Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1995 • 885 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1995 • 382 citations

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

1993 • 368 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

The molecular basis for cell cycle delays following ionizing radiation: a review

1994 • 293 citations

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control

1996 • 253 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

Identification of HIV-1 vpr product and function.

1990 • 251 citations

Progression to AIDS in the absence of a gene for vpr or vpx

1995 • 243 citations

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 Isolate

1994 • 237 citations

A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

1991 • 235 citations

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

1996 • 235 citations

Evolution of the primate lentiviruses: evidence from vpx and vpr.

1992 • 232 citations

Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus

1993 • 220 citations

Vpr-induced cell cycle arrest is conserved among primate lentiviruses

1996 • 192 citations

Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

1996 • 173 citations

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles

1995 • 164 citations

G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.

1993 • 162 citations

The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.

1990 • 159 citations

Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants

1992 • 117 citations

Feedback controls and G2 checkpoints: Fission yeast as a model system

1993 • 113 citations

Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe

1996 • 111 citations

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.

1986 • 107 citations

Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective

1995 • 104 citations

Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard.

1992 • 96 citations

Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr

1995 • 91 citations

Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. NIAID AIDS Clinical Trials Group.

1993 • 88 citations

vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys

1995 • 86 citations

Pharmacology of Pentoxifylline A Hemorheologic Agent for the Treatment of Intermittent Claudication

1984 • 77 citations

Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents

1980 • 76 citations

Pentoxifylline for Intermittent Claudication

1994 • 73 citations

Cell cycle regulation andin vitrohybrid arrest analysis of the major human uracil-DNA glycosylase

1991 • 71 citations

In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa.

1988 • 70 citations

Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo.

1991 • 39 citations

Pentoxifylline for the Treatment of Infection with Human Immunodeficiency Virus

1994 • 37 citations

Structure of parental deoxyribonucleic acid of synchronized HeLa cells

1977 • 30 citations

Normal uracil-DNA glycosylase activity in Bloom's syndrome cells

1989 • 7 citations