The Key Role of IL-6–Arginase Cascade for Inducing Dendritic Cell–Dependent CD4+ T Cell Dysfunction in Tumor-Bearing Mice

Dendritic cells and the control of immunity

1998 • 14,345 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Dendritic Cells

2001 • 2,164 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Taking dendritic cells into medicine

2007 • 2,044 citations

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

2006 • 1,715 citations

Immunosuppressive Strategies that are Mediated by Tumor Cells

2006 • 1,662 citations

Regulation of immune responses by L-arginine metabolism

2005 • 1,636 citations

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

2007 • 1,079 citations

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

2010 • 1,030 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

2007 • 1,006 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology

2004 • 985 citations

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

2008 • 883 citations

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

2003 • 811 citations

l-arginine availability regulates T-lymphocyte cell-cycle progression

2006 • 801 citations

Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial

2004 • 790 citations

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

2008 • 782 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

2007 • 728 citations

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

2008 • 597 citations

Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma

2000 • 547 citations

Determination of arginase activity in macrophages: a micromethod

1994 • 536 citations

Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.

2003 • 516 citations

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

2003 • 502 citations

IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation

2004 • 487 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Suppression of Antitumor Immunity by IL-10 and TGF-β-Producing T Cells Infiltrating the Growing Tumor: Influence of Tumor Environment on the Induction of CD4+ and CD8+ Regulatory T Cells

2006 • 407 citations

Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy

2000 • 376 citations

Serum interleukin‐6 levels reflect the disease status of colorectal cancer

2003 • 337 citations

Regulatory T cells in immune surveillance and treatment of cancer

2006 • 257 citations

Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy

2010 • 225 citations

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

2006 • 222 citations

IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells

2005 • 201 citations

Interleukin-6 Blood Level Is Associated With Circulating Carcinoembryonic Antigen and Prognosis in Patients With Colorectal Cancer

2000 • 192 citations

Interleukin-6, Interleukin-10, and Vascular Endothelial Growth Factor in Metastatic Renal Cell Carcinoma: Prognostic Value of Interleukin-6—From the Groupe Français d'Immunothérapie

2004 • 173 citations

Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4+ T cells from patients with GI malignancy

2011 • 123 citations

Anti‐<scp>IL</scp>‐6 receptor m<scp>A</scp>b eliminates myeloid‐derived suppressor cells and inhibits tumor growth by enhancing <scp>T</scp>‐cell responses

2012 • 121 citations

Interleukin‐6 induces both cell growth and VEGF production in malignant mesotheliomas

2006 • 107 citations

Serum interleukin-10 levels in patients with advanced gastrointestinal malignancies

1999 • 90 citations

IL‐6 as an intracrine growth factor for renal carcinoma cell lines

2004 • 74 citations

IL‐6, its receptors and its relationship with bcl‐2 and bax proteins in infiltrating and in situ human breast carcinoma

2005 • 70 citations

Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells

2011 • 56 citations

Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer

2010 • 53 citations

An Essential Role of Antigen-Presenting Cell/T-Helper Type 1 Cell-Cell Interactions in Draining Lymph Node during Complete Eradication of Class II–Negative Tumor Tissue by T-Helper Type 1 Cell Therapy

2006 • 47 citations

Significance of the Correlation Between the Expression of Interleukin 6 and Clinical Features in Patients With Non-Small Cell Lung Cancer

2012 • 40 citations

Prognostic value of IL-6 in localized prostatic cancer.

2010 • 31 citations

3‐Methylcholanthrene‐induced transforming growth factor‐β‐producing carcinomas, but not sarcomas, are refractory to regulatory T cell‐depletion therapy

2009 • 10 citations