Expression of CCK2 receptors in the murine pancreas: Proliferation, transdifferentiation of acinar cells, and neoplasia

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer

2000 • 580 citations

Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

2000 • 528 citations

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.

1993 • 272 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice

1997 • 238 citations

G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo.

1996 • 237 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 213 citations

Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice

1997 • 202 citations

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α

1999 • 201 citations

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

1998 • 197 citations

I. CCK receptors: an exemplary family

1998 • 177 citations

Identification of K-ras Mutations in Pancreatic Juice in the Early Diagnosis of Pancreatic Cancer

1995 • 170 citations

Human Colorectal Cancers Express a Constitutively Active Cholecystokinin-B/Gastrin Receptor That Stimulates Cell Growth

2000 • 149 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 140 citations

The peripheral cholecystokinin receptors

1993 • 125 citations

Pancreatic carcinoma in azaserine-treated rats: Induction, classification and dietary modulation of incidence

1981 • 122 citations

Closing the gastrin loop in pancreatic carcinoma

2000 • 117 citations

Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKBReceptors

1999 • 108 citations

Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor α

1992 • 107 citations

Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma.

1997 • 99 citations

Cholecystokinin and regulation of pancreatic acinar cell function

1993 • 94 citations

Cholecystokinin-B/gastrin receptor signaling pathway involves tyrosine phosphorylations of p125FAK and p42MAP.

1994 • 87 citations

Exocrine pancreatic disorders in transsgenic mice expressing human keratin 8

1999 • 79 citations

Experimental Induction of Pancreatic Adenocarcinoma in Rats 2

1975 • 76 citations

Gastrin Stimulates Tyrosine Phosphorylation of Insulin Receptor Substrate 1 and Its Association with Grb2 and the Phosphatidylinositol 3-Kinase

1996 • 76 citations

Differential Activation of p70 and p85 S6 Kinase Isoforms during Cardiac Hypertrophy in the Adult Mammal

1998 • 71 citations

Expression and processing of gastrin in pancreatic adenocarcinoma

2000 • 68 citations

Origin of tubular complexes developing during induction of pancreatic adenocarcinoma by 7,12-dimethylbenz(a)anthracene.

1978 • 66 citations

Differential expression of A- and B-subtypes of cholecystokinin/gastrin receptors in the developing calf pancreas.

1993 • 65 citations

Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon

1997 • 61 citations

Characterisation of gastrin receptors on a rat pancreatic acinar cell line (AR42J). A possible model for studying gastrin mediated cell growth and proliferation.

1987 • 59 citations

Species and Rat Strain Variation in Pancreatic Nodule Induction by Azaserine 2

1977 • 54 citations

Animal models of exocrine pancreatic carcinogenesis

1987 • 46 citations

Proliferative Lesions of the Exocrine Pancreas: Relationship to Corn Oil Gavage in the National Toxicology Program

1985 • 46 citations

Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion

1998 • 45 citations

Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model. An electron-microscopic and immunohistochemical study.

1988 • 40 citations

III. Lessons learned from gastrin gene deletion in mice

1999 • 33 citations

Pharmacological and biochemical evidence for the simultaneous expression of CCK_B/gastrin and CCK_A receptors in the pig pancreas

1997 • 27 citations

Molecular mechanisms for the growth factor action of gastrin

1996 • 26 citations

Expression of peptide receptors in human endocrine tumours of the pancreas.

1997 • 23 citations

The CCK_B/gastrin receptor is coupled to the regulation of enzyme secretion, protein synthesis and p70 S6 kinase activity in acinar cells from ElasCCKB transgenic mice

1999 • 17 citations

Overexpression of messenger RNA for cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine-induced rat pancreatic carcinoma

1993 • 17 citations

Novel expression of gastrin (CCK-B) receptors in pancreatic carcinomas and dysplastic pancreas from transgenic mice

1994 • 16 citations

Atypical acinar cell lesions of the pancreas in mice induced by 4-hydroxyaminoquinoline-1-oxide

1987 • 11 citations

Gastrin Receptor Expression during Azaserine-Induced Rat Pancreatic Carcinogenesis

1996 • 8 citations

Human cholecystokinin-A receptor is not an oncofetal protein.

2000 • 6 citations