Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats

Caspases: Enemies Within

1998 • 6,923 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon

1989 • 1,681 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis

1987 • 678 citations

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

1995 • 400 citations

Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes

1991 • 368 citations

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

1996 • 355 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNFα and LIF in the rat brain

1991 • 330 citations

Nitric Oxide and Apoptosis: Another Paradigm for the Double-Edged Role of Nitric Oxide

1997 • 317 citations

Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis

1995 • 301 citations

Novel nonsterodial anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

1994 • 293 citations

A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats

1995 • 270 citations

Peroxynitrite-induced rat colitis—A new model of colonic inflammation

1993 • 264 citations

An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis

1990 • 244 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

[43] Interleukin-1β converting enzyme

1994 • 208 citations

NO‐naproxen vs. naproxen: ulcerogenic, analgesic and anti‐inflammatory effects

1997 • 189 citations

Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers

1993 • 188 citations

Superoxide Modulates the Oxidation and Nitrosation of Thiols by Nitric Oxide-derived Reactive Intermediates

1997 • 187 citations

A diclofenac derivative without ulcerogenic properties

1994 • 167 citations

5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.

1991 • 136 citations

Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: Role in resistance to damage

1997 • 121 citations

Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats

1995 • 105 citations

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

1999 • 95 citations

Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils

1997 • 85 citations

Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine

1997 • 76 citations

Possible mode of action of 5-aminosalicylic acid

1987 • 75 citations

Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis

1997 • 75 citations

Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease

1991 • 73 citations

Simultaneous determination of nitrite and nitrate anions in plasma, urine and cell culture supernatants by high-performance liquid chromatography with post-column reactions

1996 • 71 citations

Markedly reduced intestinal toxicity of a diclofenac derivative

1994 • 70 citations

Nitric oxide‐releasing NSAIDs inhibit interleukin‐1β converting enzyme‐like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα

1999 • 65 citations

Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti‐inflammatory derivatives with gastrointestinalsparing properties

1996 • 49 citations

TNFα processing enzyme inhibitors prevent aspirin‐induced TNFα release and protect against gastric mucosal injury in rats

1998 • 49 citations

Cytokine mRNA expression profiles in rats infected with the intestinal nematode Nippostrongylus brasiliensis

1995 • 46 citations

A Synthetic Inhibitor of Interleukin-lβ Converting Enzyme Prevents Endotoxin-Induced Interleukin-lβ ProductionIn VitroandIn Vivo

1995 • 41 citations

Scavenging effect of 5-aminosalicylic acid on neutrophil-derived oxidants

1991 • 40 citations

Human immunodeficiency virus-induced enteropathy

1991 • 35 citations

5-Aminosalicylic acid concentration in mucosal interstitium of cat small and large intestine

1989 • 29 citations