Toll-Like Receptors in Normal and Cystic Fibrosis Airway Epithelial Cells

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products

1999 • 939 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

2000 • 744 citations

Inflammatory cytokines in cystic fibrosis lungs.

1995 • 702 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

2001 • 693 citations

Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

2001 • 652 citations

Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells

2000 • 556 citations

Defective acidification of intracellular organelles in cystic fibrosis

1991 • 490 citations

Role of Flagella in Pathogenesis ofPseudomonas aeruginosaPulmonary Infection

1998 • 467 citations

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

2003 • 435 citations

Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8.

1995 • 435 citations

Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs

2003 • 398 citations

Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids.

1988 • 396 citations

TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells

2002 • 355 citations

Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways

2004 • 352 citations

Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells.

1993 • 348 citations

Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.

1998 • 310 citations

Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium

2002 • 306 citations

Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa.

1997 • 265 citations

Inflammation and Infection in Naive Human Cystic Fibrosis Airway Grafts

2000 • 232 citations

Response toNeisseria gonorrhoeaeby Cervicovaginal Epithelial Cells Occurs in the Absence of Toll-Like Receptor 4-Mediated Signaling

2002 • 232 citations

IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB

2001 • 211 citations

Interaction of Pseudomonas aeruginosa with epithelial cells: Identification of differentially regulated genes by expression microarray analysis of human cDNAs

2000 • 179 citations

Bacterial Fimbriae and Their Peptides Activate Human Gingival Epithelial Cells through Toll-Like Receptor 2

2001 • 178 citations

Proinflammatory cytokine responses toP. aeruginosainfection in human airway epithelial cell lines

2001 • 176 citations

Activation of NF-κB in airway epithelial cells is dependent on CFTR trafficking and Cl⁻ channel function

2001 • 175 citations

Cystic Fibrosis Pathogens Activate Ca2+-dependent Mitogen-activated Protein Kinase Signaling Pathways in Airway Epithelial Cells

2001 • 170 citations

Exaggerated Activation of Nuclear Factor- κ B and Altered I κ B- β Processing in Cystic Fibrosis Bronchial Epithelial Cells

2000 • 168 citations

Transcriptional Regulation of the HumanToll-Like Receptor 2Gene in Monocytes and Macrophages

2002 • 158 citations

Pseudomonas aeruginosa Induction of Apoptosis in Respiratory Epithelial Cells

2000 • 140 citations

ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor

2001 • 140 citations

Recognition of Bacterial Endotoxin in the Lungs

2000 • 123 citations

Overproduction of the CFTR R Domain Leads to Increased Levels of AsialoGM1 and Increased Pseudomonas aeruginosa Binding by Epithelial Cells

1998 • 98 citations

Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung

2001 • 85 citations

Primary inflammation in human cystic fibrosis small airways

2002 • 79 citations

Terminal sialylation is altered in airway cells with impaired CFTR-mediated chloride transport

2001 • 27 citations