: Resurrection or destruction?

1995 • 27 citations

Roles for Energy-Dependent Proteases in Regulatory Cascades

1996 • 13 citations

Overproduction and purification of SulA fusion protein in Escherichia coli and its degradation by Lon protease in vitro

1995 • 9 citations

Increased ATP-dependent proteolytic activity in lon-deficient Escherichia coli strains lacking the DnaK protein

1991 • 6 citations