Establishment of infection: lessons from a versatile opportunist

Common Virulence Factors for Bacterial Pathogenicity in Plants and Animals

1995 • 1,322 citations

Early Pulmonary Inflammation in Infants with Cystic Fibrosis

1995 • 1,187 citations

Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

1997 • 1,069 citations

The changing epidemiology of cystic fibrosis

1993 • 930 citations

Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis

1980 • 661 citations

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.

1994 • 525 citations

Mucoid conversion of Pseudomonas aeruginos by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung

1999 • 480 citations

Role of Flagella in Pathogenesis ofPseudomonas aeruginosaPulmonary Infection

1998 • 467 citations

Role of Mutant CFTR in Hypersusceptibility of Cystic Fibrosis Patients to Lung Infections

1996 • 428 citations

Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections

1999 • 401 citations

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.

1994 • 381 citations

Mucoid Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosis

1992 • 369 citations

Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury

1999 • 351 citations

Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung

1997 • 313 citations

Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects.

1997 • 293 citations

Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

1984 • 286 citations

The genesis of cystic fibrosis lung disease

1999 • 275 citations

Cloning of genes controlling alginate biosynthesis from a mucoid cystic fibrosis isolate of Pseudomonas aeruginosa

1984 • 259 citations

A new polysaccharide resembling alginic acid isolated from pseudomonads.

1966 • 255 citations

Altered respiratory epithelial cell cytokine production in cystic fibrosis☆☆☆★

1999 • 249 citations

A New Polysaccharide Resembling Alginic Acid Isolated from Pseudomonads

1966 • 233 citations

Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon

1997 • 221 citations

Relationship between cytotoxicity and corneal epithelial cell invasion by clinical isolates of Pseudomonas aeruginosa

1996 • 216 citations

Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation

1994 • 212 citations

Treatment of syphilis with penicillin.

1946 • 189 citations

Agricultural Plants and Soil as a Reservoir for Pseudomonas aeruginosa

1974 • 185 citations

Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response

1994 • 183 citations

Genetic analysis of the alginate biosynthetic gene cluster of Pseudomonas aeruginosa shows evidence of an operonic structure

1993 • 183 citations

Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT

1994 • 182 citations

Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections

1997 • 182 citations

Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro

1995 • 175 citations

Corneal Ulcers Associated With Contact Lens Wear

1984 • 164 citations

Alginate Synthesis in Mucoid Pseudomonas aeruginosa: a Chromosomal Locus Involved in Control

1980 • 160 citations

Pseudomonas aeruginosa : clinical manifestations of infection and current therapy

1979 • 159 citations

An atypical Pseudomonas aeruginosa associated with cystic fibrosis of the pancreas

1966 • 158 citations

Improved growth and clinical, nutritional, and respiratory changes in response to nutritional therapy in cystic fibrosis

1980 • 154 citations

Ubiquity of plasmids in coding for toluene and xylene metabolism in soil bacteria: evidence for the existence of new TOL plasmids

1976 • 149 citations

Life-Threatening Pseudomonas aeruginosa Infections in Patients with Human Immunodeficiency Virus Infection

1992 • 136 citations

Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus

1994 • 135 citations

Persistence of a Multidrug-Resistant Pseudomonas aeruginosa Clone in an Intensive Care Burn Unit

1998 • 134 citations

Pili and lipopolysaccharide of Pseudomonas aeruginosa bind to the glycolipid asialo GM1

1994 • 130 citations

Pili Binding to Asialo-GM1 on Epithelial Cells Can Mediate Cytotoxicity or Bacterial Internalization by Pseudomonas aeruginosa

1999 • 129 citations

Mucoid Pseudomonas aeruginosa growing in a biofilm in vitro are killed by opsonic antibodies to the mucoid exopolysaccharide capsule but not by antibodies produced during chronic lung infection in cystic fibrosis patients.

1995 • 127 citations

Increased DNA levels in bronchoalveolar lavage fluid obtained from infants with cystic fibrosis.

1996 • 126 citations

Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection

1979 • 122 citations

In Vitro Cellular Toxicity Predicts Pseudomonas aeruginosa Virulence in Lung Infections

1998 • 120 citations

Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.

1996 • 119 citations

A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species

1993 • 117 citations

Extended contact lens wear enhances Pseudomonas aeruginosa adherence to human corneal epithelium.

1992 • 116 citations

Phosphorylation-Independent Activity of the Response Regulators AlgB and AlgR in Promoting Alginate Biosynthesis in Mucoid Pseudomonas aeruginosa

1998 • 115 citations

BACTERIAL PRECIPITINS 1N SERUM OF PATIENTS WITH CYSTIC FIBROSIS

1968 • 100 citations

Pseudomonas aeruginosa protease IV produces corneal damage and contributes to bacterial virulence.

