Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard.

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1991 • 579 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.

1985 • 370 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.

1990 • 352 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks.

1988 • 307 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

Conservation of mitotic controls in fission and budding yeasts

1989 • 275 citations

Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.

1990 • 223 citations

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

1990 • 222 citations

Cloning and sequencing of the cyclin-related Cdc13 + gene and a cytological study of its role in fission yeast mitosis

1988 • 220 citations

Different drugs arrest cells at a number of distinct stages in G2

1975 • 201 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Molecular basis of control of mitotic cell division in eukaryotes

1974 • 195 citations

CYCLIN B EXPRESSION IN HELA CELLS DURING THE G2 BLOCK INDUCED BY IONIZING RADIATION

1991 • 165 citations

Cyclin B targets p34cdc2 for tyrosine phosphorylation.

1991 • 152 citations

Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage.

1989 • 134 citations

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.

1986 • 107 citations

Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.

1991 • 106 citations

G2 block induced by DNA crosslinking agents and its possible consequences

1988 • 96 citations

Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.

1991 • 85 citations

Molecules involved in proliferation of normal and cancer cells: presidential address.

1987 • 76 citations

The molecular basis of drug-induced G2 arrest in mammalian cells

1980 • 75 citations

Comparative Pharmacokinetics of DNA Lesion Formation and Removal Following Treatment of L1210 Cells with Nitrogen Mustards

1990 • 60 citations

Isolation and Characterization of Proteins Cross-linked to DNA by the Antitumor Agent Methylene Dimethanesulfonate and its Hydrolytic Product Formaldehyde

1989 • 40 citations

p34cdc2 is physically associated with and phosphorylated by a cdc2-specific tyrosine kinase.

1991 • 7 citations