Expression of Activation Markers and Cytokine mRNA by Peripheral Blood CD4 and CD8 T Cells in Atopic and Nonatopic Childhood Asthma: Effect of Inhaled Glucocorticoid Therapy

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Statement on Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma

1987 • 2,165 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

T cells and eosinophils in the pathogenesis of asthma

1992 • 585 citations

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.

1994 • 498 citations

Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.

1997 • 416 citations

Identification of T lymphocytes, Macrophages, and Activated Eosinophils in the Bronchial Mucosa in Intrinsic Asthma: Relationship to Symptoms and Bronchial Responsiveness

1992 • 414 citations

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

1996 • 413 citations

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma.

1991 • 395 citations

The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences

1999 • 354 citations

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1995 • 342 citations

Prednisolone Treatment in Asthma Is Associated with Modulation of Bronchoalveolar Lavage Cell Interleukin-4, Interleukin-5, and Interferon-γ Cytokine Gene Expression

1993 • 307 citations

Management of asthma: a consensus statement.

1989 • 306 citations

A Novel T Cell-Regulated Mechanism Modulating Allergen-Induced Airways Hyperreactivity in BALB/c Mice Independently of IL-4 and IL-5

1998 • 291 citations

Identification of T-lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma

1992 • 279 citations

CD4 T-Lymphocyte Activation in Asthma Is Accompanied by Increased Serum Concentrations of Interleukin-5: Effect of Glucocorticoid Therapy

1993 • 264 citations

Asthma: a follow up statement from an international paediatric asthma consensus group.

1992 • 255 citations

The synergy between naive and memory T cells during activation

1991 • 247 citations

Heterogeneity of Bronchial Asthma

1981 • 232 citations

Relationship between IL-4 and IL-5 mRNA Expression and Disease Severity in Atopic Asthma

1997 • 206 citations

Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe

1998 • 205 citations

Increase in hospital admissions for childhood asthma: trends in referral, severity, and readmissions from 1970 to 1985 in a health region of the United Kingdom.

1989 • 193 citations

Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.

1993 • 190 citations

T CELL SUBSETS AND CYTOKINES IN ALLERGIC AND NON-ALLERGIC CHILDREN. I. ANALYSIS OF IL-4, IFN-γ AND IL-13 mRNA EXPRESSION AND PROTEIN PRODUCTION

1997 • 152 citations

Peripheral blood CD4 but not CD8 t-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy.

1995 • 150 citations

Natural history of allergy in asthmatic children followed to adult life

1981 • 82 citations

Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4–Deficient Mice

2000 • 67 citations

Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine.

1983 • 64 citations

Inhaled Glucocorticoid Therapy of Childhood Asthma Is Associated With Reduced Peripheral Blood T Cell Activation and ‘Th2-Type’ Cytokine mRNA Expression

1997 • 60 citations

Glucocorticoids Inhibit Calcium- and Calcineurin-Dependent Activation of the Human IL-4 Promoter

2000 • 59 citations

Activated peripheral blood CD4 and CD8 T‐lymphocytes in child asthma: correlation with eosinophilia and disease severity

1994 • 46 citations

Asthma in children: Prevalence, treatment, and sensitization

2000 • 42 citations

The topical glucocorticoids beclomethasone dipropionate and fluticasone propionate inhibit human T-cell allergen-induced production of IL-5, IL-3 and GM-CSF mRNA and protein

2001 • 17 citations

The topical glucocorticoids beclomethasone dipropionate and fluticasone propionate inhibit human T‐cell allergen‐induced production of IL‐5, IL‐3 and GM‐CSF mRNA and protein

2001 • 16 citations

Deleted Work

1955 • 0 citations