A Designed Heterotrimeric Coiled Coil

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Analytical ultracentrifugation in biochemistry and polymer science

1995 • 1,970 citations

The packing of α-helices: simple coiled-coils

1953 • 1,549 citations

A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants

1993 • 1,456 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques

1981 • 845 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Protein Design by Binary Patterning of Polar and Nonpolar Amino Acids

1993 • 737 citations

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

1990 • 710 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils.

1984 • 559 citations

Characterization of a Helical Protein Designed from First Principles

1988 • 533 citations

Crystal structure of an isoleucine-zipper trimer

1994 • 467 citations

Peptide ‘Velcro’: Design of a heterodimeric coiled coil

1993 • 437 citations

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1992 • 422 citations

De Novo Design, Expression, and Characterization of Felix: a Four-Helix Bundle Protein of Native-Like Sequence

1990 • 392 citations

Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions

1990 • 379 citations

Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design.

1993 • 335 citations

Crystal Structure of a Synthetic Triple-Stranded α-Helical Bundle

1993 • 281 citations

Metal Ion-Dependent Modulation of the Dynamics of a Designed Protein

1993 • 252 citations

Effect of Chain Length on the Formation and Stability of Synthetic .alpha.-Helical Coiled Coils

1994 • 230 citations

Formation of a bispecific antibody by the use of leucine zippers.

1992 • 219 citations

The Role of Interhelical Ionic Interactions in Controlling Protein Folding and Stability

1994 • 189 citations

Synthetic model for two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin.

1981 • 179 citations

Packing and hydrophobicity effects on protein folding and stability: Effects of β‐branched amino acids, valine and isoleucine, on the formation and stability of two‐stranded α‐helical coiled coils/leucine zippers

1993 • 173 citations

Measurement of Interhelical Electrostatic Interactions in the GCN4 Leucine Zipper

1995 • 157 citations

Betadoublet: de novo design, synthesis, and characterization of a beta-sandwich protein.

1994 • 144 citations

Tetravalent Miniantibodies with High Avidity Assembling inEscherichia colo

1995 • 142 citations

Subdomain Folding of the Coiled Coil Leucine Zipper from the bZIP Transcriptional Activator GCN4

1994 • 112 citations

Ionic Interactions in the Coiled-coil Domain of Laminin Determine the Specificity of Chain Assembly

1993 • 102 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

Construction, purification, and characterization of a hybrid protein comprising the DNA binding domain of the LexA repressor and the Jun leucine zipper: a circular dichroism and mutagenesis study

1991 • 58 citations

Engineering the quaternary structure of an exported protein with a leucine zipper

1991 • 40 citations

Characteristics of a de novo designed protein

1994 • 30 citations

A sequential polyheptapeptide as a model for the double-stranded α-helical coiled-coil structure of tropomyosin

1976 • 10 citations

The solution synthesis of sequential polypeptides as models for the double-stranded coiled-coil structure of tropomyosin

1977 • 5 citations