T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Inflammatory Mediators in Late Antigen-Induced Rhinitis

1985 • 708 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Activation of CD4+ T cells, increased T-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1993 • 593 citations

Interleukin 4 is localized to and released by human mast cells.

1992 • 589 citations

Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia.

1992 • 572 citations

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

1993 • 561 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

The Influx of Inflammatory Cells into Nasal Washings during the Late Response to Antigen Challenge: Effect of Systemic Steroid Pretreatment

1988 • 285 citations

Immunohistology of the nasal mucosa in seasonal allergic rhinitis: Increases in activated eosinophils and epithelial mast cells

1992 • 275 citations

IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals.

1992 • 266 citations

Immunohistology of the Nasal Mucosa Following Allergen-induced Rhinitis: Identification of Activated T Lymphocytes, Eosinophils, and Neutrophils

1992 • 233 citations

Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.

1992 • 227 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells.

1992 • 223 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

Preferential messenger RNA expression of Th1-type cells (IFN-gamma+, IL-2+) in classical delayed-type (tuberculin) hypersensitivity reactions in human skin.

1992 • 192 citations

Intraepithelial Migration of Nasal Mucosal Mast Cells in Hay Fever

1986 • 164 citations

Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge.

1987 • 161 citations

T Cells Are the Principal Source of Interleukin-5 mRNA in Allergen-induced Rhinitis

1993 • 142 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Th2 cells mediate IL-4-dependent local tissue inflammation.

1993 • 140 citations

Application of monoclonal antibodies against major basic protein (BMK‐13) and eosinophil cationic protein (EG1 and EG2) for quantifying eosinophils in bronchial biopsies from atopic asthma

1992 • 95 citations

A biopsy method to obtain high quality specimens of nasal mucosa.

1988 • 80 citations

T cell-specific negative regulation of transcription of the human cytokine IL-4.

1992 • 67 citations

Hydrocortisone inhibition of human interleukin-4.

1992 • 56 citations

Allergen-induced changes in the nasal mucous membrane in seasonal allergic rhinitis: Effect of nedocromil sodium

1990 • 49 citations

The effect of IL-4 on human nasal mucosal responses

1992 • 13 citations