Nitric oxide‐releasing NSAIDs inhibit interleukin‐1β converting enzyme‐like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

NO at work

1994 • 1,493 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

1990 • 563 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

1995 • 340 citations

Nitric oxide prevents leukocyte adherence: role of superoxide

1993 • 331 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit

1991 • 284 citations

A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats

1995 • 270 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.

1991 • 247 citations

Internalization of fluorescent vasotocin-receptor agonist and antagonist in the toad bladder

1990 • 211 citations

[43] Interleukin-1β converting enzyme

1994 • 208 citations

Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin

1995 • 207 citations

Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha.

1994 • 192 citations

A diclofenac derivative without ulcerogenic properties

1994 • 167 citations

A simple and repid method for detection of apoptosis in human cells

1992 • 163 citations

Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative.

1995 • 158 citations

Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence

1996 • 148 citations

Mechanism of deletion of endothelial cells during regression of the corpus luteum.

1984 • 143 citations

Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats

1995 • 142 citations

MECHANISMS OF ENDOTHELIAL CELL INJURY IN ACUTE INFLAMMATION

1994 • 136 citations

Hemodynamics and Vascular Endothelial Biology

1993 • 128 citations

Molecular aspects of signal transduction of shear stress in the endothelial cell

1994 • 126 citations

Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa

1994 • 94 citations

Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats

1992 • 82 citations

Molecular determinants of aspirin-induced neutrophil adherence to endothelial cells

1993 • 80 citations

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

1988 • 80 citations

Endotoxin-induced changes of endothelial cell viability and permeability: Protective effect of a 21-aminosteroid

1995 • 78 citations

TNFα processing enzyme inhibitors prevent aspirin‐induced TNFα release and protect against gastric mucosal injury in rats

1998 • 49 citations

NSAIDs upregulate β₂‐integrin expression on human neutrophils through a calcium‐dependent pathway

1997 • 28 citations

Nitric oxide modulates pepsinogen secretion induced by calcium-mediated agonist in guinea pig gastric chief cells

1995 • 28 citations

Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat.

1996 • 17 citations

Effects of Acute and Chronic Administration of Acebutolol on the Right Ventricular Effective Refractory Period in Conscious Dogs

1993 • 10 citations