1998 • 93 citations

Corneal Ulcers Associated with Extended-Wear Soft Contact Lenses

1984 • 92 citations

DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats

1990 • 92 citations

Pseudomonas infections in patients with AIDS and AIDS‐related complex

1992 • 86 citations

Cystic Fibrosis Transmembrane Conductance Regulator-Mediated Corneal Epithelial Cell Ingestion of Pseudomonas aeruginosa Is a Key Component in the Pathogenesis of Experimental Murine Keratitis

1999 • 80 citations

Contribution of the Regulatory Gene lasR to the Pathogenesis of Pseudomonas aeruginosa Infection of Burned Mice

1999 • 80 citations

Role of Pili in the Pathogenesis of Pseudomonas aeruginosa Burn Infection

1988 • 74 citations

Protease-deficient Mutants of Pseudomonas aeruginosa: Pleiotropic Changes in Activity of Other Extracellular Enzymes

1977 • 69 citations

Degradation of basement membranes by Pseudomonas aeruginosa elastase

1989 • 69 citations

Differences in adhesion of Pseudomonas aeruginosa to mucin glycopeptides from sputa of patients with cystic fibrosis and chronic bronchitis

1989 • 68 citations

Effect of anion transport inhibition on mucus secretion by airway submucosal glands

1997 • 68 citations

Rabbit corneal damage produced by Pseudomonas aeruginosa infection

1975 • 67 citations

How Mutant CFTR May Contribute to Pseudomonas aeruginosa Infection in Cystic Fibrosis

1996 • 66 citations

In vitro phosphorylation of AlgR, a regulator of mucoidy in Pseudomonas aeruginosa, by a histidine protein kinase and effects of small phospho‐donor molecules

1992 • 65 citations

Identification of the algZ gene upstream of the response regulator algR and its participation in control of alginate production in Pseudomonas aeruginosa

1997 • 64 citations

Corneal Rings With Gram-Negative Bacteria

1977 • 64 citations

Role of energy metabolism in conversion of nonmucoid Pseudomonas aeruginosa to the mucoid phenotype

1992 • 60 citations

Secretory IgA inhibits Pseudomonas aeruginosa binding to cornea and protects against keratitis.

1997 • 60 citations

Identification of a new phospholipase C activity by analysis of an insertional mutation in the hemolytic phospholipase C structural gene of Pseudomonas aeruginosa

1987 • 59 citations

Pseudomonas deficient in protease IV has significantly reduced corneal virulence.

1997 • 59 citations

Systematic review of antistaphylococcal antibiotic therapy in cystic fibrosis

1999 • 55 citations

Experimental bacterial keratitis in neutropenic guinea pigs: polymorphonuclear leukocytes in corneal host defense

1979 • 54 citations

Contribution of Exoenzyme S to the Virulence of Pseudomonas aeruginosa1

2015 • 54 citations

Evidence for asialo GM1 as a corneal glycolipid receptor for Pseudomonas aeruginosa adhesion

1993 • 53 citations

Phenotypic differences among clinically isolated mucoid Pseudomonas aeruginosa strains

1982 • 51 citations

Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection

1995 • 50 citations

Pathogenesis of corneal damage from pseudomonas exotoxin A.

1977 • 50 citations

Cornea and Sclera

1971 • 50 citations

Identification of the Histidine Protein Kinase KinB inPseudomonas aeruginosa and Its Phosphorylation of the Alginate Regulator AlgB

1997 • 49 citations

Influence of Malnutrition on the Concentration of IgA, Lysozyme, Amylase, and Aminopeptidase in Children's Tears

1978 • 48 citations

Pseudomonas eye infections in cyclophosphamide-treated mice.

1977 • 44 citations

Surface expression of ferripyochelin-binding protein is required for virulence of Pseudomonas aeruginosa

1987 • 42 citations

Cornea and Sclera

1972 • 41 citations

Efficacy of locally delivered polyclonal immunoglobulin against Pseudomonas aeruginosa infection in a murine burn wound model

1999 • 36 citations

Failure of Local Immunity

1985 • 35 citations

Endogenous and exogenous infection with Pseudomonas aeruginosa in a burns unit.

1981 • 33 citations

Selection of nonmucoid derivatives of mucoid Pseudomonas aeruginosa is strongly influenced by the level of iron in the culture medium

1982 • 30 citations

RODENT ZOONOSES IN NORTH QUEENSLAND

1978 • 29 citations

Experimental Pseudomonas keratitis in the rabbit: bacteriologic, clinical, and microscopic observations.

1981 • 29 citations

Infection control in a third world burn facility

1990 • 27 citations

Corneal collagenolytic activity in rabbit polymorphonuclear leukocytes

1976 • 25 citations

Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysis

1984 • 24 citations

The Effect of Endogenous Skin Bacteria on Burn Wound Infection

1989 • 22 citations

Cloning and expression of a gene segment encoding the enzymatic moiety of Pseudomonas aeruginosa exotoxin A

1984 • 21 citations

Two Neutropenic Patients with Multiple ResistantPseudomonas AeruginosaSepticaemia Treated with Ciprofloxacin

1987 • 21 citations

Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase

1991 • 20 citations

Detection of mucus glycoconjugates in human conjunctiva by using the lectin‐colloidal gold technique in TEM

1987 • 18 citations

The ductular cell in pancreatic cystic fibrosis

1965 • 16 citations

Pseudomonas aeruginosa infection of the cornea and asialo GM1

1995 • 15 citations

Further studies on the pathogenesis of fibrocystic disease of the pancreas.

1951 • 14 citations

Inhibition of Yeast Phagocytosis in Macrophage Cultures Treated With Slime Polysaccharide Purified From Pseudomonas aeruginosa

1984 • 7 citations

Fc and complement receptor integrity of polymorphonuclear (PMN) cells following thermal injury

1984 • 5 citations

Deleted Work

1955 • 0 citations