The Differential Effect of Food Intake and β-Adrenergic Stimulation on Adipose-Derived Hormones and Cytokines in Man

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid¹

1998 • 1,562 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

1997 • 919 citations

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

1998 • 843 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction

1997 • 543 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

1997 • 405 citations

Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels¹

1997 • 400 citations

Direct effects of leptin on brown and white adipose tissue.

1997 • 377 citations

Depot-related gene expression in human subcutaneous and omental adipocytes.

1998 • 337 citations

Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action

1997 • 311 citations

Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia.

1992 • 283 citations

Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans¹

1997 • 278 citations

In VitroLipolytic Effect of Leptin on Mouse Adipocytes: Evidence for a Possible Autocrine/Paracrine Role of Leptin

1997 • 264 citations

Strain-Specific Response toβ₃-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice¹

1997 • 260 citations

Endocrinologic and metabolic effects of interleukin-6 in humans

1995 • 254 citations

IL-6-regulated transcription factors

1997 • 236 citations

Polymorphisms of the tumour necrosis factor‐α gene, coronary heart disease and obesity

1998 • 230 citations

Catecholaminergic innervation of white adipose tissue in Siberian hamsters

1995 • 173 citations

Immobilization Stress May Increase Plasma lnterleukin-6 via Central and Peripheral Catecholamines

1994 • 171 citations

Influences of Fat and Carbohydrate on Postprandial Sleepiness, Mood, and Hormones

1997 • 131 citations

Adrenergic regulation of adipocyte metabolism

1997 • 129 citations

Increased sympathetic activity in rat white adipose tissue during prolonged fasting

1997 • 124 citations

Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism.

1993 • 123 citations

In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity.

1997 • 121 citations

Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat

1998 • 118 citations

Leptin Signaling in the Hypothalamus of Normal Rats in Vivo**This work was supported in part by a Boston Obesity Nutrition Research Center Grant (to J.C.C.), NIH Grant DK-50411 (to R.J.S.), and NIH Diabetes and Endocrinology Center Grant DK-36836 (to R.J.S.).

1998 • 110 citations

Potential Role of TNFα and Lipoprotein Lipase as Candidate Genes for Obesity ,

1997 • 92 citations

Effect of isoprenaline on plasma leptin and lipolysis in humans

1998 • 84 citations

Autocrine Inhibition of Leptin Production by Tumor Necrosis Factor-α (TNF-α) through TNF-α Type-I Receptorin Vitro

1998 • 65 citations

Tumor Necrosis Factor Acutely Increases Plasma Levels of Very Low Density Lipoproteins of Normal Size and Composition*

1990 • 65 citations

Plasma Leptin and Hunger Ratings in Healthy Humans

1998 • 62 citations

Overlapping and distinct signals through leptin receptor (OB‐R) and a closely related cytokine signal transducer, gp130

1997 • 50 citations

Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFα expression

1998 • 50 citations

Role of sympathetic nerves in effects of estradiol on rat white adipose tissue

1991 • 48 citations

Adrenergic regulation of human adipose tissue metabolism in situ during mental stress.

1993 • 45 citations

Estrogen biosynthesis in adipose tissue: regulation by paracrine and autocrine mechanisms.

1996 • 35 citations

Lipolytic catecholamine resistance linked to α2-adrenoceptor sensitivity—a metabolic predictor of weight loss in obese subjects

1997 • 34 citations

The role of altered sympathetic nervous system activity in the pathogenesis of obesity

1996 • 32 citations

Lactate Metabolism of Subcutaneous Adipose Tissue Studied by Open Flow Microperfusion

1998 • 31 citations

From physiology to neuroendocrinology: a reappraisal of risk factors of body weight gain in humans.

1998 • 31 citations

Does the Route of Feeding Modify the Inflammatory Response?

1994 • 27 citations

The relationship of IL-6 to hormonal mediators, fuel utilization, and systemic hypermetabolism after surgical trauma.

1996 • 26 citations

Interleukin-6 can prime THP-1 macrophages for enhanced production of tumor necrosis factor-α in response to LPS

1992 • 15 citations

Effect of CL316,243, a Highly Specific β₃-Adrenoceptor Agonist, on Lipolysis of Human and Rat Adipocytes

1996 • 14 citations