Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-κB activation in rat hepatocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

A Comparison of Tacrolimus (FK 506) and Cyclosporine for Immunosuppression in Liver Transplantation

1994 • 877 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection

1994 • 635 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates

1991 • 340 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.

1992 • 258 citations

Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.

1991 • 192 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone

1991 • 161 citations

A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.

1995 • 155 citations

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

1994 • 142 citations

Molecular Cloning of the Rat Inducible Nitric Oxide Synthase Gene Promoter

1996 • 126 citations

Towards an understanding of the signal transduction pathways for interleukin 1

1995 • 123 citations

Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells

1996 • 111 citations

Human Inducible Nitric Oxide Synthase Gene Is Transcriptionally Regulated by Nuclear Factor-κB Dependent Mechanism

1996 • 92 citations

Metabolic Effects of Cyclosporin A and FK 506 in Liver Transplant Recipients

1993 • 92 citations

Cyclosporin A Inhibits Nitric Oxide Synthase Induction in Vascular Smooth Muscle Cells

1995 • 90 citations

Stimulation of glycogen degradation by prostaglandin E2 in primary cultured rat hepatocytes

1993 • 77 citations

NITRIC OXIDE GENERATION

1994 • 74 citations

Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity.

1995 • 61 citations

EVIDENCE FOR INCREASED NITRIC OXIDE PRODUCTION AFTER LIVER TRANSPLANTATION IN HUMANS

1995 • 59 citations

The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1β at a translational step, but not at a transcriptional step, in hepatocytes

1997 • 58 citations

Quantification of Cell Nuclei Isolated from Hepatocytes by Cell Lysis with Nonionic Detergent in Citric Acid.

1991 • 55 citations

The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1? at a translational step, but not at a transcriptional step, in hepatocytes

1997 • 53 citations

Interleukin 1β-Induced Expression of Nitric Oxide Synthase in Rat Renal Mesangial Cells Is Suppressed by Cyclosporin A

1995 • 51 citations

Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

1994 • 51 citations

Immunologic Mechanisms of Hepatic Allograft Rejection

1992 • 46 citations

A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogeneic immune response.

1992 • 40 citations

Increased nitric oxide production in the liver in the perioperative period of partial hepatectomy with Pringle's maneuver

1998 • 36 citations

Detection of the FK506-FKBP-Calcineurin Complex by a Simple Binding Assay

1993 • 27 citations

Cyclosporin A protects pancreatic islet cells from nitric oxide‐dependent macrophage cytotoxicity

1992 • 25 citations

Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model

1996 • 23 citations

FK 506 ameliorates the hepatic injury associated with ischemia

1990 • 20 citations

TRANSPLANTATION FOR FULMINANT HEPATIC FAILURE

1996 • 18 citations

Protective effect of FK 506 against hepatic ischemia in rats.

1991 • 15 citations

Nitric oxide and hepatic ischemic injury in human orthotopic liver transplantation.

1995 • 10 citations

FK 506 inhibits nitric oxide production by cells infiltrating sponge matrix allografts.

1991 • 7 citations